Results 71 to 80 of about 265,018 (314)
Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells [PDF]
, 2011 Chronic myeloid leukaemia (CML) is maintained by a rare population of tyrosine kinase inhibitor (TKI)-insensitive malignant stem cells. Our long-term aim is to find a BcrAbl-independent drug that can be combined with a TKI to improve overall disease ...E K Allan, Holyoake, T.L., Jorgensen, H.G., A R Craig, T L Holyoake, Allan, E.K., Craig, A.R., H G Jørgensen +7 morecore +1 more sourceDevelopment of hypogammaglobulinemia in patients treated with imatinib for chronic myeloid leukemia or gastrointestinal stromal tumor
Haematologica, 2008 Imatinib mesylate is a tyrosine kinase inhibitor used as first line treatment in chronic myeloid leukemia and gastrointestinal stromal tumorpatients. Although several in vitro and animal studies demonstrated that imatinib affects immune response, few ...Rita Santachiara, Rossana Maffei, Silvia Martinelli, Annalisa Arcari, Federico Piacentini, Elena Trabacchi, Pierluigi Alfieri, Angela Ferrari, Giovanna Leonardi, Gabriele Luppi, Giuseppe Longo, Daniele Vallisa, Roberto Marasca, Giuseppe Torelli +13 moredoaj +1 more sourceCancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer +7 morewiley +1 more sourceStudies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors [PDF]
, 2002 FLT3 mutations, either internal tandem duplications (ITDs) or aspartate residue 835 (D835) point mutations, are present in approximately one third of patients with acute myeloid leukemia (AML) and have been associated with an increased relapse rate.Kottaridis, P.D., Gale, R.E., Bowen, D.T., Langabeer, S.E., Frew, M.E., Linch, D.C. +5 morecore A certified plasmid reference material for the standardisation of BCR-ABL1 mRNA quantification by real time quantitative PCR [PDF]
, 2015 Serial quantification of BCR–ABL1 mRNA is an important therapeutic indicator in chronic myeloid leukaemia, but there is a substantial variation in results reported by different laboratories.Mitterbauer, G., Kim, D.-W., S McCarron, Polakova, K.M., Hall, V, Preudhomme, C., K M Polakova, Hall, V., Schimmel, Heinz G., Cross, N.CP., L Foroni, Gerrard, G., Waits, Paula S., Cross, N.C.P., Jansson, Mattias,, Polakova, Km, Ozbek, U (Ugur), E O Leibundgut, El Housni, Hakim, R Ganderton, E Gineikienė, G Martinelli, Kizilors, A., White, H., Corbisier, P., Hayette, S, Colomer, D., Ganderton, R., Mueller, M. C., Kim, D-W, Van der Velden, V. H. J., de Lange, T, P Waits, Wilson, G., Mitterbauer Hohendanner, G, Cross, Nicholas C P., J Nomdedéu, Nagar, M, Nagar, M., Merle, P. A., Clench, T, Müller, M.C., Hochhaus, A., Fletcher, L, Deprez, Ludovic, Milner, B., Jurcek, Tomas, Nymoen, D. A., Andrikovics, H., T Sacha, Touloumenidou, Tasoula, Cayuela, J-M, Boeckx, N., Merle, Pauline A., Lange, T, Emons, H, Wang, L., Wang, L, D-W Kim, T Jurcek, Touloumenidou, T, Trapmann, Stefanie, A Aggerholm, Gineikiene, Eglė, Barbany, G., McCarron, S., V Kairisto, Mazoua, S., Schimmel, H, Polakova, K M, S Hayette, White, H, Barbany, G, H White, C Preudhomme, Cayuela, Jm, G Romeo, R Talmaci, Lin, Feng, K Zoi, Aggerholm, A, Lion, T, Akiki, S., Jurcek, T., Kairisto, V, A Kizilors, IZZO, BARBARA, Aggerholm, A., Van der Velden, Vh, Mueller, MC, F Lin, Colomer, D, Leibundgut, E O, Hochhaus, A, J Farrugia, Müller, Mc, Milner, B, G Mitterbauer-Hohendanner, Trapmann, S., Leibundgut, Eo, U Ozbek, Waits, P., Daraio, Filomena, Farrugia, J., Nomdedéu, J, Kizilors, Aytug, Preudhomme, C, Wilson, Gillian A., Ozbek, U, Lange, Thoralf, H Andrikovics, Andrikovics, H, El Housni, H, Emons, Hendrik, Deprez, L., Kim, Dong-Wook, Lin, F., Wilkinson, E., S Chudleigh, Dulucq, S., Schimmel, H., Izzo, B., D Colomer, Hayette, S., D Wren, Corbisier, Philippe, P Johnels, Cross, Nc, M Nagar, Zoi, K, V H J Van der Velden, N Boeckx, Bench, Anthony J., Aggerholm, Anni, El Housni, H., Gineikienė, E, H El Housni, Catherwood, M., Kairisto, Veli, Nagar, Meital, Catherwood, Mark Alexander, Hall, Victoria J., Wang, Lihui, Pfeifer, H, R Zadro, Milner, Benedict J., Nymoen, Dag André, Zadro, Renata, Leibundgut, E. O., Kim, Dw, S Trapmann, Fletcher, L., Kairisto, V., Daraio, F, Romeo, Giuliana, K Raudsepp, Akiki, S, Lin, F, L Wang, M Catherwood, Van der Velden, V.H.J., Dulucq, S, Wilson, G, M Jansson, Hochhaus, Andreas, Merle, P