Results 81 to 90 of about 61,162 (207)

Earlier onset of delta-retrovirus-induced leukemia after splenectomy.

PLoS ONE, 2009
Infection by delta-retroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) is mostly asymptomatic. Indeed, only a minority (
Arnaud Florins, Michal Reichert, Becca Asquith, Amel-Baya Bouzar, Geneviève Jean, Carole François, Agnieszka Jasik, Arsène Burny, Richard Kettmann, Luc Willems   +9 more
doaj   +1 more source

Satellite Glial Cells Synthesize and Release GABA to Activate Extrasynaptic GABAA Receptors That Modulate Dorsal Root Ganglia Neuron Excitability

Glia, Volume 74, Issue 9, September 2026.
Mechanism of synthesis, release, receptor activation, uptake, and degradation of GABA in dorsal root ganglia (DRG). Left: GABA is synthesized from putrescine in satellite glial cells (SGCs). After being released by Best1 channel, it activates GABAA receptors in sensory neurons, producing a chloride current.
Natalie Jiménez‐Barrios, Ricardo González‐Ramírez, Francisco Javier Paz‐Bermúdez, Guadalupe Raya‐Tafolla, José Segovia Vila, Ricardo Felix, Rodolfo Delgado‐Lezama, Benjamín Florán Garduño   +7 more
wiley   +1 more source

The viral origins of breast cancer

Infectious Agents and Cancer
During the past two decades evidence has been developed that indicates a handful of viruses with known oncogenic capacity, have potential roles in breast cancer.
James S. Lawson, Wendy K. Glenn
doaj   +1 more source

Unveiling the Functional Role of KIF21B in Microglia Inflammatory Response

Glia, Volume 74, Issue 9, September 2026.
Microglia express KIF21B in both sexes. KIF21B binds to microglia cytoskeleton; inflammation alters such interaction promoting a phagocytic state in females. In male microglia KIF21B modulates migration. ABSTRACT Microglia are brain immune cells that maintain homeostasis and respond to injury, changing cell morphology to drive inflammation, migration ...
Danny Ganchala, Alvaro Bautista‐Abad, Daniel Pinto‐Benito, Julia Simon‐Areces, Daniela Grassi, Francesco Paolo Ulloa Severino, Maria‐Angeles Arevalo   +6 more
wiley   +1 more source

DNA Replication Stress‐Induced Transcriptome of Human Burkitt's Lymphoma Identifies Reciprocal Regulation Between MBD1 and BCL6 During Germinal Center‐Derived B‐Lymphomagenesis

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT BCL6 is a master transcriptional regulator of germinal center (GC) B cells. BCL6 is frequently translocated at the major translocation cluster (MTC) within intron 1 of the BCL6 locus, a hotspot commonly rearranged in diffuse large B cell lymphomas (DLBCLs).
Santosh Kumar Gothwal, Kyoko Oichai, Hongtae Kim, Kyungjae Myung, Jacqueline H. Barlow   +4 more
wiley   +1 more source

Seroprevalence and Presumed Bovine Leukaemia Virus and Coxiella burnetii Coinfections in Three Dairy Cattle Herds From the Al Ain Region, United Arab Emirates

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
ABSTRACT Background Bovine leukaemia virus (BLV) and Coxiella burnetii are important infectious pathogens of dairy cattle with potential implications for animal health, productivity and zoonotic transmission (in the case of C. burnetii). Because BLV may alter immune function, we hypothesize that infection with the virus could increase cattle ...
Robert Barigye, Nabeeha A. Hassan, Asha Antony, Aboma Zewude, Ibrahim M. Abdalla‐Alfaki, Omar A. M. Alawadhi, Abdulrahman A. A. Amer, Manar S. N. Binsumaida, Maram S. S. Alshamsi, Hamda S. H. Alderei, Meera S. Al Kalbani, Oum K. Bensalah, Shamma A. Alnaqbi, Gobena Ameni   +13 more
wiley   +1 more source

Investigation of bovine leukemia virus transmission pathways within dairy herds through analysis of genomic and epidemiological data

Journal of Dairy Science
: Bovine leukemia virus (BLV) is a highly prevalent retrovirus in US dairy cattle herds and has negatively affected dairy herds by reducing milk production, increasing culling rates, and contributing to economic losses. The objective of this study was to
B.M. Nyokabi, A. Kumari, J. Nirmala, V.K. Singh, S.M. Goyal, S.K. Mor, N.M. Sobhy, D.C. Schroeder, S.J. Wells   +8 more
doaj   +1 more source

Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa‐Cell Programs

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
PKC‐mediated phosphorylation of FOXL2 weakens DNA binding, alters subnuclear localization and protein interactions, and reshapes FOXL2‐dependent transcriptional programs in granulosa cells, supporting a reversible mechanism that modulates FOXL2 activity through phosphorylation of its DNA‐binding domain. ABSTRACT FOXL2 is a forkhead transcription factor
Ludovic Mousseron, Despoina Chousianiti, Francis Poulat, Bérangère Legois, Reiner A. Veitia, Anne‐Laure Todeschini   +5 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, Volume 16, Issue 8, Page 1509-1526, August 2026.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, Volume 13, Issue 44, 7 August 2026.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source