Results 31 to 40 of about 242,416 (306)

Immunological response of human leucocytes after exposure to lipopolysaccharides from Porphyromonas gingivalis

Clinical and Experimental Dental Research, 2021
Porphyromonas gingivalis (P. gingivalis) is a gram‐negative bacterium and an important etiologic agent of periodontitis. P. gingivalis releases outer membrane vesicles containing lipopolysaccharides (LPS), which can penetrate periodontal tissues. Once in
Sara Alizadehgharib, Anna‐Karin Östberg, Agnes Dahlstrand Rudin, Ulf Dahlgren, Karin Christenson   +4 more
doaj   +1 more source

Down-regulation of cholesterol biosynthesis in sitosterolemia: diminished activities of acetoacetyl-CoA thiolase, 3-hydroxy-3-methylglutaryl-CoA synthase, reductase, squalene synthase, and 7-dehydrocholesterol Δ7-reductase in liver and mononuclear leukocytes

Journal of Lipid Research, 1998
Sitosterolemia is a recessively inherited disorder characterized by abnormally increased plasma and tissue plant sterol concentrations. Patients have markedly reduced whole body cholesterol biosynthesis associated with suppressed hepatic, ileal, and ...
Akira Honda, Gerald Salen, Lien B. Nguyen, G. Stephen Tint, Ashok K. Batta, Sarah Shefer   +5 more
doaj   +1 more source

An Altered Metabolism in Leukocytes Showing in vitro igG Memory From SARS-CoV-2-Infected Patients

Frontiers in Molecular Biosciences, 2022
Coronavirus disease 2019 (COVID 19) is a systemic infection that exerts a significant impact on cell metabolism. In this study we performed metabolomic profiling of 41 in vitro cultures of peripheral blood mononuclear cells (PBMC), 17 of which displayed ...
G. Fanelli, F. Gevi, G. Zarletti, M. Tiberi, V. De Molfetta, G. Scapigliati, A. M. Timperio   +6 more
doaj   +1 more source

Bone Marrow and Peripheral Blood Mononuclear Cell Phenotype Changes after Cultivation and Autologous Infusion in Patients with Primary Biliary Cholangitis [PDF]

Iranian Journal of Medical Sciences
Background: Primary biliary cholangitis (PBC) is a condition affecting the liver and immune system. In this study, the impact of autologous bone marrow-derived mononuclear cell (BM-MNC) transplantation on PBC patients was investigated.
Dana Saipiyeva, Manarbek Askarov, Nazanin Jafari, Rano Zhankina, Paul R. Heath, Larissa Kozina, Alyona Boltanova, Ardak Omarbekov, Nurbek Ilyassov, Turlybek Tuganbekov, Nadiar M. Mussin, Asset A. Kaliyev, Yerlan Sultangereyev, Farhad Rahmanifar, Mahdi Mahdipour, Shabnam Bakhshalizadeh, Reza Shirazi, Nader Tanideh, Amin Tamadon   +18 more
doaj   +1 more source

Characterization of aldosterone binding sites in circulating human mononuclear leukocytes.

, 1985
Aldosterone binding sites in human mononuclear leukocytes were characterized after separation of cells from blood by a Percoll gradient. After washing and resuspension in RPMI-1640 medium, cells were incubated at 37 degrees C for 1 h with different ...
WEBER P.C., ARMANINI, DECIO, STRASSER T
core   +2 more sources

Infrared spectroscopic analysis of mononuclear leukocytes in peripheral blood from Alzheimer's disease patients

, 2012
Peripheral mononuclear leukocytes from Alzheimer's disease (AD) patients were analyzed by infrared spectroscopy and their spectroscopic properties were compared with those from age-matched healthy controls.
Calero Lara, Miguel, Álvarez-Vicente, María Isabel, Martínez-Martín, Pablo, Molina Santos, Marina Mercedes, Molina, Marina, Toledano, Adolfo, Carmona, Pedro, Toledano Gasca, Adolfo, Martínez Martín, Pablo, Bermejo Pareja, Félix, Alvarez, Isabel   +10 more
core   +1 more source

Cryopreservation of Human Mucosal Leukocytes. [PDF]

PLoS ONE, 2016
BACKGROUND:Understanding how leukocytes in the cervicovaginal and colorectal mucosae respond to pathogens, and how medical interventions affect these responses, is important for developing better tools to prevent HIV and other sexually transmitted ...
Sean M Hughes, Zhiquan Shu, Claire N Levy, April L Ferre, Heather Hartig, Cifeng Fang, Gretchen Lentz, Michael Fialkow, Anna C Kirby, Kristina M Adams Waldorf, Ronald S Veazey, Anja Germann, Hagen von Briesen, M Juliana McElrath, Charlene S Dezzutti, Elizabeth Sinclair, Chris A R Baker, Barbara L Shacklett, Dayong Gao, Florian Hladik   +19 more
doaj   +1 more source

Increased Expression of Cell-Cell Signaling Genes by Stimulated Mononuclear Leukocytes in Patients with Previous Atherothrombotic Stroke A Whole Genome Expression Profile Study [PDF]

, 2009
Background/Aims: Inflammation plays an important role in atherosclerosis and stroke. Acute infections are recognized as trigger factors for ischemic stroke. Methods: In this whole genome expression profile study of 15 patients and 15 control subjects, we
Wiest, Tina, Horstmann, Solveig, Honold, Cornelius, Hergenhahn, Manfred, Mansmann, Ulrich, Wagner, Simone, Weninger, Annette, Pfleger, Karin, Grond-Ginsbach, Caspar, Hollstein, Monika, Grau, Armin J., Hummel, Manuela, Knyazev, Yuri   +12 more
core   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source