Results 61 to 70 of about 166,676 (142)
Azacitidine as salvage therapy for acute myeloid leukemia in a severely ill patient
Hematology Reports, 2014 Acute myeloid leukemia (AML) is a hematological malignancy of myeloid progenitor cells that disrupt normal hematopoiesis. Current chemotherapy regimens result in complete remission in many cases; however, there exists no standard efficacious therapy for ...
Harry Ross Powers +4 more
doaj +1 more source
Haematologica, 2019 Normal hematopoiesis can be disrupted by the leukemic bone marrow microenvironment, which leads to cytopenia-associated symptoms including anemia, hemorrhage and infection.
Ai Gao +10 more
doaj +1 more source
Acute lymphoblastic leukemia may develop as a result of rapid transformation of a lymphoblast triggered by repeated bone-remodeling during bone-growth [PDF]
arXiv, 2018 Acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL) are two major forms of leukemia that arise from lymphoid cells (LCs). ALL occurs mostly in children and CLL occurs mainly in old people. However, the Philadelphia-chromosome-positive ALL (Ph+-ALL) and the Ph-like ALL occur in both children and adults.
arxiv
Haematologica, 2012 Background Protein phosphatase 2A is a novel potential therapeutic target in several types of chronic and acute leukemia, and its inhibition is a common event in acute myeloid leukemia.
Ion Cristóbal +6 more
doaj +1 more source
A mathematical model of clonal hematopoiesis explaining phase transitions in myeloid leukemia [PDF]
arXivThis study presents a mathematical model describing cloned hematopoiesis in chronic myeloid leukemia (CML) through a nonlinear system of differential equations. The primary objective is to understand the progression from normal hematopoiesis to the chronic and accelerated-acute phases in myeloid leukemia.
arxiv
The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia
Haematologica, 2018 Epigenetic alterations contribute to leukemogenesis in childhood acute myeloid leukemia and therefore are of interest for potential therapeutic strategies.
Yaser Heshmati +11 more
doaj +1 more source
Tumor Biology, 2019 Aurora kinases play critical roles in regulating several processes pivotal for mitosis. Radotinib, which is approved in South Korea as a second-line treatment for chronic myeloid leukemia, inhibits the tyrosine kinase BCR-ABL and platelet-derived growth ...
Sook-Kyoung Heo +10 more
doaj +1 more source
Identification and Counting White Blood Cells and Red Blood Cells using Image Processing Case Study of Leukemia [PDF]
arXiv, 2015 Leukemia is diagnosed with complete blood counts which is by calculating all blood cells and compare the number of white blood cells (White Blood Cells / WBC) and red blood cells (Red Blood Cells / RBC). Information obtained from a complete blood count, has become a cornerstone in the hematology laboratory for diagnostic purposes and monitoring of ...
arxiv
Haematologica, 2010 Background Residual chronic myeloid leukemia disease following imatinib treatment has been attributed to the presence of quiescent leukemic stem cells intrinsically resistant to imatinib.
Fabrizio Vianello +10 more
doaj +1 more source
Automated Immunophenotyping Assessment for Diagnosing Childhood Acute Leukemia using Set-Transformers [PDF]
arXivAcute Leukemia is the most common hematologic malignancy in children and adolescents. A key methodology in the diagnostic evaluation of this malignancy is immunophenotyping based on Multiparameter Flow Cytometry (FCM). However, this approach is manual, and thus time-consuming and subjective. To alleviate this situation, we propose in this paper the FCM-
arxiv