Results 241 to 250 of about 375,888 (308)

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Pattern recognition receptor-associated immuno-thrombotic transcript changes in platelets and leukocytes with COVID19. [PDF]

PLoS Pathog
Learnard H, Core J, Corkrey H, Sciaudone A, Rade J, Kornfeld H, Wang JP, Freedman JE, Tanriverdi K, Koupenova M.   +9 more
europepmc   +1 more source

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

Acute Effects of Exercise on Metabolic, Inflammatory, and Immune Markers in Adolescent Girls with Normal Weight or Overweight/Obesity. [PDF]

Sports (Basel)
Abassi W, Ouerghi N, Feki M, Marsigliante S, Bouassida A, Knechtle B, Vveinhardt J, Muscella A.   +7 more
europepmc   +1 more source

2'-5' oligo-A-synthetase activity in bovine peripheral blood leukocytes and alveolar macrophages exposed to recombinant interferons and tumor necrosis factor-alpha.

, 1989
H. Bielefeldt Ohmann, Marli Matiko Anraku de Campos, Philip Griebel, Lorne A. Babiuk   +3 more
openalex   +1 more source

Can “Rising Neutrophil Lymphocyte Ratio within the Normal Range of Total Leukocyte Count” be Considered as an Early and Economical Predictor of Sepsis in Critically Ill Trauma Patients?

FNU Kairidibo, Swati Taneja
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Growth factor and cell content in Platelet-Rich Plasma (PRP), Leukocyte- and Platelet-Rich Plasma (L-PRP), Platelet-Rich Fibrin (PRF) in patients with long bone defects from combat injuries. [PDF]

BMC Musculoskelet Disord
Husak V, Povelychenko O, Maltseva V, Romanenko K, Vorontsov P, Pazdnikov R.   +5 more
europepmc   +1 more source

NIR‐Activatable Domino Cascade Catalysis Nanozyme Reactor for Multi‐Mechanism Synergistic Immunotherapy in Bladder Cancer

Advanced Science, EarlyView.
This study presents an intravesical delivery strategy of ferroptosis‐ and immunity‐inducing nanozyme‐loaded thermoresponsive hydrogels (FMCC@PNH) for enhanced bladder cancer therapy. Abstract Current intravesical therapies for bladder cancer after resection are limited by poor tissue penetration, off‐target effects, and insufficient efficacy.
Yongnan Jiang, Qingling Zhang, Yuhan Zhang, Xinlu Yu, Bo Jia, Yulong Dong, Yalong Wu, Kelong Fan, Xinquan Gu, Lei Ji, Wei Jiang, Bin Liu   +11 more
wiley   +1 more source

Development of an immunodeficient mouse that allows for conditional ablation of monocytic cells. [PDF]

Front Immunol
Hui AJ, Lai K, Doyle EH, Rivera-Torruco G, Gutierrez AG, Du EJ, Meijer YBM, Smith G, Gilfanova R, Chung KG, Auclair KM, Milani P, Jackman RP, Tran JQ, Muench MO.   +14 more
europepmc   +1 more source