Results 111 to 120 of about 48,917 (272)

Annual 12‐Week Dosing Gap of Natalizumab: Clinical Efficacy, Blood Biomarkers, and CSF Cell Composition

Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 85-96, January 2026.
ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich, Tilman Schneider‐Hohendorf, Eric Baetscher, Evan L. Riddle, Marie Deffner, Emily Katsnelson, Janine Ferrant‐Orgettas, Julie Czerkowicz, John Anderson, Susan E. Goelz, Nicholas Schwab   +10 more
wiley   +1 more source

Case report: Exploring chemoradiotherapy-induced leukoencephalopathy with 7T imaging and quantitative susceptibility mapping

Frontiers in Neurology
Chemotherapy and radiotherapy are widely used in the treatment of central nervous system tumors and acute lymphocytic leukemia even in the pediatric population.
Gaetano Celardo, Gaetano Celardo, Elena Scaffei, Bianca Buchignani, Bianca Buchignani, Graziella Donatelli, Graziella Donatelli, Mauro Costagli, Mauro Costagli, Paola Cristofani, Raffaello Canapicchi, Rosa Pasquariello, Michela Tosetti, Roberta Battini, Roberta Battini, Laura Biagi   +15 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy: new concepts

Arquivos de Neuro-Psiquiatria, 2013
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the CNS caused by reactivation of JC virus (JCV) in a setting of cellular immunosuppression.
Marco A. Lima
doaj   +1 more source

Evaluation of gene-based family-based methods to detect novel genes associated with familial late onset Alzheimer disease [PDF]

, 2018
Gene-based tests to study the combined effect of rare variants towards a particular phenotype have been widely developed for case-control studies, but their evolution and adaptation for family-based studies, especially for complex incomplete families ...
Budde, John, Cruchaga, Carlos, Del-Aguila, Jorge L, Deming, Yuetiva, Fernandez, Maria V, Goate, Alison M, Harari, Oscar, Ibanez, Laura, Morris, John C, NCRAD,, NIA-LOAD family study group,, Norton, Joanne   +11 more
core   +2 more sources

The Case of a 25‐Year‐Old Woman With Isolated Head Tremor

Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 209-211, January 2026.
ABSTRACT This study reported a 25‐year‐old woman with isolated head tremors as the main manifestation, along with type 1 diabetes, bilateral hearing loss, and leukoencephalopathy, who was diagnosed with mitochondrial disease due to a single large mtDNA deletion (m.8647‐16082del).
Ying Zhao, Zhihong Xu, Xingyu Zhuang, Yuying Zhao, Chuanzhu Yan, Kunqian Ji   +5 more
wiley   +1 more source

Global Research Trends and Hotspots in Cerebral Small Vessel Disease‐Related Cognitive Impairment: A Bibliometric Analysis (2001–2024)

Brain and Behavior, Volume 16, Issue 1, January 2026.
This bibliometric study systematically analyzed 1074 publications in the field of CSVD‐CI from 2001 to 2024. The research reveals three evolutionary phases and identifies four core research clusters: pathophysiological mechanisms, neuroimaging biomarkers, clinical assessment, and therapeutic interventions.
Kuihua Wang, Xiaohui Ji, Hui Li, Xiaoyang Wang, Xiaoyue Jin, YanJun Lin, Qiao Wang, Haizhen Xu, Jianxin Ye, Xiaoping Cui, Yonghui Liang   +10 more
wiley   +1 more source

Interventions for neurocognitive dysfunction [PDF]

, 2017
Purpose of review: To evaluate current barriers to HIV cure strategies and interventions for neurocognitive dysfunction with a particular focus on recent advancements over the last three years. Recent findings: Optimal anti-retroviral therapy (ART) poses
Brew, B, Ellero, J, Lubomski, M
core   +2 more sources

Brain magnetic resonance imaging findings in adult patients with congenital adrenal hyperplasia: Increased frequency of white matter impairment and temporal lobe structures dysgenesis

Indian Journal of Endocrinology and Metabolism, 2013
Background: Congenital adrenal hyperplasia (CAH) is an inherited recessive disorder of adrenal steroidogenesis. The enzymes most commonly affected are 21-hydroxylase.
Mouna Feki Mnif, Mahdi Kamoun, Fatma Mnif, Nadia Charfi, Nozha Kallel, Nabila Rekik, Basma Ben Naceur, Hela Fourati, Emna Daoud, Zainab Mnif, Mohamed Habib Sfar, Samia Younes-Mhenni, Mohamed Tahar Sfar, Mongia Hachicha, Mohamed Abid   +14 more
doaj   +1 more source

Liver Transplantation and Other Hepatically Directed Therapies Do Not Change the Biochemical Phenotype nor Halt Progression of Leukodystrophy due to Biallelic HMBS Variants: A Case Report

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Leukodystrophy due to biallelic HMBS variants is a rare condition distinct from acute intermittent porphyria (AIP). It is characterised by progressive leukoencephalopathy rather than acute attacks of neurovisceral symptoms. We report the ongoing clinical progression of a patient with leukodystrophy due to homozygous variants in HMBS [c.251C>A,
Jeremy Clark, Joel Smith, Yoke Leong, Virginia Cronin, Ingrid Winship, Gayle Ross, Timothy Fazio   +6 more
wiley   +1 more source

Possible Occurrence of Delayed Leukoencephalopathy Following Acute Ischemic Stroke With Large‐Vessel Occlusion

Stroke: Vascular and Interventional Neurology
Background Typically detected at least 14 days after acute ischemic stroke onset, delayed leukoencephalopathy (DL) involves diffuse hyperintensities restricted to white matter on fluid‐attenuated inversion recovery accompanied mostly by partial diffusion‐
Takeo Sato, Satoshi Matsushima, Motohiro Okumura, Takahiro Maku, Tomomichi Kitagawa, Maki Tanabe, Hiroki Takatsu, Teppei Komatsu, Kenichiro Sakai, Kenichi Sakuta, Tadashi Umehara, Hidetomo Murakami, Hidetaka Mitsumura, Masato Matsushima, Yasuyuki Iguchi   +14 more
doaj   +1 more source