Epigenetic reprogramming in multiple myeloma—Challenges and opportunities
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar+2 more
wiley +1 more source
Management of multiple primary prostate malignant tumors: case report of synchronous prostatic adenocarcinoma and lymphoma. [PDF]
Zhuang W+5 more
europepmc +1 more source
CD86, the double agent: Significance of CD86 expression in B‐cell malignancies
Abstract Bypassing the anti‐tumor functions of the immune system is one of the keys to tumor survival. Tumors, especially hematological tumors, produce or express factors that retune T and B cells to inhibit the immune response. Coreceptors CD28 and CTLA‐4, and their ligands, CD80 and CD86, are involved in the immunological synapse and play an ...
Gábor Barna+4 more
wiley +1 more source
A Rare Case of T-Large Granular Lymphocytic (T-LGL) Leukemia in a Patient With Rheumatoid Arthritis With Neutropenia and Low LGL Level. [PDF]
Daniyal M+3 more
europepmc +1 more source
What's New? Current knowledge of the genetic architecture underlying the development of renal cell carcinoma‐related multiple primary tumours is limited. The authors comprehensively analysed the results of exome/genome sequencing cohorts including 534 patients to better define genotype–phenotype correlations.
Huairen Zhang+6 more
wiley +1 more source
V-H gene usage differs in germline and mutated B-cell chronic lymphocytic leukemia [PDF]
Amlot, P+8 more
core
Expression of ADAM10 and CD58 in Acute and Chronic Lymphocytic Leukemia: Influence of Disease Stage and Chemotherapy. [PDF]
Kadhim AH, Mohsin MI.
europepmc +1 more source
Body height and the excess cancer risk in men
What's New? In cancers that affect both sexes, men usually have a higher risk than women. While this is often attributed to behavioral factors, such as exposure to environmental carcinogens, there may be an intrinsic biological mechanism involved. Tall stature has been associated with increased cancer risk.
Cecilia Radkiewicz+6 more
wiley +1 more source
Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL [PDF]
Adrian C. Newland+61 more
core +1 more source
Toward immunoprofiling in MDS: A computational study of the bone marrow immune microenvironment
Cytometry Part B: Clinical Cytometry, EarlyView.
Margot F. van Spronsen+6 more
wiley +1 more source