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Drug Discovery Today, 2015 The choroid plexus (CP) is a highly vascularized organ located in the brain ventricles and contains a single epithelial cell layer forming the blood-cerebrospinal fluid barrier (BCSFB).
Claude Libert +1 more
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Trends in Pharmacological Sciences, 2003 Many novel anti-inflammatory compounds have been derived from research tools designed to better understand the complex process of leukocyte extravasation at sites of inflammation.
Michael P Schon
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Molecular Psychiatry, 2014 There is evidence that persistent psychiatric disorders lead to age-related disease and premature mortality. Telomere length has emerged as a promising biomarker in studies that test the hypothesis that internalizing psychiatric disorders are associated ...
Terrie E Moffitt +2 more
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Disorders of Leukocyte Chemotaxis
Pediatric Clinics of North America, 1977The rapid accumulation of inflammatory cells at sites of microbial invasion or neoplastic transformation is a central event in immunologically-mediated host defense. The availability of methodology to accurately quantify leukocyte migration in vitro has allowed the disclosure of previously unrecognized clinical disorders, namely leukocyte dysmotility ...
R, Snyderman, M C, Pike
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Disorders of Polymorphonuclear Leukocyte Function
Hospital Practice, 1985In Part II of the discussion of PMN function, the focus is on ways in which the complex biochemical processes that modulate cell motility and oxygen radical formation can go wrong. Derangements of these functions—hyperactive as well as hypoactive phagocytosis—lead to clinical disorders that predispose the host to infection and inflammatory reactions.
G J, Boxer, J T, Curnutte, L A, Boxer
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Leukocyte function and nonmalignant leukocyte disorders
Current Opinion in Pediatrics, 1993This review summarizes recent literature regarding the clinical and molecular features of nonmalignant leukocyte disorders in children. Leukocyte adhesion deficiency and chronic granulomatous disease, two inherited disorders of neutrophil function, continue to be the best-characterized disorders with respect to specific molecular defects.
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Nonmalignant Disorders of Leukocytes
DeckerMed Medicine, 2011Leukocytes, also known as white blood cells, are hematologic cells important for a host’s immune defense. They comprise several diverse cell types including lymphocytes, neutrophils, monocytes, macrophages, and eosinophils. Each plays a unique and important role in fighting infection, cancer surveillance, and maintaining immune homeostasis.
Nancy Berliner, Alison M. Schram
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Leukocyte Function in Chronic Myeloproliferative Disorders
Blood Cells, Molecules, and Diseases, 1998The myeloproliferative disorders (MPD) are clonal diseases that originate from a transformed stem cell and involve all myeloid lineage. The affected cells have both proliferative and functional impairment. Therefore, we evaluated and compared neutrophil function in 31 patients with polycythemia vera (PV), idiopathic myelofibrosis (MF), chronic myeloid ...
B, Wolach +3 more
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Leukocyte-Related Disorders: A Review for the Pediatrician
Pediatric Annals, 2020Leukocytes, or white blood cells, are part of the innate immune system that defends against infectious and foreign agents. In pediatrics, it is important to use age-specific laboratory values when interpreting results. Infections are the most common cause of leukocytosis or leukopenia in children.
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