Results 101 to 110 of about 152,467 (287)

Multivariate Screening and Automated Clustering of Macrophage Immunoreactome to Nanoparticles and Photothermal Therapy

Advanced Science, EarlyView.
Predicting immune responses to treatments, including nanomedicines, with high throughput test is challenging due to the immunoreactome's complexity and plasticity. A predictive screening platform integrating pathway activation and gene profiling in macrophages has been developed as a versatile tool for designing effective immunotherapies.
Sonia Becharef, Léa Jabbour, Nassima Bekaddour, Giulio Avveduto, Nathalie Luciani, Gautier Laurent, Rana Bazzi, Edouard Alphandery, Stéphane Roux, Amanda K. A. Silva, Kelly Aubertin, Jean‐Philippe Herbeuval, Florence Gazeau   +12 more
wiley   +1 more source

Enzyme-linked immunosorbent assay for post-slaughter diagnosis of bovine leukosis

Ветеринария сегодня
Postmortem diagnosis of enzootic bovine leukosis is made on the basis of the results of tests of biological materials from emergently slaughtered or fallen animals using pathomorphological, histological and molecular genetic methods that have some ...
A. R. Mustafayev, M. O. Baratov
doaj   +1 more source

Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5  proteins including human TRIM5 [PDF]

, 2009
The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5{
Anderson, Andrew Wood, Asaoka, Bainbridge, Bartosch, Bartosch, Bartosch, Benjamin L. J. Webb, Berthoux, Besnier, Birke Bartosch, Bock, Greg J. Towers, Hanger, Hatziioannou, Hatziioannou, Hatziioannou, Jonsson, Kaiser, Keckesova, Keckesova, Le Tissier, Lieber, Lin, Martin, Martin, Mortuza, Naviaux, Negre, Neil, Newman, Niebert, Nisole, Oldmixon, Passerini, Patience, Patience, Perez-Caballero, Perron, Rambaut, Sakuma, Schaller, Si, Song, Stoye, Stoye, Stremlau, Stremlau, Stremlau, Takeuchi, Tarlinton, Torsten Schaller, Towers, Towers, Towers, Wilson, Wu, Yap, Yasuhiro Takeuchi, Ylinen, Ylinen, Zufferey   +61 more
core   +2 more sources

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang, Xueying Wang, Shanhong Lu, Yan Gao, Gangcai Zhu, Guo Li, Zongnan Yu, Junwei Hou, Helei Yan, Wenhui Yuan, Xin Zhang, Mien‐Chie Hung, Zhifeng Liu, Yong Liu   +13 more
wiley   +1 more source

The bovine leukemia virus p34 is a transactivator protein. [PDF]

The EMBO Journal, 1987
Recombinant Moloney murine retroviruses containing the BLV post-envelope long open reading frame were constructed and transfected into the psi 2 packaging cell line. They were shown to encode and to express a 34-kd protein able to transactivate the BLV long terminal repeat-directed gene expression in the respective transfected cells.
Willems, Lucas, Gegonne, A., Chen, G, Burny, Arsène, Kettmann, Richard, Ghysdael, Jacques   +5 more
openaire   +3 more sources

Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors [PDF]

, 2010
Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV.
Atkins, H, Bell, JC, Breitbach, C, Cox, J, De Silva, N, Diallo, JS, Falls, T, Guimond, T, Huang, B, Kirn, D, Le Boeuf, F, MacTavish, H, McCart, AJ, Simmons, JG, Stanford, M, Thorne, S   +15 more
core   +1 more source

RIG‐I‐Inducing Small Molecules Potently Inhibit HMA‐Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Advanced Science, EarlyView.
This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen, Jiaqi Wu, Yuntong Li, Jiayu Huang, Xiangqin Weng, Jiale Wu, Shujun Xiao, Huaxin Song, Zhengyuan Wang, Ni Yan, Fangfang Shi, Derun Zheng, Kai Tan, Hesong Zhang, Jingyi Cui, Wen Wu, Wei Wu, Sujiang Zhang, Min Lu   +18 more
wiley   +1 more source

Pathobiology of bovine leukemia virus.

Veterinary research, 1994
Bovine leukemia virus (BLV) is a retrovirus similar to the human T-cell leukemia virus (HTLV). Most BLV infected animals (70%) develop a B-cell lymphoproliferative syndrome with altered productive traits and 1 to 5% die with B-cell lymphosarcomas. Although BLV infection is world-wide, western European countries have almost eradicated it by slaughtering
Schwartz-Cornil, Isabelle, Levy, Danielle   +1 more
openaire   +4 more sources

Homologies entre les deux rétrovirus BLV et HTLV-1 et développement d’une nouvelle approche thérapeutique basée sur la levée de la latence virale [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2007
Homologies between BLV and HTLV-1 retroviruses and development of a novel therapeutic approach based on induction of viral expression. BLV (bovine leukemia virus) and HTLV-1 (human T-cell leukemia virus) are related retroviruses inducing leukemia (BLV ...
Nicolas Gillet, Luc Willems, Richard Kettmann   +2 more
doaj  

Activation of Lysosomal Retrograde Transport Triggers TPC1‐IP3R1 Ca2+ Crosstalk at Lysosome‐ER MCSs Leading to Lethal Depleting of ER Calcium

Advanced Science, EarlyView.
The flavonoid compound LW‐213 exerts its antitumor effects through a novel mechanism involving lysosomal‐ER calcium regulation. Specifically, LW‐213 binds to LIMP2, which induces perinuclear clustering of lysosomes and facilitates calcium‐mediated lysosome‐ER interactions.
Meng‐yuan Zhu, Yong‐jian Guo, Yu‐qi Zhu, Hong‐zheng Wang, Hai‐di Wang, Hong‐yu Chen, Yue‐xin Jiang, Hui Li, Hui Hui   +8 more
wiley   +1 more source