In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice. [PDF]
, 2012 Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines.
Brentjens, Renier J. +12 more
core +6 more sources
Rapid and label-free identification of single leukemia cells from blood in a high-density microfluidic trapping array by fluorescence lifetime imaging microscopy. [PDF]
, 2018 The rapid screening and isolation of single leukemia cells from blood has become critical for early leukemia detection and tumor heterogeneity interrogation. However, due to the size overlap between leukemia cells and the more abundant white blood cells (
Digman, Michelle A +4 more
core +1 more source
Epidemiology of leukemia and multiple myeloma in golestan, Iran [PDF]
, 2013 Background: The aim of this paper was to present the incidence rates of leukemia and multiple myeloma (MM) in Golestan province located in northeastern Iran during 2004-2009. Materials and Methods: This was a descriptive cross-sectional study.
Jahangirrad, A. +5 more
core +1 more source
miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential. [PDF]
, 2018 We have shown that antagomiR inhibition of miRNA miR-21 and miR-196b activity is sufficient to ablate MLL-AF9 leukemia stem cells (LSC) in vivo. Here, we used an shRNA screening approach to mimic miRNA activity on experimentally verified miR-196b targets
Aronow, Bruce J. +15 more
core +2 more sources
Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKC subversion induces up-regulation of PKC II expression in B lymphocytes [PDF]
, 2015 Overwhelming evidence identifies the microenvironment as a critical factor in the development and progression of chronic lymphocytic leukemia, underlining the importance of developing suitable translational models to study the pathogenesis of the disease.
Cosimo, Emilio +10 more
core +3 more sources
CREB is a critical regulator of normal hematopoiesis and leukemogenesis [PDF]
, 2008 The cAMP-responsive element binding protein (CREB) is a 43-kDa nuclear transcription factor that regulates cell growth, memory, and glucose homeostasis. We showed previously that CREB is amplified in myeloid leukemia blasts and expressed at higher levels
Akashi +55 more
core +3 more sources
Kernel Logistic Regression-linear for Leukemia Classification Using High Dimensional Data [PDF]
, 2009 Kernel Logistic Regression (KLR) is one of the statistical models that has been proposed for classification in the machine learning and data mining communities, and also one of the effective methodologies in the kernel–machine techniques.
Embong, A. (A) +3 more
core +3 more sources
Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis [PDF]
, 2010 Background A substantial number of epidemiologic studies have provided estimates of the relation between exposure to benzene at work and the risk of leukemia, but the results have been heterogeneous.
A Le Noir +26 more
core +4 more sources
In vitro transformation of lymphoid cells by Abelson murine leukemia virus [PDF]
, 1975 Cell cultures prepared from fetal murine liver were infected by Abelson murine leukemia virus. After about 2 weeks, proliferating cells of lymphoid morphology appeared in some of the cultures.
Baltimore, David +2 more
core +2 more sources
A study on the isolation of leukemia virus of AKR mouse by fluorocarbon [PDF]
, 1962 The authors have succeeded in isolating a biologically-active leukemia virus from leukemic tissues of AKR mice with a fluorocarbon. From the chemical analysis of the biologically-active virus fraction it has been clarified that the AKR leukemia virus is ...
Miyoshi, Isao, Okada, Koichi
core +1 more source