Results 141 to 150 of about 80,122 (309)

A Non‐Antigenic Randomized Polyethylene Glycol/Poly(2‐Phenyl‐2‐Oxazine)‐Based Drug Delivery Platform

Macromolecular Rapid Communications, EarlyView.
Randomized PEG (rPEG), a conceptually new PEG alternative, is combined with poly(2‐phenyl‐2‐oxazine) (PPheOzi) to establish an rPEG‐b‐PPheOzi‐b‐rPEG micellar drug delivery platform. The PPheOzi block enables high drug loadings, while competitive ELISA reveals a drastic reduction in anti‐PEG antibody affinity of rPEG in comparison to PEG.
Julian Schmidt, Anna‐Lena Ziegler, Florian T. Kaps, Laura J. Rosenberger, Matthias Bros, Holger Frey, Robert Luxenhofer   +6 more
wiley   +1 more source

CLEC14A correlates with neutrophil infiltration in hepatocellular carcinoma and mediates neutrophil recruitment across liver endothelial cells

The Journal of Pathology, EarlyView.
Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related deaths globally, and cases are predicted to rise dramatically over the next few years. Overcoming the immune microenvironment in HCC remains a challenge, and innate immune populations such as tumour‐associated neutrophils can potentially impair the success of immunotherapy ...
Joanne M O'Rourke, Dean Kavanagh, Ayla O'Keeffe, Kylie Savoye, Kaiyi Yang, Daniel A Patten, Catherine E Willoughby, Josep M Llovet, Georgiana Neag, Helen L Reeves, Peter W Hewett, Neena Kalia, Tahir Shah, Yuk Ting Ma, Kelly Hunter, Joe Flint, Jack L McMurray, Owen Cain, Fabian Spill, Derek A Mann, Amy J Naylor, Victoria Heath, Christopher J Weston, Roy Bicknell, Shishir Shetty   +24 more
wiley   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Type I interferon overactivation in sera of patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease

Rheumatology &Autoimmunity, EarlyView.
Sera from patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease (ILD) exhibit significantly higher type I interferon (IFN‐I) bioactivity and interferon‐stimulated gene‐inducing activity compared to anti‐ARS‐positive ILD and healthy controls.
Shohei Nakamura, Yasuhiro Katsumata, Yuko Okamoto, Masayoshi Harigai   +3 more
wiley   +1 more source

Functional Repurposing of Magnetic Nanoparticle‐Assisted Hyperthermia for Immune Cell Labelling and Tracking

Small Methods, EarlyView.
We propose mild‐MHT protocol for the quick internalization of magnetic nanoparticles (MNPs) by immune cells. The heat induced by MNPs under alternating magnetic field stimulate MNPs diffusion and cell membrane invagination, accelerating the cellular internalization of MNPs. ABSTRACT Immune cell therapies show promise in hematologic malignancies and are
Giulia E. P. Nucci, Chiara Vitale, Alessandro di Girolamo, Niccolò Silvestri, Stefano Persano, Lorenci Gjurgjaj, Cristina Bottino, Roberta Castriconi, Teresa Pellegrino   +8 more
wiley   +1 more source

Unraveling the Physicochemical Landscape of Organoselenium Compounds in Nanocarrier Systems

The Chemical Record, EarlyView.
Main nanocarriers employed to enhance the bioavailability and transport of organoselenium compounds. The image illustrates the key interaction forces that stabilize these organoselenium species in solution, enabling their application in drug delivery systems, catalysis, photoelectronic devices, and sensing technologies. In recent years, publications on
Romelly Eugenia Rojas Ramírez, Tielle Moraes de Almeida, Daiani Canabarro Leite, Gilson Zeni   +3 more
wiley   +1 more source

Urinary symmetric dimethylarginine: A promising biomarker for acute kidney injury in dogs with pyometra

Veterinary Record, EarlyView.
Abstract Background Symmetric dimethylarginine (SDMA) is a biomarker of renal function derived from arginine methylation, unaffected by muscle mass or diet, and increases after only a 25% reduction in renal function, allowing earlier detection of renal dysfunction compared with serum creatinine.
Larissa Ayane do Nascimento Braz, Suellen Rodrigues Maia, Lara Vilela Soares, Natani Silva Reis, Leandro Zuccolotto Crivellenti, Andrigo Barboza de Nardi   +5 more
wiley   +1 more source

β2- and α2-adrenergic receptors and receptor coupling to adenylate cyclase in human mononuclear leukocytes and platelets in relation to physiological variations of sex steroids

, 1984
β2- and α2-adrenergic receptors and receptor coupling to adenylate cyclase in human mononuclear leukocytes and platelets in relation to physiological variations of sex ...
PE CRYER (14529260), MA BERK (14529203), EB SMITH (14529266), AM GINSBERG (14529269), WE CLUTTER (14529254), DA POPP (14529263), SG ROSEN (14529251), P SERUSCLAT (13537057), SD SHAH (14529257)   +8 more
core  

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source