Results 271 to 280 of about 115,960 (309)

p53 Mutations in B-Cell Chronic Lymphocytic Leukemia

1992
The p53 gene is a nuclear phosphoprotein that can function as a tumor suppressor gene (Michalovitz et al. 1991). Frequent mutations of the p53 gene have been detected in several types of solid tumors including breast (Mackay et al. 1988), colon (Vogelstein et al. 1989), lung (Yokota et al. 1987), liver carcinoma (Hsu et al. 1991), astrocytoma (Fults et
S, el Rouby, W, Bayona, S M, Pisharody, E W, Newcomb   +3 more
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Myelomonocytic antigens in B-cell chronic lymphocytic leukemia

Leukemia Research, 1995
The clinical significance of myelomonocytic (MyMo) antigens in B-cell chronic lymphocytic leukemia (B-CLL) is unclear. We have analyzed the expression of MyMo antigens (CD13, CD14 (LeuM3, My4, Mo2), CD15, CD11b, CD11c, CD33 and CD68) on B-lymphocytes (CD19+) in 105 B-CLL patients and in 35 controls.
D, Tàssies, E, Montserrat, J C, Reverter, N, Villamor, M, Rovira, C, Rozman   +5 more
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The neurologic complications of B-cell chronic lymphocytic leukemia

Neurology, 1997
We performed a retrospective study to characterize the type, frequency, and timing of neurologic complications in patients with B-cell chronic lymphocytic leukemia (B-CLL). We reviewed 962 total charts with a median follow-up time of 57.5 months. There were 109 cases (11.3%) of neurologic complications, including 69 cases (7.2%) of herpes zoster ...
J H, Bower, J E, Hammack, S K, McDonnell, A, Tefferi   +3 more
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Richter syndrome in B‐cell chronic lymphocytic leukemia

Pathology International, 2003
Richter syndrome (RS) is well known as a secondary high‐grade lymphoma, mostly diffuse large B‐cell lymphoma (DLBCL) developed in patients with B‐cell chronic lymphocytic leukemia (B‐CLL). In this review, we describe clinicopathological, histological, immunophenotypical and genetic findings of RS.
Naoya, Nakamura, Masafumi, Abe
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11q13 Rearrangement in B Cell Chronic Lymphocytic Leukemia

Leukemia & Lymphoma, 1997
Translocation t(11;14)(q13;q32) and/or 11q13 rearrangements have been reported in various B cell immunoproliferative disorders. They appear to be frequent in mantle cell zone lymphoma (MZL) and rare in B-cell chronic lymphocytic leukemia (B-CLL). Discrimination between MZL and B-CLL is sometimes uncertain on the basis of morphology and immunophenotype.
F, Brizard, B, Dreyfus, F, Guilhot, J, Tanzer, A, Brizard   +4 more
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T-lymphocyte function in B-cell chronic lymphocytic leukemia

Clinical Immunology and Immunopathology, 1980
Summary. B‐enriched lymphocyte populations from patients with chronic lymphocytic leukaemia (CLL) were compared to B‐enriched lymphocyte populations from normal age‐matched controls for their ability to stimulate a proliferative response and to generate cytotoxic cells in allogeneic mixed lymphocyte cultures (MLC).
J A, Wolos, F R, Davey
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B cell chronic lymphocytic leukemia with meningeal infiltration by T lymphocytes

European Journal of Internal Medicine, 2003
Chronic lymphocytic leukemia (CLL) is a generalized malignancy of the lymphoid tissue characterized by an accumulation of monoclonal lymphocytes, usually of the B cell type. Involvement of the central nervous system is a rare complication, usually seen in T cell leukemias.
Anna, Remková, Tatiana, Bezayová, Milan, Vyskocil   +2 more
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Chromosome studies in stimulated lymphocytes of B‐Cell chronic lymphocytic leukemias

Hematological Oncology, 1983
AbstractUsing a sister chromatid differentiation technique, cell cycle study of stimulated lymphocytes of B‐Cell chronic lymphocytic leukemia (B‐CLL) revealed their cell cycle progression to be similar to that of normal lymphocytes stimulated by T‐cell and various polyclonal B‐cell activators (PBA).
N, Sadamori, T, Han, J, Minowada, E, Cohen, A A, Sandberg   +4 more
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Modulation of apoptosis by cytokines in B‐cell chronic lymphocytic leukemia

Cytometry, 1999
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the slow and progressive accumulation of monoclonal apparently mature, CD5(+) B lymphocytes. The majority of circulating cells appear to be nondividing, and it has been suggested that a prolonged life span is mainly responsible for the accumulation of the leukemic cells.
R, Castejón, J A, Vargas, Y, Romero, M, Briz, R M, Muñoz, A, Durántez   +5 more
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ATM mutations in B-cell chronic lymphocytic leukemia.

Cancer research, 1999
Mutations in the ATM gene located on the long arm of chromosome 11 at 11q22-23 cause ataxia-telangiectasia, an autosomal recessive disorder that is associated with increased incidence of malignancy and, particularly, lymphoid tumors. A role for ATM in the development of sporadic T-cell chronic leukemias is supported by the finding of loss of ...
F. Bullrich, RASIO, DEBORA, S. Kitada, P. Starostik, T. Kipps, M. Keating, M. Albitar, J. C. Reed, Croce, C. M. Cancer Res Jan   +9 more
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