DNA methylation analysis of the angiotensin converting enzyme (ACE) gene in major depression. [PDF]
, 2012 The angiotensin converting enzyme (ACE) has been repeatedly discussed as susceptibility factor for major depression (MD) and the bi-directional relation between MD and cardiovascular disorders (CVD).
Baghai, Thomas C. +11 more
core +20 more sources
Local oxidative and nitrosative stress increases in the microcirculation during leukocytes-endothelial cell interactions. [PDF]
PLoS ONE, 2012 Leukocyte-endothelial cell interactions and leukocyte activation are important factors for vascular diseases including nephropathy, retinopathy and angiopathy.
Saptarshi Kar, Mahendra Kavdia
doaj +1 more source
Changes in Circadian Rhythms Dysregulate Inflammation in Ageing: Focus on Leukocyte Trafficking
Frontiers in Immunology, 2021 Leukocyte trafficking shows strong diurnal rhythmicity and is tightly regulated by circadian rhythms. As we age, leukocyte trafficking becomes dysregulated, contributing to the increased systemic, low-grade, chronic inflammation observed in older adults.
Poppy Nathan +3 more
doaj +1 more source
Platelet-leukocyte interactions: immunoregulatory role and pathophysiological relevance
Медицинская иммунология, 2022 Blood platelets are the central players in thrombosis and blood coagulation. Moreover, they also exhibit immunoregulatory properties and bridge hemostasis and immunity.
O. V. Pavlov +3 more
doaj +1 more source
Role of Human Leukocyte Antigen Class II in Antibody-Mediated Skin Disorders
Medicina, 2023 HLA class II molecules are key factors determining susceptibility to autoimmune disorders, and their role in immune-mediated skin conditions such as psoriasis has been extensively investigated.
Alvise Sernicola +5 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundTelomere length (TL) has been recognized to be fundamental to the risk of autoimmune disorders. However, the role of leukocyte TL in Graves’ disease has not yet been fully elucidated.
Meijie Ye, Yu Wang, Yiqiang Zhan
doaj +1 more source
Finite element methods for large-strain poroelasticity/chemotaxis models simulating the formation of myocardial oedema [PDF]
Journal of Scientific Computing, volume 92, paper 92, year 2022, 2021 In this paper we propose a novel coupled poroelasticity-diffusion model for the formation of extracellular oedema and infectious myocarditis valid in large deformations, manifested as an interaction between interstitial flow and the immune-driven dynamics between leukocytes and pathogens.
arxiv +1 more source
Anxiety: An overlooked confounder in the characterisation of chronic stress-related conditions?
PLoS ONE, 2020 Although anxiety disorders are among the most prevalent of psychiatric disorders, childhood trauma-related studies seldom consider anxiety proneness as distinct aetiological contributor.
Monet Viljoen +5 more
doaj +1 more source
Early recovery of microvascular perfusion induced by t-PA in combination with abciximab or eptifibatide during postischemic reperfusion [PDF]
, 2002 BACKGROUND: GPIIb/IIIa inhibitors abciximab and eptifibatide have been shown to inhibit platelet aggregation in ischemic heart disease. Our aim was to test the efficacy of abiciximab (Reo Pro) or eptifibatide (Integrilin) alone or in combination with ...
Bertuglia, Silva, Giusti, Andrea
core +2 more sources
Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders. [PDF]
, 2017 The complexity of the traumatic brain injury (TBI) pathology, particularly concussive injury, is a serious obstacle for diagnosis, treatment, and long-term prognosis. Here we utilize modern systems biology in a rodent model of concussive injury to gain a
Agrawal, Rahul +5 more
core +2 more sources