Results 231 to 240 of about 245,088 (289)

Immunologic Profiling Suggests an Association Between Treg Cell Dysfunction and Pain in Knee Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Pain is the hallmark symptom of osteoarthritis (OA), and its biologic drivers remain poorly understood. Although the role of innate immunity in OA has been extensively studied, the involvement of adaptive immunity, in particular Treg cells, is not well understood.
Marie Binvignat, Johanna Dubois, Maria Marco Salvador, Paul Stys, Fabien Pitoiset, Alexandra Roux, Michèle Sastre, Signe Hassler, Roberta Lorenzon, Claire Ribet, Vanessa Mhanna, Hélène Vantomme, Leslie Adda, Pierre Barennes, Nicolas Coatnoan, Kenz Le Gouge, Caroline Aheng, Alice Courties, Lise Minssen, Atul J. Butte, Adrien Six, Michelle Rosenzwajg, Nicolas Tchitchek, Francis Berenbaum, David Klatzmann, Encarnita Mariotti‐Ferrandiz, Jérémie Sellam   +26 more
wiley   +1 more source

Hematological complications in solid organ transplant recipients with telomere biology disorders: a narrative review. [PDF]

Front Immunol
Carlier FM, Planté-Bordeneuve T, Froidure A, Graux C, van Dievoet MA, van Moorsel CHM, Hoffman TW.   +6 more
europepmc   +1 more source

Linezolid‐mediated Prevention of Fibroblast Activation and Tissue Fibrosis via Mitochondrial Translation Inhibition

Arthritis &Rheumatology, EarlyView.
Objective Beyond its role as a ribosome‐targeting antibiotic, linezolid was recently shown to modulate immune responses by inhibiting mitochondrial translation. Because mitochondrial dysfunction is implicated in various fibrotic diseases, including systemic sclerosis (SSc), this study aimed to evaluate the antifibrotic potential of linezolid and ...
Xuezhi Hong, Yanhua Xiao, Haodong Qi, Shihao Zhu, Tim Filla, Andrea‐Hermina Györfi, Yi‐Nan Li, Meilin Xu, Langxian Zhi, Thuong Trinh‐Minh, Clara Dees, Georg Schett, Jörg H. W. Distler, Alexandru‐Emil Matei   +13 more
wiley   +1 more source

Tic disorders and allergic diseases: mechanistic links and the impact of allergy management - a narrative review. [PDF]

Front Allergy
Li L, Hu W, Ren Y, Zhang H, Zhu S, Zhong T, Zhang H.   +6 more
europepmc   +1 more source

Intestinal and multiple organ transplantation [PDF]

, 2000
Abu-Elmagd, K, Bueno, J, Mazariegos, G, Reyes, J, Selby, R, Starzl, TE, Todo, S   +6 more
core  

CD14 plays a critical role in pain and inflammation across multiple models of post‐traumatic osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine OA models that vary in severity of pathology and rate of progression, to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Endothelial Dysfunction: Insights into Systemic Lupus Erythematosus-associated Cardiovascular Disease and Neuropsychiatric Manifestations. [PDF]

J Cardiovasc Transl Res
Butler HM, Zehntner ME, Van Beusecum JP.
europepmc   +1 more source

Organ transplantation: A practical triumph and epistemologic collapse [PDF]

, 2003
Starzl, TE
core