Results 71 to 80 of about 12,771 (176)

A Case of Hepatocellular Carcinoma after Treatment for Chronic Myeloid Leukemia in a Patient without Liver Disease

Case Reports in Oncology
Introduction: Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by the reciprocal translocation of chromosomes 9 and 22, which leads to a chimeric gene product known as BCR-ABL.
Darshankumar M. Raval, Ricardo J. Pagán, Shayan Butt, Libardo Rueda Prada   +3 more
doaj   +1 more source

The significance of major and stable molecular responses in chronic myeloid leukemia in the tyrosine kinase inhibitor era

Revista Brasileira de Hematologia e Hemoterapia, 2011
Tyrosine kinase inhibitors have changed the management and outcomes of chronic myeloid leukemia patients. Quantitative polymerase chain reaction is used to monitor molecular responses to tyrosine kinase inhibitors.
Ilana Zalcberg Renault, Vanesa Scholl, Rocio Hassan, Paola Capelleti, Marcos de Lima, Jorge Cortes   +5 more
doaj   +1 more source

The Anti‐Leukemic Potential of Curcumin in Chronic Myeloid Leukemia: A Systematic Review of In Vitro Studies

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
Curcumin suppresses chronic myeloid leukemia progression through multiple molecular pathways. It inhibits BCR‐ABL1, modulates miR‐21, PKCα, and PTEN, activates DR4/DR5, blocks G2/M cell cycle progression, and inhibits HDAC. These actions collectively promote apoptosis, enhance tumor suppressor expression, and reduce leukemic cell proliferation ...
Hossein Bahari, Zeinab Salim, Leila Kardanpour, Hosein Kouchaki, Fatemeh Shoja, Iman Rahnama, Arezoo Faridzadeh, Maryam Ranjbar Zahedani   +7 more
wiley   +1 more source

Serum concentrations of nitrite and malondialdehyde as markers of oxidative stress in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

Revista Brasileira de Hematologia e Hemoterapia, 2012
BACKGROUND: Chronic myeloid leukemia is a neoplasm characterized by clonal expansion of hematopoietic progenitor cells resulting from the (9:22)(q34,11) translocation.
Maria Juracy Petrola, Alana Joselina Montenegro de Castro, Maria Helena da Silva Pitombeira, Maritza Cavalcante Barbosa, Acy Telles de Souza Quixadá, Fernando Barroso Duarte, Romelia Pinheiro Gonçalves   +6 more
doaj   +1 more source

Successful Allogeneic Stem Cell Transplant for Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia After Pneumonectomy for Pulmonary Mucormycosis: A Case Report and Review of the Literature

eJHaem, Volume 6, Issue 4, August 2025.
ABSTRACT The incidence of relapsed Philadelphia chromosome‐negative acute lymphoblastic leukemia in adults is estimated to be 40%–50%. Allogeneic stem cell transplantation can improve survival in relapsed acute lymphoblastic leukemia; however, impaired pulmonary function is detrimental for surviving the transplantation process.
Alexander O'Hara, Sanja Zepcan, Stephanie Tsai, Imran Puthawala, Jorgena Kosti‐Schwartz   +4 more
wiley   +1 more source

CDK8/19 inhibition attenuates G1 arrest induced by BCR-ABL antagonists and accelerates death of chronic myelogenous leukemia cells

Cell Death Discovery
Imatinib mesylate (IM) and other BCR-ABL tyrosine kinase inhibitors (BCR-ABLi) are the mainstay of chronic myelogenous leukemia (CML) treatment. However, activation of circumventing signaling pathways and quiescence may limit BCR-ABLi efficacy.
Alvina I. Khamidullina, Margarita A. Yastrebova, Alexandra V. Bruter, Julia V. Nuzhina, Nadezhda E. Vorobyeva, Anastasia M. Khrustaleva, Ekaterina A. Varlamova, Alexander V. Tyakht, Iaroslav E. Abramenko, Ekaterina S. Ivanova, Maria A. Zamkova, Jing Li, Chang-Uk Lim, Mengqian Chen, Eugenia V. Broude, Igor B. Roninson, Alexander A. Shtil, Victor V. Tatarskiy   +17 more
doaj   +1 more source

Diversity of breakpoints of variant Philadelphia chromosomes in chronic myeloid leukemia in Brazilian patients

Revista Brasileira de Hematologia e Hemoterapia, 2015
Background: Chronic myeloid leukemia is a myeloproliferative disorder characterized by the Philadelphia chromosome or t(9;22)(q34.1;q11.2), resulting in the break-point cluster regionAbelson tyrosine kinase fusion gene, which encodes a constitutively ...
Maria de Lourdes Lopes Ferrari Chauffaille, Ana Carolina de Almeida Bandeira, Aline Schiavoni Guarnieri da Silva   +2 more
doaj   +1 more source

Pediatric chronic myeloid leukemia in myeloid blast crisis

Autopsy and Case Reports, 2023
Chronic myeloid leukemia (CML) accounts for 2-3% of childhood leukemias. About 5% of cases present in a blastic phase of CML which clinically and morphologically mimics more common acute leukemias of childhood.
Biswajit Dey, Anirban Dutta
doaj  

TREATMENT WITH IMATINIB MESILAT IN CHRONIC MYELOGENOUS LEUKEMIA – OUR EXPERIENCE

Zdravniški Vestnik, 2004
Background. Chronic myelogenous leukemia (CML) is a malignant clonal disorder of hematopoietic stem cell. In majority of patients we find reciprocal chromosomal translocation t (9.22) which result in fusion oncoprotein with tyrosine kinase activity.
Mateja Grat, Joško Vučkovič
doaj  

Progression significance for low‐level aberrant B‐lymphoblasts in chronic myeloid leukaemia patients

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
Haoren Wang, Huijun Wang, Yuanyuan Li, Bin Zheng, Qiuyun Fang, Yan Li, Yuntao Liu, Runxia Gu, Ying Wang, Yingchang Mi, Bingcheng Liu, Hui Wei, Jianxiang Wang   +12 more
wiley   +1 more source