Results 1 to 10 of about 5,469 (115)
Panton-Valentine Leukocidin–Encoding Methicillin-Resistant Staphylococcus aureus, the Netherlands, 2023–2024 [PDF]
Emerging Infectious DiseasesWe describe a community outbreak of Panton-Valentine leukocidin–positive methicillin-resistant Staphylococcus aureus (MRSA) during November 2023–June 2024 in the Netherlands. We identified a massage center as the source.
Patrick van Schelven +11 more
doaj +2 more sources
TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection
Frontiers in Immunology, 2023 BackgroundAn essential fact underlying the severity of Staphylococcus aureus (S. aureus) infection is the bicomponent leukocidins released by the pathogen to target and lyse host phagocytes through specific binding cell membrane receptors.
Xianggui Yang, Yang Xianggui
exaly +3 more sources
Vibrio pore-forming leukocidin activates pyroptotic cell death via the NLRP3 inflammasome
Emerging Microbes and Infections, 2020 Cell death mechanisms are central to combat infections and to drive inflammation. The inflammasome controls infection through activation of caspase-1 leading to either IL-1β dependent inflammation, or pyroptotic cell death in infected cells.
Motti Gerlic +2 more
exaly +3 more sources
Skin Infections Caused by Panton-Valentine Leukocidin and Methicillin-Susceptible Staphylococcus aureus in Child, Japan [PDF]
Emerging Infectious DiseasesWe describe a pediatric case of recurrent skin infections caused by a Panton-Valentine leukocidin and exfoliative toxin E double-positive methicillin-susceptible Staphylococcus aureus clonal complex 188 clone.
Kensuke Shoji +11 more
doaj +2 more sources
mAbs, 2022 Staphylococcus aureus carries an exceptional repertoire of virulence factors that aid in immune evasion. Previous single-target approaches for S.
Shweta Kailasan +11 more
doaj +1 more source
Frontiers in Immunology, 2023 Atypical chemokine receptor-1 (ACKR1), previously known as the Duffy antigen receptor for chemokines, is a widely conserved cell surface protein that is expressed on erythrocytes and the endothelium of post-capillary venules.
Xinying Guo +17 more
doaj +1 more source
Studying Staphylococcal Leukocidins: A Challenging Endeavor
Frontiers in Microbiology, 2020 Staphylococcus aureus is a well-known colonizer of the human skin and nose, but also a human pathogen that causes a wide spectrum of diseases. It is well established that S.
Angelino T. Tromp, Jos A. G. van Strijp
doaj +1 more source
mBio, 2019 Staphylococcus aureus is a human pathogen responsible for high morbidity and mortality worldwide. Recurrent infections with this bacterium are common, suggesting that S. aureus thwarts the development of sterilizing immunity. S. aureus strains that cause
Evelien T. M. Berends +6 more
doaj +1 more source
Journal of Acute Disease, 2020 Objective: To identify the pathogenic gene of Panton-Valentine leukocidin in methicillin-resistant Staphylococcus aureus strain isolated from clinical specimens of burn patients in Shaheed Zare Burn Hospital.
Atefeh Ranjkesh +16 more
doaj +1 more source
Host–Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity
Toxins, 2020 Staphylococcal bi-component pore-forming toxins, also known as leukocidins, target and lyse human phagocytes in a receptor-dependent manner. S-components of the leukocidins Panton-Valentine leukocidin (PVL), γ-haemolysin AB (HlgAB) and CB (HlgCB ...
Angelino T. Tromp +13 more
doaj +1 more source