Results 71 to 80 of about 221,944 (307)

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

Andrographolide Inhibits Expression of NLPR3 Inflammasome in Canine Mononuclear Leukocytes

Animals
Inflammasomes are multiprotein complexes that trigger processes through caspase-1 activation, leading to the maturation of proinflammatory cytokines, such as IL-1β and IL-18.
Alejandro Albornoz, Bibiana Pardo, Sofia Apaoblaza, Claudio Henriquez, Javier Ojeda, Benjamín Uberti, Juan Hancke, Rafael A. Burgos, Gabriel Moran   +8 more
doaj   +1 more source

In vitro cholesterol synthesis in freshly isolated mononuclear cells of human blood: effect of in vivo administration of clofibrate and/or cholestyramine.

Journal of Lipid Research, 1980
The rate of incorporation of [2-14C]acetate into cholesterol has been measured in freshly isolated peripheral blood mononuclear leukocytes from patients on various hypolipidemic drugs that affect whole body cholesterol synthesis.
D J McNamara, N O Davidson, S Fernandez
doaj   +1 more source

Chitotriosidase activity in plasma and mononuclear and polymorphonuclear leukocyte populations [PDF]

Journal of Clinical Laboratory Analysis, 2003
AbstractIn the general population, about 5% of individuals are homozygotic and 35% are heterozygotic carriers for chitotriosidase (ChT) deficiency. Activated macrophages are considered to be the main source of plasma ChT activity, which permits the biochemical characterization of homozygote deficients.
Lorena, Bouzas, J, Carlos Guinarte, J, Carlos Tutor   +2 more
openaire   +2 more sources

Monoclonal antibody identification of infiltrating mononuclear leukocytes in lupus nephritis [PDF]

, 1986
Monoclonal antibody identification of infiltrating mononuclear leukocytes in lupus nephritis (LN). Populations of mononuclear inflammatory cells infiltrating the renal interstitium in LN were studied by means of an avidin–biotin immunoperoxidase ...
Knowles, Daniel M., D'Agati, Vivette D., Appel, Gerald B., Estes, Dorothy, Pirani, Conrad L.   +4 more
core   +1 more source

Engineering Human Donor Derived Germinal Center‐Like Organoids (GCLOs) for Studying Immune Response to Vaccination

Advanced Science, EarlyView.
We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar, Carlos Gomez, Giancarlo Asencio, Suresh Pallikkuth, Ashutosh Agarwal   +4 more
wiley   +1 more source

Macrocyclic lactone anthelmintic-induced leukocyte binding to Dirofilaria immitis microfilariae: Influence of the drug resistance status of the parasite

International Journal for Parasitology: Drugs and Drug Resistance, 2019
The macrocyclic lactone anthelmintics are the only class of drug currently used to prevent heartworm disease. Their extremely high potency in vivo is not mirrored by their activity against Dirofilaria immitis larvae in vitro, leading to suggestions that ...
Tessa Berrafato, Ruby Coates, Barbara J. Reaves, Daniel Kulke, Adrian J. Wolstenholme   +4 more
doaj   +1 more source

Bradykinin-inactivating activity of mononuclear leukocytes.

Ensho, 1986
Bradykinin-inactivating activity of mononuclear leukocytes was examined using guinea-pig macrophages and lymphocytes. Intact macrophages rapidly inactivated bradykinin. Bradykinin-inactivating activity of macrophages was present in the membrane and cytosol fractions but not in the nuclear and granular fractions.
Nagaoka, Isao, Yamashita, Tatsuhisa, Yasuura, Shinichi   +2 more
openaire   +2 more sources

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Multiple effects of dipyridamole on neutrophils and mononuclear leukocytes: adenosine-dependent and adenosine-independent mechanisms

, 1991
Dipyridamole is an antithrombotic drug that has been shown to influence not only platelet function but also some aspects of leukocyte activation.
S. Colli, E. Tremoli
core   +1 more source