Results 261 to 270 of about 115,048 (305)

Stereotyped B-cell receptors in chronic lymphocytic leukemia

Leukemia & Lymphoma, 2014
Over the last decade, immunogenetic analysis of B-cell receptor immunoglobulins (BcR IGs) has proved to be a particularly fruitful field in chronic lymphocytic leukemia (CLL), not only for understanding disease pathogenesis but also for discriminating clinical subgroups with markedly distinct course and outcome.
Andreas, Agathangelidis, Anna, Vardi, Panagiotis, Baliakas, Kostas, Stamatopoulos   +3 more
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Genetic Features of B‐Cell Chronic Lymphocytic Leukemia

Reviews in Clinical and Experimental Hematology, 2000
The genetic features of B‐cell chronic lymphocytic leukemia CLL) are currently being reassessed by molecular cytogenetic techniques such as fluorescence in situ hybridization FISH). Conventional cytogenetic studies by chromosome banding are difficult in CLL mainly because of the low in vitro mitotic activity of the tumor cells, which leads to poor ...
S, Stilgenbauer, P, Lichter, H, Döhner
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Myelomonocytic antigens in B-cell chronic lymphocytic leukemia

Leukemia Research, 1995
The clinical significance of myelomonocytic (MyMo) antigens in B-cell chronic lymphocytic leukemia (B-CLL) is unclear. We have analyzed the expression of MyMo antigens (CD13, CD14 (LeuM3, My4, Mo2), CD15, CD11b, CD11c, CD33 and CD68) on B-lymphocytes (CD19+) in 105 B-CLL patients and in 35 controls.
D, Tàssies, E, Montserrat, J C, Reverter, N, Villamor, M, Rovira, C, Rozman   +5 more
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p53 Mutations in B-Cell Chronic Lymphocytic Leukemia

1992
The p53 gene is a nuclear phosphoprotein that can function as a tumor suppressor gene (Michalovitz et al. 1991). Frequent mutations of the p53 gene have been detected in several types of solid tumors including breast (Mackay et al. 1988), colon (Vogelstein et al. 1989), lung (Yokota et al. 1987), liver carcinoma (Hsu et al. 1991), astrocytoma (Fults et
S, el Rouby, W, Bayona, S M, Pisharody, E W, Newcomb   +3 more
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B-cell receptor signaling in chronic lymphocytic leukemia

Blood, 2011
AbstractThe B-cell receptor (BCR) is a key survival molecule for normal B cells and for most B-cell malignancies. Recombinatorial and mutational patterns in the clonal immunoglobulin (Ig) of chronic lymphocytic leukemia (CLL) have revealed 2 major IgMD-expressing subsets and an isotype-switched variant, each developing from distinct B-cell populations.
Stevenson, FK, Krysov, S, Davies, AJ, Steele, AJ, Packham, G   +4 more
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Richter syndrome in B‐cell chronic lymphocytic leukemia

Pathology International, 2003
Richter syndrome (RS) is well known as a secondary high‐grade lymphoma, mostly diffuse large B‐cell lymphoma (DLBCL) developed in patients with B‐cell chronic lymphocytic leukemia (B‐CLL). In this review, we describe clinicopathological, histological, immunophenotypical and genetic findings of RS.
Naoya, Nakamura, Masafumi, Abe
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Targeting B-cell anergy in chronic lymphocytic leukemia

Blood, 2013
Key Points A sizable fraction of CLL patients is characterized by the expansion of clonal B cells with anergic features. The constitutive biochemical signature of B-cell anergy can be efficiently targeted in CLL for therapeutic purposes.
Apollonio B, Scielzo C, Bertilaccio MT, Ten Hacken E, Scarfò L, Ranghetti P, Stevenson F, Packham G, GHIA , PAOLO PROSPERO, Muzio M, CALIGARIS CAPPIO , FEDERICO   +10 more
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11q13 Rearrangement in B Cell Chronic Lymphocytic Leukemia

Leukemia & Lymphoma, 1997
Translocation t(11;14)(q13;q32) and/or 11q13 rearrangements have been reported in various B cell immunoproliferative disorders. They appear to be frequent in mantle cell zone lymphoma (MZL) and rare in B-cell chronic lymphocytic leukemia (B-CLL). Discrimination between MZL and B-CLL is sometimes uncertain on the basis of morphology and immunophenotype.
F, Brizard, B, Dreyfus, F, Guilhot, J, Tanzer, A, Brizard   +4 more
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T-lymphocyte function in B-cell chronic lymphocytic leukemia

Clinical Immunology and Immunopathology, 1980
Summary. B‐enriched lymphocyte populations from patients with chronic lymphocytic leukaemia (CLL) were compared to B‐enriched lymphocyte populations from normal age‐matched controls for their ability to stimulate a proliferative response and to generate cytotoxic cells in allogeneic mixed lymphocyte cultures (MLC).
J A, Wolos, F R, Davey
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Antigen Receptor Function in Chronic Lymphocytic Leukemia B Cells

Leukemia & Lymphoma, 1996
Functional studies revealed that two groups of B chronic lymphocytic leukemia (B-CLL) can be distinguished based on their capacity to mount a proliferative response following B-cell antigen receptor (BCR) cross-linking. The molecular basis for the functional distinction between these B-CLL groups most probably resides within or proximal to the BCR ...
Lankester, A. C., Schijndel, G. M., Pakker, N. G., van Oers, R. H., van Lier, R. A.   +4 more
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