Results 181 to 190 of about 403,834 (312)

Eliminating circulating donor passenger leukocytes during clinical ex vivo lung perfusion does not attenuate inflammation. [PDF]

JHLT Open
Hu MA, Zhang ZL, Hoffmann RF, Gan CT, Verschuuren EAM, Van De Wauwer C, Leuvenink HGD, Erasmus ME.   +7 more
europepmc   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Decoding radiation-induced transcriptomic signatures of human leukocytes using long-read RNA-seq: clinical and biodosimetric implications. [PDF]

BMC Genomics
Salah A, Schmidberger H, Marini F, Zahnreich S.   +3 more
europepmc   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

8-Iso-Prostaglandin F2α and Lipoxygenase Gene Expression as Candidate Molecular Markers of Training Adaptation in Professional Volleyball Players: A Pilot Study. [PDF]

Int J Mol Sci
Baran K, Podgórski R, Grzesik-Pietrasiewicz M, Czarny W, Król P, Połeć J, Gouveia ÉR, Cieśla M.   +7 more
europepmc   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Like father, like daughter: amoxicillin-induced aseptic meningitis in a female patient and her father: a case report. [PDF]

J Med Case Rep
Farhood I, Seidel S, Kaeder M, Schönlau L, Seliger C.   +4 more
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

IL-21 controls CD8 ⁺ T cell immunity and antibacterial defense in fish via STAT3 signaling. [PDF]

Zool Res
Cao Y, Rao W, Chen H, Li K, Zhu Y, Fang Z, Zheng Y, Geng M, Zhang J, Yang J, Wei X.   +10 more
europepmc   +1 more source

Basal Plane Graphene Coated Zn Powder for High Performance Aqueous Zn Metal Batteries

Advanced Science, EarlyView.
A mechanofusion‐driven dry coating forms a hydrophobic graphene shell on Zn powder, stabilizing the electrode‐electrolyte interface. This basal‐plane‐rich protective layer modifies the Zn2+ solvation environment and promotes preferential growth along the (002) plane, suppressing dendrite and parasitic reactions.
Dongju Kim, Daebeom Jeong, Kijung Kim, Van‐Chuong Ho, Jongsoon Kim, Hun‐Gi Jung, Jung Ho Kim, Goojin Jeong, Junyoung Mun   +8 more
wiley   +1 more source