Results 91 to 100 of about 32,319 (241)

Genetic Leukoencephalopathies in Adults [PDF]

Continuum, 2016
More than 100 heritable disorders can present with abnormal white matter on neuroimaging. While acquired disorders remain a more common cause of leukoencephalopathy in the adult than genetic causes, the clinician must remain aware of features that suggest a possible genetic etiology.The differential diagnosis of heritable white matter disorders in ...
openaire   +2 more sources

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

A case of developing progressive multifocal leukoencephalopathy while using rituximab and mycophenolate mofetil in refractory systemic lupus erythematosus

, 2018
Yuichi Ishikawa, Tadamichi Kasuya, Junichi Ishikawa, Michio Fujiwara, Yasuhiko Kita Department of Rheumatology, Yokohama Rosai Hospital, Kohoku-ku, Yokohama, Kanagawa, Japan Abstract: Progressive multifocal leukoencephalopathy (PML) is a central ...
Fujiwara M, Ishikawa Y, Ishikawa J, Kita Y, Kasuya T   +4 more
core  

Capecitabine-induced acute toxic leukoencephalopathy

, 2017
International audienceA 45-year-old woman was treated by Capecitabine (Xeloda®) during 6 days for breast cancer with metastatic bone lesions when she presented with nausea, headaches, muscle cramps, dysarthria and swallowing disorders. A stroke was first
D. Galanaud, Galanaud, Damien, D. Psimaras, Obedia, Michael, J. Wasserman, D. Dormont, Law-Ye, Bruno, N. Pyatigorskaya, Amor-Sahli, Mélika, B. Law-ye, Leclercq, Delphine, D. Leclercq, M. Sahli-Amor, Wassermann, Johanna, Pyatigorskaya, Nadya, Psimaras, Dimitri, M. Obadia   +16 more
core   +1 more source

When colony‐stimulating factor 1 receptor (CSF1R) breaks the mold

Developmental Medicine &Child Neurology, EarlyView.
Claire Henchcliffe
wiley   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 2138-2142, October 2026.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab

, 2018
Progressive multifocal leukoencephalopathy (PML) is increasingly being reported in patients undergoing immunotherapy. We report a case of progressive multifocal leukoencephalopathy after treatment with nivolumab, a PD-1 blocker that is used to restore ...
Guido Ahle, Camille Martinez, Samira Fafi-Kremer, Inesa Petrosyan, Martin Martinot, Mahsa Mohseni-Zadeh, Dragos M. Gorun, Martine Tebacher-Alt   +7 more
core   +1 more source

Magnetic resonance imaging of changes in the brain of children cured of acute lymphoblastic leukemia

Hematology Reports, 2019
This study was aimed to systematize magnetic resonance imaging (MRI) presentation of toxic leukoencephalopathy, to find the correlation between method of central nervous system (CNS) leukemia prevention and changes on MRI, to find relationship between ...
Vladislav P. Bondarenko, Galina V. Tereschenko, Mikhail M. Andrianov, Yulia V. Rumyantseva, Alexander I. Karachunsky, Vladimir N. Kasatkin, Alexander F. Karelin, Viktor N. Anisimov, Elena V. Zhukovskaya, Alexander G. Rumyantsev   +9 more
doaj   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, Volume 13, Issue 56, 9 October 2026.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Possible Occurrence of Delayed Leukoencephalopathy Following Acute Ischemic Stroke With Large‐Vessel Occlusion

Stroke: Vascular and Interventional Neurology
Background Typically detected at least 14 days after acute ischemic stroke onset, delayed leukoencephalopathy (DL) involves diffuse hyperintensities restricted to white matter on fluid‐attenuated inversion recovery accompanied mostly by partial diffusion‐
Takeo Sato, Satoshi Matsushima, Motohiro Okumura, Takahiro Maku, Tomomichi Kitagawa, Maki Tanabe, Hiroki Takatsu, Teppei Komatsu, Kenichiro Sakai, Kenichi Sakuta, Tadashi Umehara, Hidetomo Murakami, Hidetaka Mitsumura, Masato Matsushima, Yasuyuki Iguchi   +14 more
doaj   +1 more source