Results 151 to 160 of about 164,678 (257)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Analysis of Platelet Membrane Glycoproteins and The Specific Antibodies in MYH9-Related Diseases. [PDF]

Int J Gen Med
Wang L, Cao K, Chen S, Fu X, Chen Y, Luo X.   +5 more
europepmc   +1 more source

Leukocyte Alkaline Phosphatase in Hematological Disorders

Leukocyte Alkaline Phosphatase in Hematological Disorders
Leukocyte alkaline phosphatase activity was studied biochemically and histochemically in various blood diseases. 1) N-APA is preferable to LAPA as a unit of biochemical measurement. 2) The low content of leukocyte AP in CGL was confirmed. The determination of leukocyte AP is useful in the diagnosis and treatment of CGL. 3) The low N-APA in CGL rises to
openaire  

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Platelet extravasation in the microvasculature: an under-appreciated role for platelets. [PDF]

Front Immunol
Courson JA, Afshar-Kharghan V, Burns AR, Rumbaut RE.   +3 more
europepmc   +1 more source

A Dispersant‐Driven Carbon‐Binder Domains Homogeneity in High‐Energy‐Density Electrodes for Lithium‐Ion Batteries

Advanced Science, EarlyView.
A polar dispersant, aromatic‐functionalized polyacrylate (AFPA), enables the formation of a uniform CBD network by enhancing miscibility with PVDF and suppressing phase separation. This leads to α‐phase crystallization of PVDF and aligned CNT networks within the CBD, resulting in well‐connected structures that improve cohesion, electron/ion transport ...
Da‐Sol Kwon, Min Young Seo, Jinho Ahn, Yea‐Ji Jeong, Woohyeon Shin, Wonseok Ko, Min Jeong Kim, Jiny Lee, Won‐Yong Jeon, Min‐Jae Choi, Kwang In Kim, Jin Ju Eom, Sang Yeop Oh, Honghee Lee, Joona Bang, Jongsoon Kim, YongJoo Kim, Jung‐Keun Yoo   +17 more
wiley   +1 more source

Recognition and Management of Transfusion-Associated Immune Hemolytic Crisis in Pregnant Patients with Thalassemia: Analysis of Three Cases and Construction of a Clinical Pathway. [PDF]

Int J Womens Health
Li H, Huang L, Li L.
europepmc   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source