Results 171 to 180 of about 1,703,142 (356)

Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs

Advanced Healthcare Materials, EarlyView.
This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani, Aaron R. J. Hutton, Peter E. McKenna, Eneko Larrañeta, Ryan F. Donnelly   +4 more
wiley   +1 more source

Haematocrit, leukocyte and platelet counts and the severity of the ovarian hyperstimulation syndrome [PDF]

, 1998
F. Fàbregues, Juan Balasch, Dolors Manau, Wladimiro Jiménez, Vicente Arroyo, Montse Tuset Creus, Francisca Rivera, Juan A. Vanrell   +7 more
openalex   +1 more source

Multiscale Profiling of Nanoscale Metal‐Organic Framework Biocompatibility and Immune Interactions

Advanced Healthcare Materials, EarlyView.
A multi‐scale, hierarchical ‘Safety‐by‐Design’ pipeline combining machine learning, ex vivo human blood assays, and in vivo models enables the systematic immunotoxicity and biocompatibility profiling of nanoscale metal‐organic frameworks, accelerating their safe clinical translation. Abstract The clinical translation of metal‐organic frameworks (MOFs) –
Yunhui Zhuang, Bárbara B. Mendes, Dhruv Menon, Jhenifer Oliveira, Xu Chen, Fatma Demir Duman, João Conniot, Sergio Mercado, Xiewen Liu, Shi‐Yuan Zhang, João Conde, Rachel E. Hewitt, David Fairen‐Jimenez   +12 more
wiley   +1 more source

Detection of leukocytes stained with acridine orange using unique spectral features acquired from an image-based spectrometer [PDF]

, 2017
A leukocyte differential count can be used to diagnosis a myriad blood disorders, such as infections, allergies, and efficacy of disease treatments. In recent years, attention has been focused on developing point-of-care (POC) systems to provide this ...
Hunter, Courtney J
core   +2 more sources

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

Advanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah, Remant KC, Amarnath Praphakar Rajendran, Saba Abbasi Dezfouli, Cezary Kucharski, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Olaf Heidenreich, Hasan Uludağ   +9 more
wiley   +1 more source

Altered leukocyte blood count in COVID-19 pandemic period

Инфекция и иммунитет
Relevance. A potential for zoonotic transmission of highly pathogenic coronavirus strains to humans was of little concern to health care providers, which came as a surprise and led to a coronavirus pandemic in 2020 spring.
Sergey N. Kostarev, T. G. Sereda
doaj   +1 more source

Interaction between the PI3K/AKT pathway and mitochondrial autophagy in macrophages and the leukocyte count in rats with LPS-induced pulmonary infection. [PDF]

Open Life Sci, 2023
Wu C, Guo L, Muhataer X, Li Q, Lian Z, Li Y, Wang W, Ding W, Zhou Y, Yang X, Chen M.   +10 more
europepmc   +1 more source

Aspects of leucocyte and fat filtration during cardiac surgery [PDF]

, 2005
Na een hartoperatie treden vaak door het hele lichaam ontstekingsreacties op. Door het bloed tijdens de operatie te filteren, lopen patiënten minder risico op beschadigingen in longen, hart en hersenen, ontdekte Hans de Vries.
Vries, Adrianus Johannes de,
core   +3 more sources

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

Association between preoperative serum C-reactive protein level and leukocyte count and postoperative pain after otolaryngological surgery. [PDF]

Eur Arch Otorhinolaryngol, 2023
Geißler K, Brock R, Meißner W, Kiehntopf M, Guntinas-Lichius O.   +4 more
europepmc   +1 more source