Results 41 to 50 of about 256,119 (304)

Detection of angiotensin II in supernatants of stimulated mononuclear leukocytes by matrix-assisted laser desorption ionization time-of-flight/time-of-flight mass analysis [PDF]

, 2005
Angiotensin II ( Ang II) is the major vasoactive component of the renin- angiotensin system. Several components of the renin- angiotensin system have been demonstrated in different tissues.
TOLLE, M, GOBOM, J, Vanholder, R., Giebing, G, KARADOGAN, S, SCHLUTER, H, Jankowski, V, HENNING, L, Schönfelder, G., Krakow, A., van der Giet, M., Vanholder, R, Gustavsson, Niklas, Karadogan, S., Webb, J., JANKOWSKI, J, Jankowski, Vera, Tölle, M., Schlüter, H., Vanholder, Raymond, ZIDEK, W, Gustavsson, Niklas,, SCHONFELDER, G, Henning, L., Gustavsson, N., KRAKOW, A, GUSTAVSSON, N, Zidek, W., Gobom, J., HILGERS, KF, Lehrach, H., Hilgers, K., WEBB, J, GIEBING, N, Jankowski, V., Lund University., Giebing, G., VAN DER GIET, M, LEHRACH, H   +38 more
core   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Characterization of aldosterone binding sites in circulating human mononuclear leukocytes.

, 1985
Aldosterone binding sites in human mononuclear leukocytes were characterized after separation of cells from blood by a Percoll gradient. After washing and resuspension in RPMI-1640 medium, cells were incubated at 37 degrees C for 1 h with different ...
WEBER P.C., ARMANINI, DECIO, STRASSER T, T. Strasser, P. C. Weber, D. Armanini   +5 more
core   +2 more sources

Polyomaviruses BK and JC DNA infection in peripheral blood cells from blood donors

Brazilian Journal of Infectious Diseases, 2019
Objectives: To investigate the prevalence of human polyomavirus (BK and JC viruses) infection in peripheral blood mononuclear cells of healthy blood donors. Methods: The study included 250 healthy blood donors.
Malihe Fathi Haghighi, Noorossadat Seyyedi, Ali Farhadi, Farahnaz Zare, Leila Kasraian, Gholam Reza Refiei Dehbidi, Reza Ranjbaran, Abbas Behzad-Behbahani   +7 more
doaj   +1 more source

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

Aggregation of mononuclear and red blood cells through an α4β1-Lu/basal cell adhesion molecule interaction in sickle cell disease

Haematologica, 2010
Background Abnormal interactions between red blood cells, leukocytes and endothelial cells play a critical role in the occurrence of the painful vaso-occlusive crises associated with sickle cell disease.
Vicky Chaar, Julien Picot, Olivier Renaud, Pablo Bartolucci, Ruben Nzouakou, Dora Bachir, Frédéric Galactéros, Yves Colin, Caroline Le Van Kim, Wassim El Nemer   +9 more
doaj   +1 more source

Mitochondrial redox impairment and enhanced autophagy in peripheral blood mononuclear cells from type 1 diabetic patients

Redox Biology, 2022
Type 1 diabetes (T1D) involves critical metabolic disturbances that contribute to an increased cardiovascular risk. Leukocytes are key players in the onset of atherosclerosis due to their interaction with the endothelium.
F. Canet, P. Díaz-Pozo, C. Luna-Marco, M. Fernandez-Reyes, T. Vezza, M. Marti, J.D. Salazar, I. Roldan, C. Morillas, S. Rovira-Llopis, M. Rocha, V.M. Víctor   +11 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

IMMUNOLOGICAL AND METABOLIC FACTORS INTERACTION IN THE DEVELOPMENT AND PROGRESSION OF MICROVASCULAR COMPLICATIONS IN LATENT AUTOIMMUNE DIABETES OF ADULTS (LADA)

Бюллетень сибирской медицины, 2014
Some researchers found that the development of microvascular complications (nephropathy, retinopathy) with latent autoimmune diabetes adults (LADA) occurs much earlier than in type 1 diabetes mellitus.
T. V. Saprina, T. S. Prokhorenko, F. E. Lazarenko, I. N. Vorozhtsova, N. V. Ryazantseva   +4 more
doaj   +1 more source