Results 71 to 80 of about 1,360,875 (361)

S114: PONATINIB AND BLINATUMOMAB FOR PATIENTS WITH PHILADELPHIA CHROMOSOME-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA: UPDATED RESULTS FROM A PHASE II STUDY

HemaSphere, 2022
N. Short, H. Kantarjian, M. Konopleva, N. Jain, F. Ravandi, X. Huang, W. Macaron, W. Wierda, G. Borthakur, T. Kadia, K. Sasaki, G. Issa, G. Montalban-Bravo, Y. Alvarado, G. Garcia-Manero, C. Dinardo, J. Thankachan, R. Delumpa, E. Mayor, W. Deen, A. Milton, J. Rivera, L. Waller, C. Loiselle, R. Garris, E. Jabbour   +25 more
doaj   +1 more source

Serial assessment of suspected myelodysplastic syndromes: significance of flow cytometric findings validated by cytomorphology, cytogenetics, and molecular genetics

Haematologica, 2013
The significance of flow cytometry indicating myelodysplasia without proof of myelodysplasia by cytomorphology remains to be clarified. We evaluated follow-up analyses in 142 patients analyzed in parallel by flow cytometry, cytomorphology and ...
Wolfgang Kern, Claudia Haferlach, Susanne Schnittger, Tamara Alpermann, Torsten Haferlach   +4 more
doaj   +1 more source

Sulindac sulfide reverses aberrant self-renewal of progenitor cells induced by the AML-associated fusion proteins PML/RARalpha and PLZF/RARalpha [PDF]

, 2011
Chromosomal translocations can lead to the formation of chimeric genes encoding fusion proteins such as PML/RARalpha, PLZF/RARalpha, and AML-1/ETO, which are able to induce and maintain acute myeloid leukemia (AML). One key mechanism in leukemogenesis is
Hagemeyer, Heike, Maier, Thorsten Jürgen, Oancea, Claudia, Puccetti, Elena, Roos, Jessica, Ruthardt, Martin, Steinert, Gunnar   +6 more
core  

Not just a by‐product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B‐cell leukemia

Molecular Oncology, EarlyView.
Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley   +1 more source

P371: HYPER-CVAD WITH SEQUENTIAL BLINATUMOMAB, WITH OR WITHOUT INOTUZUMAB OZOGAMICIN, IN ADULTS WITH NEWLY DIAGNOSED PHILADELPHIA CHROMOSOME-NEGATIVE B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

HemaSphere, 2022
N. Short, H. Kantarjian, F. Ravandi, M. Yilmaz, T. Kadia, P. Thompson, X. Huang, M. Konopleva, A. Ferrajoli, N. Jain, K. Sasaki, Y. Alvarado, G. Borthakur, C. Dinardo, M. Ohanian, W. Macaron, S. Kornblau, M. Zhao, M. Kwari, C. Loiselle, R. Delumpa, A. Milton, J. Rivera, S. Lewis, R. Garris, E. Jabbour   +25 more
doaj   +1 more source

Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model. [PDF]

, 2011
The efficacy of resveratrol as a preventive agent against the growth of t(4;11) acute lymphoblastic leukemia (ALL) was evaluated in NOD.CB17-Prkdcscid/J mice engrafted with the human t(4;11) ALL SEM cell line.
Ducore, Jonathan M, Keen, Carl L, Newman, John W, Pedersen, Theresa L, Storms, David H, Zunino, Susan J   +5 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

S149: LONG TERM OUTCOMES OF IFCG REGIMEN FOR FIRSTLINE TREATMENT OF PATIENTS WITH CLL WITH MUTATED IGHV AND WITHOUT DEL(17P)/TP53 MUTATION

HemaSphere, 2022
N. Jain, P. Thompson, J. Burger, A. Ferrajoli, K. Takahashi, Z. Estrov, G. Borthakur, P. Bose, T. Kadia, N. Pemmaraju, K. Sasaki, M. Konopleva, E. Jabbour, N. Garg, X. Wang, R. Kanagal-Shamanna, K. Patel, W. Wang, S. Wang, J. Jorgensen, W. Lopez, A. Ayala, W. Plunkett, V. Gandhi, H. Kantarjian, S. O’Brien, M. Keating, W. Wierda   +27 more
doaj   +1 more source

Molecular analysis of myelodysplastic syndrome with isolated deletion of the long arm of chromosome 5 reveals a specific spectrum of molecular mutations with prognostic impact: a study on 123 patients and 27 genes

Haematologica, 2017
The only cytogenetic aberration defining a myelodysplastic syndrome subtype is the deletion of the long arm of chromosome 5, which, along with morphological features, leads to the diagnosis of myelodysplastic syndrome with isolated deletion of the long ...
Manja Meggendorfer, Claudia Haferlach, Wolfgang Kern, Torsten Haferlach   +3 more
doaj   +1 more source

FHL2 regulates hematopoietic stem cell functions under stress conditions. [PDF]

, 2015
FHL2, a member of the four and one half LIM domain protein family, is a critical transcriptional modulator. Here, we identify FHL2 as a critical regulator of hematopoietic stem cells (HSCs) that is essential for maintaining HSC self-renewal under ...
Chen, J, Fan, R, Hou, Y, Hou, Y, Jiang, Y, Li, L, Li, W, Mittal, N, Peace, D, Qian, Z, Wang, X, Wu, W, Zhu, T   +12 more
core   +2 more sources