Results 131 to 140 of about 152,467 (287)

PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation

Advanced Science, EarlyView.
Hijacking Host Kinase PIM1: A β‐Coronavirus (OC43) strategy to degrade IFNAR1 and evade antiviral immunity. Human β‐coronaviruses (OC43) exploit the proto‐oncoprotein PIM1 kinase to sabotage innate immunity. Viral RNA/proteins upregulate PIM1, which phosphorylates E3 ligase β‐TrCP1.
Qianya Wan, Lin Zhu, Cien Chen, Li Zhong, Houying Leung, Wei Li, Chang Xu, Xi Yao, Huan Hu, Mandi Wu, Yuxin Hou, Hin Chu, Yiran Wang, Sheng Chen, Mingyu Pan, Zongwei Cai, Ming‐liang He   +16 more
wiley   +1 more source

Regulation of alphaherpesvirus infections by the ICP0 family of proteins [PDF]

, 2013
Immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1) is important for the regulation of lytic and latent viral infection. Like the related proteins expressed by other alphaherpesviruses, ICP0 has a zinc-stabilized RING finger domain that ...
Boutell, Chris, Everett, Roger
core   +1 more source

Bovine leukemia virus detection in humans: A systematic review and meta-analysis

Virus Research, 2023
Willington Mendoza, J. P. Isaza, Lucelly López, A. López-Herrera, L. Gutiérrez   +4 more
semanticscholar   +1 more source

Nanomaterials Trigger Functional Anti‐Tumoral Responses in Primary Human Immune Cells

Advanced Science, EarlyView.
Nanoparticles are used to improve immunomodulatory therapies, but the impact of drug‐free nanomaterials on the immune system remains unknown. Screening common biomedical nanoparticles (NPs) reveals that PLGA NPs enhanced NK cell anti‐tumoral activity and transcriptional activation in human NK and pan T cells.
Vincent Mittelheisser, Olivier Lefebvre, Mainak Banerjee, Shayamita Ghosh, Amandine Dupas, Marie‐Charlotte Diringer, Juliette Blumberger, Louis Bochler, Sébastien Harlepp, Annabel Larnicol, Angélique Pichot, Tristan Stemmelen, Anne Molitor, Chloé Moritz, Christine Carapito, Raphaël Carapito, Loïc J. Charbonnière, François Lux, Olivier Tillement, Jacky G. Goetz, Alexandre Detappe   +20 more
wiley   +1 more source

Lung adenocarcinoma originates from retrovirus infection of proliferating type 2 pneumocytes during pulmonary post-natal development or tissue repair [PDF]

, 2011
Jaagsiekte sheep retrovirus (JSRV) is a unique oncogenic virus with distinctive biological properties. JSRV is the only virus causing a naturally occurring lung cancer (ovine pulmonary adenocarcinoma, OPA) and possessing a major structural protein that ...
A Giangreco, A Harris, A Ortin, A Winkelmann, AB Bahnson, AD Miller, AL Payne, AS Zolotukhin, B Chessa, BB Zhou, BJ Bradley, C Cousens, C Johnson, CF Kim, CG Plopper, Claudio Murgia, D Salvatori, DG Miller, DI Nisbet, DW Verwoerd, E Beytut, EL Rawlins, EL Rawlins, F Arnaud, F Arnaud, F Schwenter, G Zavala, Gabriella Di Francesco, H Fan, JA Platt, JA Whitsett, JC DeMartini, JE Donello, JE Visvader, JM Coffin, JM Sharp, JM Sharp, JP Scheerlinck, K McGee-Estrada, K McGee-Estrada, K McGee-Estrada, K Perk, K Quade, L Naldini, LH Rosai JaS, M Bray, M Caporale, M Caporale, M Caporale, M De Las Heras, M De las Heras, M Palmarini, M Palmarini, M Palmarini, M Palmarini, M Palmarini, M Palmarini, M Palmarini, M Palmarini, M Palmarini, Marcelo de las Heras, Marco Caporale, Massimo Palmarini, MF Clarke, MH Kubbutat, Michael Emerman, MJ Holland, N Maeda, N Maeda, N Maeda, N Rosenberg, Nicola Ferri, Ousman Ceesay, P Banerjee, PF Lewis, RM Dakessian, RP Hill, S Zaffran, SK Rai, SK Rai, SK Wootton, SK Wootton, SL Kauffman, SL Liu, SL Liu, SL Liu, SL Liu, T Reya, T Roe, TB Zeltner, TB Zeltner, TE Allen, U O'Doherty, Vincenzo Varasano   +93 more
core   +6 more sources

CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD‐1 Blockade

Advanced Science, EarlyView.
This study demonstrates that engineering CAR T cells to express CXCL13 enhances their antitumor efficacy and significantly improves responsiveness to PD‐1 immune checkpoint blockade. CXCL13 promotes T cell persistence, and resistance to early exhaustion via the AKT‐mTOR pathway.
Yang Zhou, Wenli Zhao, Yihan Zhu, Hongyan Liu, Yicheng Sun, Zhengrong Gong, Xuanyi Li, Ziying Liu, Kang Wen, Yicheng Wang, Jie Ren, Ruipei Xiao, Ling Jiang, Yanfeng Hu, Enguang Bi, Xiaoyong Zhang   +15 more
wiley   +1 more source

Detection of bovine leukemia virus in pasteurized milk from a number of industrial milk factories in Iran by Nested Polymerase Chain Reaction (PCR)

Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī
Bovine leukemia virus (BLV) as the causative agent of enzootic bovine leukosis (EBL) is a retrovirus which is closely related to type 1 and 2 leukemia virus of human T cells and it is also considered as a possible cause of breast cancer in women.
Shobeir Yazdani Paraei, mohammad rahim hajikolayei, masoudreza Siefi abad shapori, Mohammad Nouri, Faramarz Beheshtifar, ُSima Şahinduran   +5 more
doaj  

Earlier onset of delta-retrovirus-induced leukemia after splenectomy.

PLoS ONE, 2009
Infection by delta-retroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) is mostly asymptomatic. Indeed, only a minority (
Arnaud Florins, Michal Reichert, Becca Asquith, Amel-Baya Bouzar, Geneviève Jean, Carole François, Agnieszka Jasik, Arsène Burny, Richard Kettmann, Luc Willems   +9 more
doaj   +1 more source

Investigating Virus Clearance via pH Inactivation During Biomanufacturing [PDF]

, 2019
In the processing of biopharmaceuticals, viral clearance and viral safety are important for the development of monoclonal antibodies. Murine xenotropic leukemia virus (XMuLV) is one of the retroviruses, recommended by Food and Drug Administration (FDA ...
Xu, Wenbo
core   +2 more sources

Bispecific Nanosystems Enable Multieffector Immune Cell Retargeting for Hematologic Malignancy Therapy

Advanced Science, EarlyView.
B‐cell lymphomas are aggressive malignancies with limited treatment options. A bispecific nanosystem (biHSNPs) is developed, leveraging silica nanoplatforms to conjugate antibodies targeting immune effector cells and B‐cell antigens. biHSNPs form artificial immunological synapses, activating cytotoxic responses and suppressing tumor proliferation. This
Yefeng Shen, Xin Li, Jingnan Wu, Yuru Ma, Sven Borchmann, Zhenguo Cheng, Yaohe Wang, Yongliang Zhao, Jian Song, Boyu Luo, Xiuyun Liu, Yue Teng, Zhiyuan Shi   +12 more
wiley   +1 more source