Results 171 to 180 of about 164,678 (257)

Investigation of human leukocyte antigen alleles as risk factors for cryptococcal disease in Ugandan individuals with HIV. [PDF]

Hum Immunol
Skipper CP, Dai B, Borges B, Augusto DG, Gerlach E, Tukundane A, Tadeo K, Pastick KA, Williams DA, Kabahubya M, Rajasingham R, Nalintya E, Meya DB, Boulware DR, Hollenbach J, Nielsen K.   +15 more
europepmc   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Development of a predictive model integrating urogenital pathogens and inflammatory markers for human papillomavirus infection. [PDF]

Front Cell Infect Microbiol
Zhang J, Jiang B, Tao J, Chen M, Xiao S, Gong Y.   +5 more
europepmc   +1 more source

Integrating Reinforcement Learning With Explainable Artificial Intelligence for Real‐Time Clinical Decision Support in Dynamic Healthcare Environments

Advanced Intelligent Systems, EarlyView.
A hybrid Reinforcement Learning–Explainable AI framework integrates SHAP and LIME explanations directly into a Deep Q‐Network inference loop for real‐time ICU decision support. Trained on 18 142 mechanically ventilated stays from the eICU database, the system attains 93.0% decision accuracy, 20% fewer errors than RL alone, and a 91% clinician trust ...
Jannatul Ferdaus Disha, MD Faiaz Zaman Dehan, Kazi Md. Tanvir Anzum   +2 more
wiley   +1 more source

Harnessing Regulatory T Cells to Modulate Acute Brain Injury: From Mechanisms to Therapy. [PDF]

Mol Neurobiol
Ansari J, Sasannia S, Matsyuk M, Jackson C, Nyquist P.   +4 more
europepmc   +1 more source

Prevalence and Specificity of Anti-HPA and Anti-HLA Antibodies in Patients with Suspected Immune-Mediated Platelet Disorders: A Single-Center Study from Serbia. [PDF]

Medicina (Kaunas)
Vojvodić S, Grujić J.
europepmc   +1 more source

Melatonin Levels in 89 Individuals With Smith Magenis Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT In patients with Smith–Magenis syndrome (SMS), an inverted circadian rhythm of melatonin (MT) contributes to the sleep disturbance. Standard treatment of sleep disturbance with MT often leads to extremely high daytime MT levels, resulting in even more sleep disorders. We therefore retrospectively evaluated the MT data of 89 SMS patients.
Wiebe Braam, Ann C. M. Smith
wiley   +1 more source

Case Report: Ofatumumab for the treatment of refractory anti-NMDAR-positive autoimmune encephalitis. [PDF]

Front Immunol
Ma Y, Tang Y, Peng Q, Zhang W, Wu Y, Chen J, Xiong S, Lv D.   +7 more
europepmc   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

Relative Leukocyte Telomere Length Is Associated with Multimorbidity Burden in Older Adults: Evidence for Sex-Specific Associations. [PDF]

Int J Mol Sci
La Grotta R, Crocco P, Leonova A, Dato S, Passarino G, Rose G.   +5 more
europepmc   +1 more source