Results 11 to 20 of about 32,319 (241)

CADASIL: A monogenic condition causing stroke and subcortical vascular dementia [PDF]

, 2002
Mutations in Notch3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an inherited small vessel disease leading to subcortical strokes and vascular dementia. The phenotypic presentation
Dichgans, Martin
core   +1 more source

Case report: Bilateral globus pallidus lesions and delayed progressive leukoencephalopathy in COVID-19: Effects of hypoxia alone or combination of hypoxia and inflammation?

Frontiers in Neurology, 2023
BackgroundThe globus pallidus is a highly mitochondria-rich metabolic structure that is particularly sensitive to metabolic disturbances and hypoxia. Symmetric lesions of globus pallidus and delayed diffuse leukoencephalopathy were documented in toxic ...
Ahmad A. Ballout, Michael Kolesnik, Yuna Choi, Marc S. Ayoub, Asaff Harel, Souhel Najjar   +5 more
doaj   +1 more source

Clinicoradiographic and genetic features of cerebral small vessel disease indicate variability in mode of inheritance for monoallelic HTRA1 variants

Molecular Genetics & Genomic Medicine, 2021
Background Biallelic pathogenic variants in HTRA1 cause CARASIL. More recently, monoallelic variants have been associated with the autosomal dominant disorder CADASIL2 but not all carriers develop disease manifestations. We describe the clinicoradiologic
Karthik Muthusamy, Alejandro Ferrer, Eric W. Klee, Klaas J. Wierenga, Ralitza H. Gavrilova   +4 more
doaj   +1 more source

Case report: Reversible encephalopathy associated with liposomal amphotericin B in a patient with cryptococcal meningitis

Frontiers in Neurology, 2022
Liposomal amphotericin B (L-AMB) is an anti-fungus medicine that has fewer side effects than traditional amphotericin B (AMB). Neurotoxicity of L-AMB has rarely been observed, and only one case of leukoencephalopathy during intravenous L-AMB has been ...
Si Luo, Han Wen, Meihong Zhou, Chengsi Wu, Daojun Hong   +4 more
doaj   +1 more source

Case Report: MRI, Clinical, and Pathological Correlates of Bromethalin Toxicosis in Three Dogs

Frontiers in Veterinary Science, 2022
Bromethalin toxicosis is an increasingly common clinical presentation in dogs that may be fatal depending on the extent of intoxication. Antemortem diagnosis of bromethalin toxicosis was achieved in three dogs by demonstration of the active metabolite ...
Vishal D. Murthy, Ehren McLarty, Kevin D. Woolard, Rell L. Parker, Gregg Kortz, Jamie N. King, Robert H. Poppenga, Marguerite F. Knipe, Peter J. Dickinson   +8 more
doaj   +1 more source

Cystic leukoencephalopathy [PDF]

, 2014
How to Cite this Article: Ashrafi MR, Tavasoli AR. Cystic leukoencephalopathy. Iran J Child Neurol. Autumn 2014; 8:4(suppl.
ASHRAFI, Mahmoud Reza, TAVASOLI, Alireza
core   +1 more source

Microglial replacement therapy: a potential therapeutic strategy for incurable CSF1R-related leukoencephalopathy

Acta Neuropathologica Communications, 2020
CSF1R-related leukoencephalopathy is an adult-onset leukoencephalopathy with axonal spheroids and pigmented glia caused by colony stimulating factor 1 receptor (CSF1R) gene mutations.
Jinming Han, Heela Sarlus, Zbigniew K. Wszolek, Virginija Danylaité Karrenbauer, Robert A. Harris   +4 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy [PDF]

Tidsskrift for Den norske legeforening, 2017
Progressive multifocal leukoencephalopathy is a rare, opportunistic infection of the central nervous system caused by the John Cunningham virus (JCV). There is no effective antiviral treatment available, and restoring immunocompetence is essential for survival. If this occurs too quickly, however, the inflammatory response may prove fatal.
Christine Hanssen Rinaldo, Kjell-Morten Myhr, Karl Bjørnar Alstadhaug   +2 more
openaire   +2 more sources

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL): first description of a Russian family with the identified mutation in the Notch3 gene

Анналы клинической и экспериментальной неврологии, 2017
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a recently described familial form of ischemic stroke caused by mutations in the Notch3 gene on chromosome 19q12.
S. N. Illarioshkin, P. A. Slominsky, M. I. Shadrina, M. V. Partola, D. V. Kandyba, N. M. Zhulev   +5 more
doaj   +1 more source

Adult-onset leukodystrophies: a practical guide, recent treatment updates, and future directions

Frontiers in Neurology, 2023
Adult-onset leukodystrophies though individually rare are not uncommon. This group includes several disorders with isolated adult presentations, as well as several childhood leukodystrophies with attenuated phenotypes that present at a later age ...
Karthik Muthusamy, Ajith Sivadasan, Luke Dixon, Sniya Sudhakar, Maya Thomas, Sumita Danda, Zbigniew K. Wszolek, Klaas Wierenga, Radhika Dhamija, Ralitza Gavrilova   +9 more
doaj   +1 more source