Results 71 to 80 of about 256,119 (304)

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Macrocyclic lactone anthelmintic-induced leukocyte binding to Dirofilaria immitis microfilariae: Influence of the drug resistance status of the parasite

International Journal for Parasitology: Drugs and Drug Resistance, 2019
The macrocyclic lactone anthelmintics are the only class of drug currently used to prevent heartworm disease. Their extremely high potency in vivo is not mirrored by their activity against Dirofilaria immitis larvae in vitro, leading to suggestions that ...
Tessa Berrafato, Ruby Coates, Barbara J. Reaves, Daniel Kulke, Adrian J. Wolstenholme   +4 more
doaj   +1 more source

Multiple effects of dipyridamole on neutrophils and mononuclear leukocytes: adenosine-dependent and adenosine-independent mechanisms

, 1991
Dipyridamole is an antithrombotic drug that has been shown to influence not only platelet function but also some aspects of leukocyte activation.
S. Colli, E. Tremoli
core   +1 more source

Decreased levels of B-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction

, 1998
Lymphocytes can be activated to produce and release opioid peptides. We investigated the levels of immunoreactive β-endorphin in peripheral blood mononuclear cells from 11 patients with acute myocardial infarction.
A.E. PANERAI, C. PECHLANER, M. JOANNIDIS, C. J. WIEDERMANN, T. BURATTI, P. SACERDOTE, S. E. MANFREDA, S. DUNZENDORFER, P. SHRATZENBERGER   +8 more
core   +1 more source

Immunological profiles of Bos taurus and Bos indicus cattle infested with the cattle tick, Rhipicephalus (Boophilus) microplus [PDF]

, 2009
The cattle tick, Rhipicephalus (Boophilus) microplus, is a major threat to the improvement of cattle production in tropical and subtropical countries worldwide.
Emily K. Piper, Bos Taurusimmunological Profiles Of, Jonsson, N., Piper, Emily K., Jackson, L.A., Vance, M., Paula Moolhuijzen, Piper, E., Gondro, C., Ala E. Lew-tabor, Louise A. Jackson, Lew-Tabor, Ala E., Vance, M.E., Ala E, Cedric Gondro, Lew-Tabor, A.E., Vance, Megan E., Nicholas N. Jonsson, Lew-Tabor, A., Moolhuijzen, Paula, Megan E. Vance, Lew-Tabor, A. ., Moolhuijzen, P., Jonsson, N.N., A. Jackson, Jackson, L., Jonsson, Nicholas N., Gondro, Cedric, Piper, E.K., Jackson, Louise A., Department of Agriculture and Fisheries, Queensland   +30 more
core   +2 more sources

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

ZINC CONCENTRATION IN LEUKOCYTES : MONONUCLEAR CELLS, GRANULOCYTES, T-LYMPHOCYTES, NON-T LYMPHOCYTES AND MONOCYTES [PDF]

, 1981
This study was designed to evaluate the zinc concentrations of leukocytes: monon- uclear cells, granulocytes, T and non-T lymphocytes and monocytes.　　The zinc content of leukocytes was 0.137 ±0.040 μg/10⁷ cells.
Sakano, Takashi, Hatano, Shuichi, Nishi, Yoshikazu, Horino, Nobuko, Usui, Tomofusa   +4 more
core  

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants

Advanced Science, EarlyView.
A bioactive poly(citrate‐polyglycol‐procyanidin) (PCGP) nanoshield is developed for cardiovascular implants to restore endothelial mitochondrial homeostasis following vascular injury. By preserving mitochondrial integrity, re‐establishing metabolic balance, and activating PI3K/Akt/eNOS‐NO signaling, the PCGP interface promotes functional endothelial ...
Xiyu Liu, Wen Zhang, Lunxin Liu, Lan Gui, Yumei Qin, Xiaohui Yang, Longjian Zhang, Chaohua Wang, Jinpeng Hu, Gaoyang Guo, Qing Jiang, Jin Wang, Li Yang, Bo Zhang, Yunbing Wang   +14 more
wiley   +1 more source

Expression of FcμR by bovine mononuclear blood leukocytes

Developmental & Comparative Immunology
The receptor for IgM has been identified a few years ago, but its expression by bovine mononuclear cells has not yet been studied. We used rabbit antibodies against bovine FcμR to begin to fill this gap. Anti-FcμR antibodies bound to B lymphocytes and monocytes, although less than to neutrophils.
Gilbert, Florence, Martins, Rodrigo Prado, Rainard, Pascal   +2 more
openaire   +4 more sources