A, Nickless, Guillermina, Pajič, T, van der Velden, Vincent, Jansson, M, T Clench, Bench, A, Nomdedéu, Josep, T Touloumenidou, Universitat Autònoma de Barcelona. Departament de Medicina, Müller, M C, Deprez, L, Romeo, G, Foroni, L, Raudsepp, K, Mazoua, Stéphane, Wren, Dörte, Hayette, Sandrine, A Hochhaus, Machová Polakova, Katerina Machová, Foroni, L., Mitterbauer-Hohendanner, G, S Mazoua, Catherwood, M, Cayuela, J.M., Ziermann, Janine, F Daraio, S Dulucq, Sacha, T, Chudleigh, Sandra, G Gerrard, Chudleigh, S, G Wilson, Gerrard, Gareth, Farrugia, J, B Milner, M C Müller, P A Merle, Wilkinson, E, L Fletcher, Emons, H., Polakova, K. M., V Hall, Van der Velden, V.HJ., Wren, D., Nickless, G, Pajič, T., Sacha, T., Cross, N C P, Merle, Pa, Pfeifer, Heike, Merle, P.A., Ziermann, J, Touloumenidou, T., Zoi, K., Cross, NCP, Lion, Thomas, Trapmann, S, Wren, D, El Akiki, Susanna, McCarron, S, H Pfeifer, Corbisier, P, Wilkinson, Elizabeth, Pfeifer, H., Jurcek, T, Johnels, P., Boeckx, Nancy, Gerrard, G, N C P Cross, Ziermann, J., Leibundgut, O., Zadro, R., Martinelli, G., Colomer, Dolors, Izzo, B, White, Helen E., Romeo, G., T Pajič, Farrugia, Joanna, H Emons, P Corbisier, A Bench, Lange, T., G Barbany, Foroni, Letizia, Ganderton, Rosalind H., Raudsepp, K., Mitterbauer-Hohendanner, G., J Ziermann, Martinelli, G, Waits, P, Clench, Tim, Ganderton, R, Daraio, F., Zadro, R, H Schimmel, Kim, D-W., Johnels, Petra, Fletcher, Linda, G Nickless, D A Nymoen, Chudleigh, S., Talmaci, R., Mazoua, S, Nymoen, Da, Oppliger Leibundgut, Elisabeth, T Lion, Bench, A., Dulucq, Stéphanie, Clench, T., Nickless, G., Gineikienė, E., L Deprez, E Wilkinson, Zoi, Katerina, Boeckx, N, Nymoen, D.A., Leibundgut, E.O., T Lange, Nymoen, D A, J-M Cayuela, Mueller, M.C., Johnels, P, Barbany-Bustinza, Gisela, Sacha, Tomasz, Jansson, M., Mitterbauer-Hohendanner, Gerlinde Juliane, Lion, T., Müller, Martin Christian, Van der Velden, VHJ, Cayuela, J-M., B Izzo, Kizilors, A, Kim, D.W., Van der Velden, V H J, Van der Velden54, V.H.J., Cayuela, Jean Michel, Ozbek, U., MARTINELLI, GIOVANNI, Andrikovics, Hajnalka, Talmaci, R, Nomdedéu, J., Cross, N. C. P., S Akiki, Preudhomme, Claude, Ozbek, Ugur, Pajič, Tadej, Wang, L (Liang), Van Der Velden, Vincent H. J., Jansson, Mattias, Deprez, Liesbet +316 morecore +1 more sourceBlocking the APRIL circuit enhances acute myeloid leukemia cell chemosensitivity
Haematologica, 2008 Resistance to chemotherapy-induced cell death represents a major obstacle in the treatment of acute myeloid leukemia. APRIL (A Proliferation Inducing Ligand) is a member of the tumor necrosis factor superfamily that plays a key role in normal B-cell ...Désirée Bonci, Maria Musumeci, Valeria Coppola, Antonio Addario, Concetta Conticello, Michael Hahne, Massimo Gulisano, Francesco Grignani, Ruggero De Maria +8 moredoaj +1 more sourceMiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury +11 morewiley +1 more sourceDeletions of the derivative chromosome 9 occur at the time of the Philadelphia translocation and provide a powerful and independent prognostic indicator in chronic myeloid leukemia [PDF]
, 2001 Chronic myeloid leukemia (CML) is characterized by formation of the BCR-ABL fusion gene, usually as a consequence of the Philadelphia (Ph) translocation between chromosomes 9 and 22.Reid, AG, Campbell, LJ, Telford, N, Grace, C, Nacheva, EP, Shepherd, P, Szer, J, Green, AR, Bench, AJ, Prince, HM, Huntly, BJP, Turner, P +11 morecore De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways
Haematologica, 2019 Despite the advent of tyrosine kinase inhibitors, a proportion of chronic myeloid leukemia patients in chronic phase fail to respond to imatinib or to second-generation inhibitors and progress to blast crisis. Until now, improvements in the understanding Vera Magistroni, Mario Mauri, Deborah D’Aliberti, Caterina Mezzatesta, Ilaria Crespiatico, Miriam Nava, Diletta Fontana, Nitesh Sharma, Wendy Parker, Andreas Schreiber, David Yeung, Alessandra Pirola, Sara Readelli, Luca Massimino, Paul Wang, Praveen Khandelwal, Stefania Citterio, Michela Viltadi, Silvia Bombelli, Roberta Rigolio, Roberto Perego, Jacqueline Boultwood, Alessandro Morotti, Giuseppe Saglio, Dong-Wook Kim, Susan Branford, Carlo Gambacorti-Passerini, Rocco Piazza +27 moredoaj +1 more source
