Results 51 to 60 of about 162,094 (212)
A rare presentation of chronic myeloid leukemia blast crisis
Iraqi Journal of Hematology, 2020 Chronic myeloid leukemia (CML), as the name suggests, is a chronic disorder in which granulocytes undergo dysregulated production and uncontrolled proliferation. Majority of CML patients present during the chronic phase (CP) of the disease.
P S Shruthi +3 more
doaj +1 more source
Differential disease restriction of Moloney and Friend murine leukemia viruses by the mouse Rmcf gene is governed by the viral long terminal repeat. [PDF]
, 1991 Neonatal CxD2 (Rmcfr) and Balb/c (Rmcfs) mice inoculated with Moloney murine leukemia virus (M-MuLV) exhibited approximately equivalent time course and pathology for disease.
Brightman, BK, Fan, H, Li, QX, Trepp, DJ
core
CREB is a critical regulator of normal hematopoiesis and leukemogenesis [PDF]
, 2008 The cAMP-responsive element binding protein (CREB) is a 43-kDa nuclear transcription factor that regulates cell growth, memory, and glucose homeostasis. We showed previously that CREB is amplified in myeloid leukemia blasts and expressed at higher levels
Akashi +55 more
core +3 more sources
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Artery tertiary lymphoid organs control multi-layered territorialized atherosclerosis B cell responses in aged ApoE-/- mice [PDF]
, 2016 Objective: Explore aorta B cell immunity in aged ApoE-/- mice. Approach and Results: Transcript maps, FACS, immunofluorescence analyses, cell transfers, and Ig-ELISPOT assays showed multi-layered atherosclerosis B cell responses in artery tertiary ...
Andreas J.R. Habenicht +13 more
core +1 more source
Advanced Healthcare Materials, EarlyView.We present a strategy to enhance magnetic hyperthermia therapy by modulating nanoparticle–cell interactions. Antibody‐functionalized magnetic nanoparticles targeting the low‐internalizing CCR9 receptor enable spatially controlled membrane anchoring, reducing aggregation and maximizing heat generation under alternating magnetic fields.
David Egea‐Benavente +5 more
wiley +1 more source
Long-term cultures of murine fetal liver retain very early B lymphoid phenotype. [PDF]
, 1984 Long-term cultures of murine fetal liver have been successfully established using a modification of our in vitro bone marrow culture system (14, 15).
Denis, KA +3 more
core
Role of HOX Genes in Stem Cell Differentiation and Cancer. [PDF]
, 2018 HOX genes encode an evolutionarily conserved set of transcription factors that control how the phenotype of an organism becomes organized during development based on its genetic makeup.
Bhatlekar, Seema +2 more
core +2 more sources
Advanced Science, EarlyView.This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao +13 more
wiley +1 more source
Clinical characteristics and outcome of children with biphenotypic acute leukemia
Haematologica, 2009 Background Knowledge concerning the clinical and biological presentation, as well as the outcome of treatment, of biphenotypic acute leukemia in children is limited.Design and Methods This retrospective review analyzes the clinical features and outcome ...
Amal S. Al-Seraihy +6 more
doaj +1 more source