Results 31 to 40 of about 32,319 (241)

Concurrent progressive multifocal leukoencephalopathy and central nervous system infiltration by multiple myeloma: A case report

, 2018
Progressive multifocal leukoencephalopathy rarely occurs in patients with multiple myeloma. Intracranial central nervous system invasion is also an uncommon event in multiple myeloma, occurring in less than 1% of cases. We describe herein an exceptional
Yanira Ruiz-Heredia, Hernández Laín, Aurelio, Inmaculada Rapado, Luis Collado, Santiago Barrio, Keith Stewart, Ruiz Heredia, Yanira, Joaquin Martinez-Lopez, Juan Ruiz, Oscar Toldos, Linares Gómez, María, Braggio, Esteban, Esteban Braggio, Aurelio Hernandez-Lain, Rapado, Inmaculada, Toldos González, Óscar, Collado Yurrita, Luis Rodolfo, Ana Ramos, Stewart, Keith, María Linares, Sánchez Vega, Beatriz, Martínez López, Joaquín, Ruiz Albusac, Juan Miguel, M Dolores Folgueira, Beatriz Sanchez-Vega, Ramos González, Ana, Barrio, Santiago, Folgueira López, María Dolores   +27 more
core   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Central and Extrapontine Myelinolysis Affecting the Brain and Spinal Cord. An Unusual Presentation of Pancreatic Encephalopathy

Frontiers in Neurology, 2012
: Pancreatic encephalopathy refers to a gamut of neuropsychiatric symptoms complicating acute pancreatitis. Osmotic myelinolisis is a known complication of pancreatic encephalopathy.
Jose eBiller, Alejandro eHornik, Federico eRodriguez-Porcel, Caroline eAgha, Murray eFlaster, Sarkis Gibran eMorales Vidal, Michael J Schneck, John eLee   +7 more
doaj   +1 more source

Generation of a heterozygous and a homozygous CSF1R knockout line from iPSC using CRISPR/Cas9

Stem Cell Research, 2023
Mutations in Colony-stimulating factor 1 receptor (CSF1R) lead to CSF1R-related leukoencephalopathy, also known as Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rapidly progressing neurodegenerative disease with ...
Anne S. Schmitz, Milena Korneck, Janani Raju, Andrés Lamsfus-Calle, Alberto Daniel-Moreno, Justin S. Antony, Markus Mezger, Ludger Schöls, Stefan Hauser, Stefanie N. Hayer   +9 more
doaj   +1 more source

Repeat expansions in leukoencephalopathy [PDF]

Annals of Neurology, 2019
Peer Reviewed ; https://deepblue.lib.umich.edu/bitstream/2027.42/152577/1/ana25613.pdf ; https://deepblue.lib.umich.edu/bitstream/2027.42/152577/2/ana25613_am ...
openaire   +3 more sources

Progressive multifocal leukoencephalopathy [PDF]

Neurology, 2002
A 58-year-old woman admitted to the hospital had a 3-month history of progressive neurologic deterioration characterized by severe global aphasia and bilateral limb weakness, greater on the right. The patient had a 10-year history of systemic lupus erythematosus (SLE). Polyarthritis had been present for 6 weeks before the …
Henderson, R. D., Smith, M. G., Mowat, P., Read, S. J.   +3 more
openaire   +4 more sources

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

Arthritis &Rheumatology, EarlyView.
Objective TypeI interferonopathies are heterogeneous diseases driven by dysregulated type I interferon (IFN‐I) signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. The aim of this study was to characterize the clinical, immunologic, genetic, molecular profiles of patients with suspected ...
Ismail Yaz, Seza Ozen, Hacer Neslihan Bildik, Canberk Ipsir, Dilara Unal, Saliha Esenboga, Begum Cicek, Mehmet Emin Seker, Fatima Aerts‐Kaya, Seher Sener, Mehmet Orhan Erkan, Hanife Avci, Deniz Cagdas, Ilhan Tezcan   +13 more
wiley   +1 more source

Evaluating discrepancies between high‐yield neuroscience conditions in preclerkship medical education and national clinical incidence

Anatomical Sciences Education, EarlyView.
Abstract Medical education must balance foundational science with clinical relevance. Increasing emphasis on standardized assessments has led to prioritization of “high‐yield” conditions—those most likely to be assessed. Subsequently, educators and students often prioritize these conditions.
Kathryn Veazey, Oheneba Boadum
wiley   +1 more source

MRI in Chemotherapy induced Leukoencephalopathy: Report of Two Cases and Radiologist’s Perspective [PDF]

Journal of Clinical and Diagnostic Research, 2017
Leukoencephalopathy is a progressive white matter disease primarily caused due to myelin damage by a variety of factors. Chemotherapy for oncological treatment is an uncommon but important cause of potentially reversible leukoencephalopathy. In current
Geetika Sindhwani, Manali Arora, Vishal Dhirenbhai Thakker, Abhinav Jain   +3 more
doaj   +1 more source

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source