Results 81 to 90 of about 221,944 (307)

1,25-dihydroxyvitamin D3 and development of tuberculosis in cattle [PDF]

, 2003
This report describes the presence and activity of 1,25-dihydroxyvitamin D3 (1,25-D3) in experimental bovine tuberculosis. Animals that went on to develop tuberculous lesions exhibited a rapid transient increase in serum 1,25-D3 within the first 2 weeks ...
Hewinson, R. G., Vordermeier, H.M., Rhodes, S. G., Terry, L.A., Hope, Jayne; id_orcid   +4 more
core  

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

In Vitro Generation of Procoagulant Activity by Corynebacterium parvum-Stimulated Mononuclear Leukocytes

, 1985
Thromboembolic complications are known in cancer patients after i.v. administration of Corynebacterium parvum. We examined the ability of this organism to induce production of procoagulant activity by human blood mononuclear leukocytes in vitro.
G Ricci, D Fumarola, G Miragliotta, G Barone, C Marcuccio   +4 more
core   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Decreased levels of B-endorphin in circulating mononuclear leukocytes from patients with acute myocardial infarction

, 1998
Lymphocytes can be activated to produce and release opioid peptides. We investigated the levels of immunoreactive β-endorphin in peripheral blood mononuclear cells from 11 patients with acute myocardial infarction.
A.E. PANERAI, C. PECHLANER, M. JOANNIDIS, C. J. WIEDERMANN, T. BURATTI, P. SACERDOTE, S. E. MANFREDA, S. DUNZENDORFER, P. SHRATZENBERGER   +8 more
core   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Some hematological characteristics of adenomyosis

Гинекология, 2013
In the given work are presented some hematological criteria of diagnostics of adenomyosis, is also explored opportunities to use the results of studies of the population composition of blood leukocytes and its relationship poly - and mononuclear cells in
M R Orazov
doaj  

Expression of FcμR by bovine mononuclear blood leukocytes

Developmental & Comparative Immunology
The receptor for IgM has been identified a few years ago, but its expression by bovine mononuclear cells has not yet been studied. We used rabbit antibodies against bovine FcμR to begin to fill this gap. Anti-FcμR antibodies bound to B lymphocytes and monocytes, although less than to neutrophils.
Gilbert, Florence, Martins, Rodrigo Prado, Rainard, Pascal   +2 more
openaire   +4 more sources

Immunological profiles of Bos taurus and Bos indicus cattle infested with the cattle tick, Rhipicephalus (Boophilus) microplus [PDF]

, 2009
The cattle tick, Rhipicephalus (Boophilus) microplus, is a major threat to the improvement of cattle production in tropical and subtropical countries worldwide.
Emily K. Piper, Bos Taurusimmunological Profiles Of, Jackson, Louise A, Jonsson, N., Piper, Emily K., Jackson, L.A., Vance, M., Lew-Tabor, Ala E, Vance, Megan E, Paula Moolhuijzen, Piper, E., Gondro, C., Ala E. Lew-tabor, Louise A. Jackson, Lew-Tabor, Ala E., Vance, M.E., Ala E, Jonsson, Nicholas N, Cedric Gondro, Piper, Emily K, Lew-Tabor, A.E., Vance, Megan E., Nicholas N. Jonsson, Lew-Tabor, A., Moolhuijzen, Paula, Megan E. Vance, Lew-Tabor, A. ., Moolhuijzen, P., Jonsson, N.N., A. Jackson, Jackson, L., Jonsson, Nicholas N., Gondro, Cedric, Piper, E.K., Jackson, Louise A.   +34 more
core   +2 more sources

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source