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ATM mutations in B-cell chronic lymphocytic leukemia.
Cancer research, 1999Mutations in the ATM gene located on the long arm of chromosome 11 at 11q22-23 cause ataxia-telangiectasia, an autosomal recessive disorder that is associated with increased incidence of malignancy and, particularly, lymphoid tumors. A role for ATM in the development of sporadic T-cell chronic leukemias is supported by the finding of loss of ...
F. Bullrich +9 more
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B cell chronic lymphocytic leukemia with meningeal infiltration by T lymphocytes
European Journal of Internal Medicine, 2003Chronic lymphocytic leukemia (CLL) is a generalized malignancy of the lymphoid tissue characterized by an accumulation of monoclonal lymphocytes, usually of the B cell type. Involvement of the central nervous system is a rare complication, usually seen in T cell leukemias.
Anna, Remková +2 more
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Modulation of apoptosis by cytokines in B‐cell chronic lymphocytic leukemia
Cytometry, 1999B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the slow and progressive accumulation of monoclonal apparently mature, CD5(+) B lymphocytes. The majority of circulating cells appear to be nondividing, and it has been suggested that a prolonged life span is mainly responsible for the accumulation of the leukemic cells.
R, Castejón +5 more
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p53 Mutations in B-Cell Chronic Lymphocytic Leukemia
1992The p53 gene is a nuclear phosphoprotein that can function as a tumor suppressor gene (Michalovitz et al. 1991). Frequent mutations of the p53 gene have been detected in several types of solid tumors including breast (Mackay et al. 1988), colon (Vogelstein et al. 1989), lung (Yokota et al. 1987), liver carcinoma (Hsu et al. 1991), astrocytoma (Fults et
S, el Rouby +3 more
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Antigen Receptor Function in Chronic Lymphocytic Leukemia B Cells
Leukemia & Lymphoma, 1996Functional studies revealed that two groups of B chronic lymphocytic leukemia (B-CLL) can be distinguished based on their capacity to mount a proliferative response following B-cell antigen receptor (BCR) cross-linking. The molecular basis for the functional distinction between these B-CLL groups most probably resides within or proximal to the BCR ...
Lankester, A. C. +4 more
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Ibrutinib in chronic lymphocytic leukemia and B cell malignancies
Leukemia & Lymphoma, 2013Recent clinical data suggest remarkable activity of ibrutinib, the first-in-class covalent inhibitor of Bruton's tyrosine kinase (BTK), in chronic lymphocytic leukemia (CLL), as well as excellent activity in other B cell malignancies, including in particular mantle cell lymphoma and Waldenstrom macroglobulinemia.
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E Rosette Formation in B Cell Chronic Lymphocytic Leukemia
Acta Haematologica, 2009We describe a patient with B cell chronic lymphocytic leukemia whose B lymphocytes showed the capacity to form rosettes with sheep red blood cells during prolymphocytoid transformation of the disease. In this case, rosette formation was found to be related to the presence of the classic E rosette receptor since the leukemic cells were recognized by the
MUSOLINO, Caterina +7 more
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The cellular biology of B-cell chronic lymphocytic leukemia
Critical Reviews in Oncology/Hematology, 1998In conclusion, B-CLL cells through their immunophenotype have the functional potential required to interact with cells in what has been called the immunological synapse, i.e. the cognate interactions between T-cells, antigen-presenting cells and B-cells during immunopoiesis.
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B Cell Chronic Lymphocytic Leukemia
Annals of the New York Academy of Sciences, 2003RAJENDRA N. DAMLE +9 more
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