Results 101 to 110 of about 242,416 (306)

The Cytotoxic Effects of Sio2 Nanoparticles on Human Blood Mononuclear Cells

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2012
Introduction: Regarding the increasing use of silicon dioxide nanoparticles in medical biotechnology and probable side effects and diseases resulting from its usage, this study was performed to assess the toxic effects of different concentrations of SiO2
A Jebali, H Hekmatimoghaddam, s Barzegar, H Fallahzadeh, A Barkhordari   +4 more
doaj  

Low-Density-Lipoprotein Receptor and 3-Hydroxy-3-Methylglutaryl Coenzyme-A Reductase Gene-Expression in Human Mononuclear Leukocytes Is Regulated Coordinately and Parallels Gene-Expression in Human Liver

, 1994
The liver plays a key regulatory role in cholesterol metabolism. Two proteins are central in this role; the LDL receptor and 3-hydroxy-3-methylglutaryl CoA reductase (HMG CoA reductase), the rate-limiting enzyme in cholesterol biosynthesis.
Powell, EE, P A Kroon, E E Powell, Kroon, PA   +3 more
core   +1 more source

Bovine colostrum and immune function after exercise [PDF]

, 2012
Strenuous and/or prolonged exercise causes transient perturbations in immune function. It is well accepted that this is one mechanism contributing to the higher occurrence of infection (e.g.
Glen Davison, Davison, Glen
core   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

The role of Th1/Th2 disbalanced immune response in the determination of clinical features of autoimmune diabetes mellitus

Сахарный диабет, 2011
Aim. To elucidate the role of Th1/Th2 polarization of immune response in LADA patients in the realization of the clinical phenotype of the disease. Materials and methods. 70 patients aged 21-61 (mean 41.3?1.0 yr) with DM diagnosed based on WHO criteria
Tatiana Vladimirovna Saprina, F E Lazarenko, T S Prokhorenko, N V Ryazantseva, Irina Nikolaevna Vorozhtsova   +4 more
doaj   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Androgen binding sites in peripheral human mononuclear leukocytes of healthy males and females.

, 1994
Androgen binding sites have been identified in circulating human mononuclear leukocytes of healthy donors of both sexes. Cells were separated from blood samples on a Ficoll gradient and incubated with different concentrations of [3H]testosterone in the ...
BAUR S., ARMANINI, DECIO, MEURER M, LINDL U, KELLER U, KUHNLE U   +5 more
core   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

TGF-b2 induction regulates invasiveness of theileria-transformed leukocytes and disease susceptibility [PDF]

, 2010
Theileria parasites invade and transform bovine leukocytes causing either East Coast fever (T. parva), or tropical theileriosis (T. annulata). Susceptible animals usually die within weeks of infection, but indigenous infected cattle show markedly reduced
Regina Lizundia, Baumgartner, M, Lizundia, Regina, Janski, N., Glasgow, Weri, W, Werling, D, Bern, Switzerland, Werling, Dirk, Weitzmn, J B, Werling, D., Marie Chaussepied, Glass, Elizabeth, Glass Elizabeth J., Shiels, Brian R., Langsley, G, CNRS UM7216, Paris, Weir, W., Jensen, K., Langsley Gordon, Jensen, K, Jonathan B Weitzman, Weitzman, Jonathan, Chaussepied, Marie, Lizundia, R, Weitzman, Jonathan B., Shiels, Brian, Jensen, Kirsty, Gordon Langsley, Royal (Dick) School of Veterinary Studies, Elizabeth J. Glass, Janski, N, Dirk Werling, Paris-Descartes, Brian R Shiels, Natacha Janski, Jensen Kirsty, Janski, Natacha, Baumgartner, M., Chaussepied, M, Baumgartner, Martin, Langsley, G., Chaussepied, M., Glass, Elizabeth J., Martin Baumgartner, Janski Natacha, Weitzman Jonathan B., Weitzman, J.B., Jonathan B. Weitzman, Shiels, B.R., Shiels, B R, Werling Dirk, Edinburgh, Glass, E.J., Heussler, V.T., Paris-Diderot, Chaussepied Marie, Inserm, Paris, Elizabeth J Glass, Baumgartner Martin, Brian R. Shiels, Glass, E J, Lizundia Regina, Langsley, Gordon, Lizundia, R., Weir, William, Kirsty Jensen, Shiels Brian R., Weir William, William Weir   +69 more
core   +2 more sources