Results 181 to 190 of about 256,119 (304)

Senolytics Reverse PM_2.5 - Induced Cell and Vascular Dysfunction. [PDF]

Cardiovasc Toxicol
Gomes D, McFall SA, Chen N, Zhao J, Srivastava S, Conklin DJ, O'Toole TE.   +6 more
europepmc   +1 more source

Mapping Allergen B‐ and T‐Cell Epitopes: Technological Advances and Their Role in Precision Allergy Therapy

Allergy, EarlyView.
ABSTRACT Allergic diseases arise from aberrant immune recognition of otherwise harmless environmental proteins and are driven by epitope‐specific interactions between allergens and the adaptive immune system. Although component‐resolved diagnostics have improved molecular characterisation of sensitization, they remain limited to whole‐allergen ...
Mark Møiniche, Josefine Corneliussen, Kristoffer H. Johansen, Alexandre Ruiz‐Carrasco, Caroline Paulsen, Yuchen Li, Carolina Barra, Sandhya Bangaru, Monica L. Fernández‐Quintero, Ewa Bartko, Lars Blom, Esperanza Rivera‐de‐Torre   +11 more
wiley   +1 more source

HIV transgenic mouse monocytes display increased <i>in vivo</i> migration across the blood-brain barrier associated with increased expression of genes associated with mononuclear leukocyte movement. [PDF]

J Virol
Sydenstricker A, Lee D, Voss A, Zheng JH, Hur H, Kandpal M, Goldstein H.   +6 more
europepmc   +1 more source

The Anti‐Inflammatory Effect of Normothermic Machine Perfused Human Kidneys on Monocyte‐Derived Dendritic Cells

Artificial Organs, EarlyView.
The immunogenicity of donor kidneys on NMP can be studied using monocyte‐derived dendritic cells. Incubation with perfusate showed an anti‐inflammatory dendritic cell phenotype and function that suggests the release of an anti‐inflammatory factor or factors during NMP. ABSTRACT Background The immunomodulatory activity of normothermic machine perfusion (
Laura W. D. Knijff, Asel S. Arykbaeva, Sandra W. van der Kooij, Dorottya K. de Vries, Mieke F. van Essen, Ian P. J. Alwayn, Henri G. D. Leuvenink, Rutger J. Ploeg, Cees van Kooten   +8 more
wiley   +1 more source

Macrophage modulation accounts for the anti-inflammatory effect of Hypnea cervicornis agglutinin in rat arthritis induced by zymosan. [PDF]

Glycoconj J
da Silva Nascimento FG, de Souza Ferreira Bringel PH, de Araujo DF, Mota MRL, de Queiroz Martins MG, da Silva MTL, Nobre CAS, Cavada BS, do Nascimento KS, Castro RR, Assreuy AMS.   +10 more
europepmc   +1 more source

Prospective phase I study of nivolumab to promote graft‐versus‐tumour in relapsed or refractory haematological malignancy post allogeneic haematopoietic stem cell transplantation

British Journal of Haematology, EarlyView.
Baseline immunophenotype and gene expression predict suitability for salvage nivolumab in patients with relapsed/refractory haematological malignancy. Summary Allogeneic haematopoietic stem cell transplantation (alloHSCT) relies on donor‐derived T cells to mediate the graft‐versus‐tumour (GVT) effect, but relapse may result from impaired immune ...
Trung Q. Ngo, Eric Wong, Joanne E. Davis, Mandy Ludford‐Menting, Jessica Klass, Sara K. Dohrmann, Rachel Koldej, David Ritchie   +7 more
wiley   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Jejunal mucosal immune response in goats ten months after <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> challenge is primarily determined by lesion severity rather than vaccination route. [PDF]

Vet Q
Criado M, Silva M, Mendívil P, Zapico D, Pérez-Rojo V, Benavides J, Espinosa J, Elguezabal N, Gutiérrez-Expósito D.   +8 more
europepmc   +1 more source

Targeted delivery of the CB2 receptor agonist JWH‐133 via VCAM‐1‐functionalised nanoparticles attenuates atherosclerosis and reveals sex‐specific therapeutic outcomes

British Journal of Pharmacology, EarlyView.
Background and Purpose Atherosclerosis, a chronic inflammatory disease characterised by lipid accumulation and endothelial dysfunction, remains a leading cause of cardiovascular morbidity and mortality. While cannabinoid 2 (CB2) receptor agonists show therapeutic promise in preclinical studies, their systemic application is hindered by poor ...
Lucía Martín‐Navarro, Lucía Martín‐Banderas, Josefa Álvarez‐Fuentes, María Dolores Herrera‐González   +3 more
wiley   +1 more source

The P2X7 receptor: insights from the murine monoclonal antibody clone L4. [PDF]

Purinergic Signal
Sluyter R, Elhage A, Bartlett R, Watson D, Stokes L, Skarratt KK, Fuller SJ, Gu BJ.   +7 more
europepmc   +1 more source