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Nonmalignant Leukocyte Disorders
2016Abnormalities of leukocyte count are routinely encountered in medical practice and rank among the most common reasons for hematologists to be consulted. The question often begins with whether there is a primary hematologic disorder, a clonal malignancy, versus a purely reactive process where the only required therapy would be directed toward the ...
Lawrence Rice, Miho Teruya
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Leukocyte Disorders: Quantitative and Qualitative Disorders of the Neutrophil, Part 2
Pediatrics In Review, 1996The differential diagnosis for a patient presenting with recurrent infections is formidable, given the complexity of the immune system. The clinical presentation of a patient who has a qualitative neutrophil abnormality may be similar to that of one who has an antibody or complement disorder. In general, evaluation for phagocytic cell disorders (Table)
L A, Boxer, R A, Blackwood
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Leukocyte Disorders: Quantitative and Qualitative Disorders of the Neutrophil, Part 1
Pediatrics In Review, 1996Introduction Neutrophils form the first line of defense against most bacterial and fungal pathogens after disruption of the skin and mucous membranes. Once tissue is invaded by microorganisms, a variety of vasoactive and chemotactic mediators are released by the involved tissue.
L A, Boxer, R A, Blackwood
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Retinal Blood Velocity in Patients With Leukocyte Disorders
Archives of Ophthalmology, 1988The blue light entoptic phenomenon was used to measure retinal blood velocity in eight patients with chronic granulocytic leukemia, six patients with leukopenia, and matched control subjects. The retinal leukocyte velocity of the leukemic patients was 0.53 +/- 0.26 (mean +/- SD) mm/s, whereas that of the matched control subjects was 0.46 +/- 0.14 mm/s.
T, Rimmer, E M, Kohner, J M, Goldman
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Disorders of Leukocytes Leading to Recurrent Infection
Pediatric Clinics of North America, 1972Because they possess the unique property of phagocytosis, certain blood cells appear to be primarily responsible for host defense against pyogenic and fungal infection. The primary phagocyte of the peripheral blood is the polymorphonuclear neutrophil; its functions and their disorders are described in this paper.
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Deletion of leukocyte mitochondrial DNA in bipolar disorder
Journal of Affective Disorders, 1996Leukocyte mitochondrial DNA (mtDNA) was examined in 35 patients with bipolar disorder by the nested PCR method to explore whether or not the 4977 base-pair deletion (common deletion) is found. The PCR product corresponding to the common deletion was found in 2 of 35 (5.7%) patients and none of 29 normal controls.
T, Kato, Y, Takahashi
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Leukocyte telomerase activity and antidepressant efficacy in bipolar disorder
European Neuropsychopharmacology, 2014Telomeres are DNA-protein complexes that cap linear DNA strands, protecting DNA from damage. Recently, shorten telomeres length has been reported in bipolar disorder (BD) and depression. The enzyme telomerase regulates telomeres׳ length, which has been associated with cellular viability; however it is not clear how telomerase may be involved in the ...
Marcio Gerhardt, Soeiro-de-Souza +9 more
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Physiological Roles of Leukocytes and Disorders
2018This chapter describes white blood cells of the peripheral blood: neutrophils, eosinophils, basophils, monocytes, and lymphocyte subsets. It describes their basic physiology and important disease states associated with defects of each of these entities. Each of these cells arises from a common bone marrow myeloid or lymphoid progenitor to differentiate
Jahnavi Gollamudi +2 more
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Cyclic-AMP production by polymorphonuclear leukocytes in psychiatric disorders
Biological Psychiatry, 1989The cyclic adenosine monophosphate (cAMP) responses to histamine, prostaglandin-E1, and isoproterenol in polymorphonuclear leukocytes from drug-free normal controls and patients with schizophrenia or major depressive disorder were compared. These three groups of subjects did not differ in their cAMP responses to receptor activation.
P D, Kanof +5 more
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Human Leukocyte Antigen Type and Posttransplant Lymphoproliferative Disorder
Transplantation, 2015Posttransplant lymphoproliferative disorder (PTLD) is an infrequent but serious complication of solid organ transplantation. Early detection and initiation of therapy may improve outcomes. The purpose of this study was to identify human leukocyte antigen (HLA) type as risk and prognostic factors for PTLD.A review was undertaken to identify PTLD cases ...
Mark E, Lustberg +7 more
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