Results 261 to 270 of about 115,960 (309)
Some of the next articles are maybe not open access.
The normal counterpart to the chronic lymphocytic leukemia B cell
Best Practice & Research Clinical Haematology, 2007Chronic lymphocytic leukemia (CLL) is characterized by the monoclonal expansion of small mature-looking B cells that accumulate in the blood, marrow, and lymphoid organs, and have a remarkable phenotypic homogeneity. By definition, CLL cells co-express CD5 and CD23 with faint to undetectable amounts of monoclonal surface immunoglobulins (sIg).
Caligaris Cappio F +1 more
openaire +2 more sources
Alemtuzumab for B-cell chronic lymphocytic leukemia
Expert Review of Anticancer Therapy, 2008Alemtuzumab (Campath, MabCampath) is a humanized therapeutic monoclonal antibody (mAb) that recognizes the CD52 antigen expressed on normal and neoplastic lymphoid cells. This mAb is active in previously treated patients with B-cell chronic lymphocytic leukemia (B-CLL) refractory to alkylating agents and purine nucleoside analogs.
openaire +2 more sources
Angiogenesis is increased in B-cell chronic lymphocytic leukemia
Blood, 2001Aguayo and colleagues recently reported elevated levels of vascular endothelial growth factor (VEGF) in the cells of B-cell chronic lymphocytic leukemia (CLL).[1][1] When discussing the possible significance of the elevated VEGF levels in CLL, the authors cite their prior abstract in which ...
LoAnn Peterson, Ameet R. Kini, Neil Kay
openaire +2 more sources
Genetic Features of B‐Cell Chronic Lymphocytic Leukemia
Reviews in Clinical and Experimental Hematology, 2000The genetic features of B‐cell chronic lymphocytic leukemia CLL) are currently being reassessed by molecular cytogenetic techniques such as fluorescence in situ hybridization FISH). Conventional cytogenetic studies by chromosome banding are difficult in CLL mainly because of the low in vitro mitotic activity of the tumor cells, which leads to poor ...
S, Stilgenbauer, P, Lichter, H, Döhner
openaire +2 more sources
Stereotyped B-cell receptors in chronic lymphocytic leukemia
Leukemia & Lymphoma, 2014Over the last decade, immunogenetic analysis of B-cell receptor immunoglobulins (BcR IGs) has proved to be a particularly fruitful field in chronic lymphocytic leukemia (CLL), not only for understanding disease pathogenesis but also for discriminating clinical subgroups with markedly distinct course and outcome.
Andreas, Agathangelidis +3 more
openaire +2 more sources
Targeting B Cell Signaling in Chronic Lymphocytic Leukemia
Current Oncology Reports, 2017In recent years, a revolution in the management of chronic lymphocytic leukemia (CLL) has centered on the targeting of the B cell receptor (BCR) signaling pathway. Our improved understanding of the biology of cell signaling in CLL and the development of oral kinase inhibitors directed at the BCR pathway has led to the approval of two new agents and has
Jon E, Arnason, Jennifer R, Brown
openaire +2 more sources
B-cell receptor signaling in chronic lymphocytic leukemia
Blood, 2011AbstractThe B-cell receptor (BCR) is a key survival molecule for normal B cells and for most B-cell malignancies. Recombinatorial and mutational patterns in the clonal immunoglobulin (Ig) of chronic lymphocytic leukemia (CLL) have revealed 2 major IgMD-expressing subsets and an isotype-switched variant, each developing from distinct B-cell populations.
Stevenson, FK +4 more
openaire +3 more sources
The cellular biology of B-cell chronic lymphocytic leukemia
Critical Reviews in Oncology/Hematology, 1998In conclusion, B-CLL cells through their immunophenotype have the functional potential required to interact with cells in what has been called the immunological synapse, i.e. the cognate interactions between T-cells, antigen-presenting cells and B-cells during immunopoiesis.
openaire +2 more sources
Trisomy 8 in B-cell chronic lymphocytic leukemia
Cancer Genetics and Cytogenetics, 2008Association between trisomy 8 and myeloid disorders/malignancies has been well documented. We report on two patients with a known history of B-cell chronic lymphocytic leukemia (B-CLL) with bone marrow involvement. In addition to the classic B-CLL cytogenetic abnormalities in one of the patients, both showed a trisomy 8 clone in their bone marrow ...
Olga, Pozdnyakova +4 more
openaire +2 more sources
Assessment of a B-cell function in chronic lymphocytic leukemia
Clinical Immunology and Immunopathology, 1976Abstract Chronic lymphocytic leukemia (CLL) patients were tested for the numbers of T cells, B cells, and cells secreting immunoglobin (Ig) by recently developed methods with antibody coated erythrocytes. Five of seven patients had higher percentages (72–90%) of B cells and lower percentages (4–17%) of T cells than normal controls.
A J, Strelkauskas +3 more
openaire +2 more sources