A dual origin for Bcr-Abl gene translocation/fusion as dynamics of synergism of the hematopoietic stem cell and hemangioblast in chronic myeloid leukemia [PDF]
, 2015 Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
core +1 more source
Extracellular vesicles in cancers: mechanisms, biomarkers, and therapeutic strategies
MedComm, Volume 5, Issue 12, December 2024.Extracellular vesicles (EVs) composed of proteins, nucleic acids, lipids, and metabolites are a notable mechanism of intercellular communication. This review will examine how biological components in EVs affect cancer growth and the tumor microenvironment's complex interactions.
Yuxi Ma +3 more
wiley +1 more source
Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogene[S]
Journal of Lipid Research, 2013 Sphingomyelin synthase (SMS) produces sphingomyelin while consuming ceramide (a negative regulator of cell proliferation) and forming diacylglycerol (DAG) (a mitogenic factor). Therefore, enhanced SMS activity could favor cell proliferation.
Tara Ann Burns +9 more
doaj
Detection of derivative 9 deletion by BCR-ABL fluorescence in-situ hybridization signal pattern to evaluate treatment response in CML patients [PDF]
Archive of Oncology, 2009 Background: To evaluate prognostic effect of submicroscopic deletions involving breakage and fusion points of the derivative chromosome 9 and 22 in chronic myeloid leukemia in untreated patients and their follow up samples to correlate with disease ...
Bakshi Sonal R. +8 more
doaj +1 more source
Study of the behaviour of proliferating cells in leukemia modelled by a system of delay differential equations [PDF]
arXiv, 2014 For the model of periodic chronic myelogenous leukemia considered by Pujo-Menjouet, Mackey et al., model consisting of two delay differential equations, the equation for the density of so-called "resting cells" was studied from numerical and qualitative point of view in several works.
arxiv
Dasatinib and azacitidine followed by haploidentical stem cell transplant for chronic myeloid leukemia with evolving myelodysplasia: A case report and review of treatment options. [PDF]
, 2017 BACKGROUND: CML presenting with a variant Philadelphia translocation, atypical BCR-ABL transcript, additional chromosomal aberrations, and evolving MDS is uncommon and therapeutically challenging.
Ottmann, Oliver
core +2 more sources
RNA modification in normal hematopoiesis and hematologic malignancies
MedComm, Volume 5, Issue 11, November 2024.N6‐methyladenosine (m6A) is the most abundant RNA modification in eukaryotic cells. Previous studies have shown that m6A plays a critical role under both normal physiological and pathological conditions. This review systematically reviews the latest research advancements on the roles and mechanisms of m6A regulatory factors in normal hematopoiesis and ...
Xi Chen +5 more
wiley +1 more source
Oscillations in a maturation model of blood cell production [PDF]
arXiv, 2004 In this paper we use a continuous model to describe the development of a single cell lineage following the committal of stem cells. Three separate controls are implemented in the model, namely the proliferative control of stem cells, the proliferative control of developing blast cells, and the peripheral control of stem cell committal by circulating ...
arxiv
Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells [PDF]
, 2011 Chronic myeloid leukaemia (CML) is maintained by a rare population of tyrosine kinase inhibitor (TKI)-insensitive malignant stem cells. Our long-term aim is to find a BcrAbl-independent drug that can be combined with a TKI to improve overall disease ...
A Quintas-Cardama +27 more
core +1 more source
International Journal of Biomedical Research, 2018 Breakpoint cluster region-abelson (BCR-ABL) leukemic fusion gene types in chronic myeloid leukemia (CML) correlate with the disease clinical course and outcome.
Abdalla Abdelrahman Ahmed Elnour +1 more
semanticscholar +1 more source