Results 121 to 130 of about 237,141 (361)
Statins and the vasculopathy of systemic sclerosis: potential therapeutic agents? [PDF]
, 2006 It has been postulated that endothelial cell injury is the initiating event in the pathogenesis of systemic sclerosis, causing attraction, attachment, migration and infiltration of activated T-cells and subsequent production of cytokines and growth ...
Derk, Chris T., Jimenez, Sergio A.
core +2 more sources
Advanced Science, EarlyView.The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu +13 more
wiley +1 more source
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats [PDF]
Journal of Neurochemistry 100(4): 1108-1120 (2007), 2007 Several studies suggest that cyclooxygenase (COX)-2 plays a pivotal role in the progression of ischaemic brain damage. In the present study, we investigated the effects of selective inhibition of COX-2 with nimesulide (12 mg/kg) and selective inhibition of COX-1 with valeryl salicylate (VAS, 12-120 mg/kg) on prostaglandin E2 (PGE2) levels ...
arxiv
Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy
Advanced Science, EarlyView.In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao +12 more
wiley +1 more source
Editorial: NK cell defects: diagnosis and treatment
Frontiers in Immunology, 2023 Snehal Shabrish +3 more
doaj +1 more source
Individual heat map assessments demonstrate vestronidase alfa treatment response in a highly heterogeneous mucopolysaccharidosis VII study population. [PDF]
, 2019 Mucopolysaccharidosis (MPS) VII is an ultra-rare, progressively debilitating, life-threatening lysosomal disease caused by deficiency of the enzyme, β-glucuronidase. Vestronidase alfa is an approved enzyme replacement therapy for MPS VII. UX003-CL301 was
Bauer, Mislen +7 more
core +1 more source
Advanced Science, EarlyView.This study uses gut microbiome data to predict corticosteroid response in patients with immune thrombocytopenia (ITP). Fecal samples from 212 patients with ITP are sequenced. Six machine‐learning algorithms are used to train predictive models. The support vector machine‐based model integrated clinical data and selected microbial species, diversities ...
Feng‐Qi Liu +38 more
wiley +1 more source
Mediators of Inflammation, 2015 Inflammatory processes are implicated in many diseases of the vasculature and have been shown to play a key role in the formation of intracranial aneurysms (IAs).
David M. Sawyer +3 more
doaj +1 more source
Advanced Science, EarlyView.Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong +20 more
wiley +1 more source
RESPIRATORY SYNCYTIAL VIRUS INFECTION: CLINICAL AND LABORATORY FEATURES
Детские инфекции (Москва), 2017 Infants are dominated among patients with respiratory syncytial viral infection (RSVI). In patients with RSVI characteristic are lesions of the lower respiratory tract and development of bronchial obstruction.
E. V. Mikhaylova +4 more
doaj +1 more source