Results 61 to 70 of about 40,537 (270)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

A novel algorithm for segmentation of leukocytes in peripheral blood [PDF]

Biomedical Signal Processing and Control, 2018, 45:10-21, 2019
In the detection of anemia, leukemia and other blood diseases, the number and type of leukocytes are essential evaluation parameters. However, the conventional leukocyte counting method is not only quite time-consuming but also error-prone. Consequently, many automation methods are introduced for the diagnosis of medical images. It remains difficult to
arxiv  

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Platelet count in men with a habit of alcohol drinking

Platelets, 2020
Alcohol inhibits platelet function, and platelet count is often reduced in individuals with alcohol use disorder. However, the relation of habitual alcohol drinking with platelet count in a general population remains to be determined.
Ichiro Wakabayashi
doaj   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

THE VALUE OF THE DIFFERENTIAL LEUKOCYTE COUNT IN DIAGNOSIS [PDF]

The American Journal of the Medical Sciences, 1906
n ...
openaire   +2 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Relationship between high leukocyte count and cell size in childhood acute myeloblastic leukemia

The Turkish Journal of Pediatrics, 1999
In order to determine the significance of cell size together with high leukocyte count (>30x10(9)/L) in acute myeloblastic leukemia (AML), we evaluated the percentages of small, medium and large cells in 33 children with AML.
L Olcay, U Ertem, H Okur, I Etikan, A M Tuncer   +4 more
doaj  

Spironolactone-Induced Agranulocytosis: A Case Report

Kaohsiung Journal of Medical Sciences, 2003
A 43-year-old woman with liver cirrhosis and hepatocellular carcinoma was admitted for the chief problem of ascites. Laboratory data revealed a leukocyte count of 3.8 × 109/L on the second day of admission.
Shu-Hwa Hsiao, May-Ying Hsu
doaj   +1 more source

A NEW DIFFERENTIAL LEUKOCYTE COUNT CHART [PDF]

JAMA: The Journal of the American Medical Association, 1913
In the earlier days of hematology it was supposed that the leukocyte count was a quite reliable guide to the extent, progress and severity of various infections. It was shortly recognized, however, that other factors entered into the problem and that the degree of leukocytosis was more of an index of the amount of resistance, the fighting force ...
openaire   +2 more sources