Results 71 to 80 of about 1,530,725 (262)

Transmission of Bovine Leukemia Virus By Rectal Palpation: Control and Epidemiologic Studies

, 1992
Bovine Leukemia Virus (BLV), a C-type retrovirus, is horizontally spread in cattle by infected lymphocytes.[1] Infection with the BLV is lifelong. Several routine management procedures have been implicated in the transmission of BLV, especially manual ...
Divers, Thomas J.
core   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

What dairy veterinarians should know about bovine leukemia virus

, 2018
Bovine leukemia virus (BLV) is now present in almost all US dairy herds, and the prevalence among cattle in our milking herds is now approaching 50%.
Hutchinson, Holden M., Barlett, Paul C., LaDronka, Rebecca M., Ruggiero, Vickie J.   +3 more
core   +1 more source

Enzyme-linked immunosorbent assay for post-slaughter diagnosis of bovine leukosis

Ветеринария сегодня
Postmortem diagnosis of enzootic bovine leukosis is made on the basis of the results of tests of biological materials from emergently slaughtered or fallen animals using pathomorphological, histological and molecular genetic methods that have some ...
A. R. Mustafayev, M. O. Baratov
doaj   +1 more source

Bovine leukemia virus G4 enhances virus production

Virus Research, 2017
The nonstructural G4 gene of bovine leukemia virus (BLV) has been thought to function in virus replication. However, the discovery of the AS1 gene on the antisense strand of the G4 gene has affected this interpretation. In this study, we investigated the function of G4 in virus production independent of the AS1 gene using a reverse genetic approach ...
Hironobu, Murakami, Shotaro, Asano, Jumpei, Uchiyama, Reiichiro, Sato, Masahiro, Sakaguchi, Kenji, Tsukamoto   +5 more
openaire   +2 more sources

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

Functional interactions of the Tax and p13 proteins of Human T-cell Leukemia Virus Type I [PDF]

, 2013
Human T-cell leukemia virus type 1 (HTLV-1) establishes a lifelong persistent infection in humans. Approximately 3% of the infected individuals will develop adult T-cell leukemia/lymphoma (ATLL), an aggressive malignancy of mature CD4+ T-cells. The viral
Manicone, Mariangela
core  

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Bulls as a source of bovine leukemia virus during natural breeding

, 2018
Bovine leukosis is a chronic lymphoproliferative disorder in cattle caused by the deltaretrovirus, bovine leukemia virus (BLV). Most BLV infected animals remain asymptomatic and act as carriers of the virus; 30 to 40% of infected cattle develop  a ...
Maeroff, J. E., Benitez, O. J., Norby, B., Bartlett, P., Grooms, D. L., Roberts, J.   +5 more
core   +1 more source

Murine leukemia virus (MLV) replication monitored with fluorescent proteins [PDF]

, 2006
Background: Cancer gene therapy will benefit from vectors that are able to replicate in tumor tissue and cause a bystander effect. Replication-competent murine leukemia virus (MLV) has been described to have potential as cancer therapeutics, however, MLV
Erlwein, Otto, Bittner, Alexandra, Sliva, Katja, Schnierle, Barbara   +3 more
core   +1 more source