Results 161 to 170 of about 102,788 (290)

Epigenetic reprogramming in multiple myeloma—Challenges and opportunities

open access: yesInternational Journal of Cancer, EarlyView.
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar   +2 more
wiley   +1 more source

CD86, the double agent: Significance of CD86 expression in B‐cell malignancies

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Bypassing the anti‐tumor functions of the immune system is one of the keys to tumor survival. Tumors, especially hematological tumors, produce or express factors that retune T and B cells to inhibit the immune response. Coreceptors CD28 and CTLA‐4, and their ligands, CD80 and CD86, are involved in the immunological synapse and play an ...
Gábor Barna   +4 more
wiley   +1 more source

Clinical and genetic features of multiple primary tumours cohorts with a renal cell carcinoma: Implications for molecular genetic investigations

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Current knowledge of the genetic architecture underlying the development of renal cell carcinoma‐related multiple primary tumours is limited. The authors comprehensively analysed the results of exome/genome sequencing cohorts including 534 patients to better define genotype–phenotype correlations.
Huairen Zhang   +6 more
wiley   +1 more source

V-H gene usage differs in germline and mutated B-cell chronic lymphocytic leukemia [PDF]

open access: yes, 2003
Amlot, P   +8 more
core  

Body height and the excess cancer risk in men

open access: yesInternational Journal of Cancer, EarlyView.
What's New? In cancers that affect both sexes, men usually have a higher risk than women. While this is often attributed to behavioral factors, such as exposure to environmental carcinogens, there may be an intrinsic biological mechanism involved. Tall stature has been associated with increased cancer risk.
Cecilia Radkiewicz   +6 more
wiley   +1 more source

Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL [PDF]

open access: yes, 2008
Adrian C. Newland   +61 more
core   +1 more source

Toward immunoprofiling in MDS: A computational study of the bone marrow immune microenvironment

open access: yes
Cytometry Part B: Clinical Cytometry, EarlyView.
Margot F. van Spronsen   +6 more
wiley   +1 more source

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