Results 101 to 110 of about 221,944 (307)

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

ROLE OF ENDOCANNABINOID RECEPTORS IN IMMUNE RESPONSE REGULATION

Медицинская иммунология, 2014
. Expression of endocannabinoid receptors (СВ1, СВ2) in immunocompetent cells was studied under the conditions of in vivo stimulation of immune system. Intracorporeal blood irradiation and enrichment of peripheral blood by ozone/oxygen mixture were used ...
E. G. Lobanova
doaj   +1 more source

Mineralocorticoid effector mechanism of liquorice derivatives in human mononuclear leukocytes.

, 1989
The mineralocorticoid effector mechanism of glycyrrhetinic acid and of its ester derivative carbenoxolone was evaluated in human mononuclear leukocytes by radioreceptorassay and measurement of intracellular sodium and potassium after incubation of the ...
WEHLING M, WEBER PC, ARMANINI, DECIO
core  

Mononuclear Leukocyte Cyclic Adenosine Monophosphate Responses in Psoriasis Are Normal [PDF]

, 1984
It has been proposed that immune dysfunction in psoriasis is a consequence of aberrent cyclic nucleotide metabolism. We have examined cyclic AMP responses to isoprenaline, histamine, and prostaglandin E2 in peripheral blood mononuclear leukocytes from ...
Macdonald, D.M., Hanson, Jennifer M, Morley, J., Archer, C B   +3 more
core   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Molecular mechanisms of regulatory action of heat shock protein 27 kDa in the apoptosis of tumor cells

Бюллетень сибирской медицины, 2011
Score mRNA expression and the level of Hsp27 (Heat shock protein 27) and phospho-Hsp27 in tumor cell line Jurkat and THP-1, as well as in mononuclear leukocytes obtained from healthy donors was investigated.
Ye. V. Kaigorodova
doaj   +1 more source

Flowcytometric Analysis of Tumor Associated Macrophages in Invasive Ductal Carcinoma of Breast [PDF]

Background: Invasive ductal carcinoma is the most common type of breast cancer in Iran. Impaired immune responses occur frequently in cancer patients, but the mechanisms of the induced immune defects remain poorly understood.
حسن, زهیر محمد, روانگرد, فاطمه, فرازمند, سوسن, امانی, داور, کریم زاده, مجتبی   +4 more
core  

Modification of platelet aggregation by leukocytes in acute ischemic stroke.

, 1994
Platelet aggregation plays an important role in the pathogenesis of thromboembolic cerebrovascular disease. Leukocytes can efficiently stimulate as well as inhibit platelet aggregability.
R Sigmund, W Hacke, A J Grau
core   +1 more source

TGF-b2 induction regulates invasiveness of theileria-transformed leukocytes and disease susceptibility [PDF]

, 2010
Theileria parasites invade and transform bovine leukocytes causing either East Coast fever (T. parva), or tropical theileriosis (T. annulata). Susceptible animals usually die within weeks of infection, but indigenous infected cattle show markedly reduced
Regina Lizundia, Baumgartner, M, Lizundia, Regina, Janski, N., Glasgow, Weri, W, Werling, D, Bern, Switzerland, Werling, Dirk, Weitzmn, J B, Werling, D., Marie Chaussepied, Glass, Elizabeth, Glass Elizabeth J., Shiels, Brian R., Langsley, G, CNRS UM7216, Paris, Weir, W., Jensen, K., Langsley Gordon, Jensen, K, Jonathan B Weitzman, Weitzman, Jonathan, Chaussepied, Marie, Lizundia, R, Weitzman, Jonathan B., Shiels, Brian, Jensen, Kirsty, Gordon Langsley, Royal (Dick) School of Veterinary Studies, Elizabeth J. Glass, Janski, N, Dirk Werling, Paris-Descartes, Brian R Shiels, Natacha Janski, Jensen Kirsty, Janski, Natacha, Baumgartner, M., Chaussepied, M, Baumgartner, Martin, Langsley, G., Chaussepied, M., Glass, Elizabeth J., Martin Baumgartner, Janski Natacha, Weitzman Jonathan B., Weitzman, J.B., Jonathan B. Weitzman, Shiels, B.R., Shiels, B R, Werling Dirk, Edinburgh, Glass, E.J., Heussler, V.T., Paris-Diderot, Chaussepied Marie, Inserm, Paris, Elizabeth J Glass, Baumgartner Martin, Brian R. Shiels, Glass, E J, Lizundia Regina, Langsley, Gordon, Lizundia, R., Weir, William, Kirsty Jensen, Shiels Brian R., Weir William, William Weir   +69 more
core   +2 more sources

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source