Results 231 to 240 of about 375,888 (308)

Vaccine-Mediated Protection of Mice Against African and Asian Clinical Strains of <i>Cryptococcus neoformans</i>. [PDF]

J Fungi (Basel)
Carlson D, Wang R, Hastings Z, Oliveira LVN, Hester MM, Rodriguez N, Pedersen GK, Tenor JL, Perfect JR, Specht CA, Levitz SM.   +10 more
europepmc   +1 more source

Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant.

, 1994
S. Natsuka, K.M. Gersten, K. Zenita, R. Kannagi, J.B. Lowe   +4 more
openalex   +1 more source

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

Neighborhood deprivation, breast cancer outcomes and stress-related gene expression in leukocytes and tumor tissue. [PDF]

Breast Cancer Res
Shen J, Guan Y, Boyle J, Fuemmeler BF, Zhao H.   +4 more
europepmc   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Taxonomic Profiling of Systemic Inflammatory Parameters as Predictors of Tumor Progression in Primary Colorectal Cancer. [PDF]

J Clin Med
Nycz M, Waniczek D, Muc-Wierzgoń M, Snopek-Miśta K, Kryj M, Bichalski B, Bichalska-Lach M, Michalecki Ł, Krawczyk W, Lorenc Z.   +9 more
europepmc   +1 more source

Stress‐Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer

Advanced Science, EarlyView.
Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Zhibo Shao, Xuliren Wang, Han Zhu, Ling Yao, Qi Zhang, Zihan Zhai, Xinyi Lv, Xinyuan Xia, Yi Zhang, Xinya Lu, Xinyi Quan, Jiawen Yang, Xinwei Li, Jieyi Dong, Zhi‐ming Shao, Ruoxi Wang, Bingqiu Xiu, Jiong Wu, Sheng Chen   +18 more
wiley   +1 more source

GPR35 mediates monocyte recruitment to the sites of Listeria monocytogenes infection. [PDF]

Cell Mol Life Sci
Okamura Y, Nakanishi K, Inada R, Maeda R, Maeshima K, Mizutani M, Ohashi W, Ikawa M, Sugiura Y, Takeda K, Umemoto E.   +10 more
europepmc   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Longitudinal Study of <i>TCF4</i> CTG Trinucleotide Repeat Length and Disease Severity in Fuchs' Endothelial Corneal Dystrophy. [PDF]

Med Sci (Basel)
Teo JXJ, Neo DJH, Choo JQH, Gong X, Li Z, Htoon HM, Chua MJ, Soh YQ, Mootha VV, Khor CC, Mehta JS.   +10 more
europepmc   +1 more source