Results 191 to 200 of about 32,319 (241)

MRI in methotrexate-related leukoencephalopathy: Disseminated necrotising leukoencephalopathy in comparison with mild leukoencephalopathy

Neuroradiology, 2003
We report two fatal cases of methotrexate (MTX)-induced disseminated necrotising leukoencephalopathy (DNL) in which MRI was repeated from the onset. Initial T2-weighted images showed multiple areas of high signal, mainly in deep cerebral white matter, which on follow-up, spread and coalesced to involve the entire white matter.
M, Oka, S, Terae, R, Kobayashi, Y, Sawamura, K, Kudoh, K K, Tha, M, Yoshida, M, Kaneda, Y, Suzuki, K, Miyasaka   +9 more
openaire   +2 more sources

Sickle cell disease and posterior reversible leukoencephalopathy

Journal of Clinical Neuroscience, 2014
Sickle cell disease can present with neurological manifestations. One such presentation is with posterior reversible leukoencephalopathy also known as reversible posterior leukoencephalopathy.
Merrilee Needham, Geoffrey Herkes, Nimeshan Geevasinga   +2 more
exaly   +1 more source

LEUKOENCEPHALOPATHIES AND LEUKODYSTROPHIES

Continuum, 2010
The leukoencephalopathies encompass a heterogeneous group of disorders that involve the brain white matter. The cause may be acquired or inherited; in the latter case, mutations have been found in genes that encode protein components of the myelin membrane or enzymes implicated in the turnover of myelin. In patients with cognitive dysfunction and white
openaire   +2 more sources

Toxic Leukoencephalopathies

Psychiatric Clinics of North America, 2011
Leukoencephalopathy is a syndrome of neurologic deficits, including alteration of mental status, caused by pathologic changes in the cerebral white matter. The term, toxic leukoencephalopathy, encompasses a wide variety of exposures and clinical presentations.
openaire   +3 more sources

Cree Leukoencephalopathy and Other Leukoencephalopathies Involving Arcuate Fibers

Radiology, 2001
Editor: We read with great interest the article by Dr Alorainy and colleagues in the November 1999 issue of Radiology (1). The authors nicely presented computed tomographic and magnetic resonance (MR) imaging findings of a rare and lethal disorder, Cree leukoencephalopathy, in 12 patients whose diagnoses were made clinically or at autopsy.
U, Senol, K, Karaali
openaire   +2 more sources

Toxic leukoencephalopathies

Toxic-metabolic encephalopathies are a group of disorders in which an exogenous or endogenous substance leads to transient or permanent neuronal damage. It is an important cause of potentially reversible acute encephalopathy syndrome. The signs and symptoms of toxic encephalopathies may be relatively nonspecific, and toxicologic tests are not always ...
Gabriela Alencar, Bandeira, Leandro Tavares, Lucato   +1 more
openaire   +2 more sources

Leukoencephalopathies and metabolic diseases

Neurological Sciences, 2008
Leukoencephalopathies and metabolic diseases comprise a great number of heterogeneous disorders. Diagnosis of these disorders may be challenging at times, requiring sophisticated laboratory investigations. Magnetic resonance imaging (MRI) is useful in supporting diagnosis even though it bears problems of specificity.
GIORGIO A., DE STEFANO N.
openaire   +3 more sources

Infectious leukoencephalopathies

Leukoencephalopathy from infectious agents may have a rapid course, such as human simplex virus encephalitis; however, in many diseases, it may take months or years before diagnosis, such as in subacute sclerosing panencephalitis or Whipple disease. There are wide geographic distributions and susceptible populations, including both immunocompetent and ...
David, Jakabek, Joga, Chaganti, Bruce James, Brew   +2 more
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Advances in the diagnosis of leukoencephalopathies

Expert Opinion on Medical Diagnostics, 2012
Introduction : Leukoencephalopathies (LEs) are a diverse group of diseases involving cerebral white matter. Some of the disorders may be infectious or immunologically mediated and, therefore, tend to be more amenable to treatment. Most of these disorders have a genetic basis, for which genetic counseling becomes important as currently very few of them ...
Sakkubai, Naidu, Doris D M, Lin
openaire   +2 more sources

Toxic Leukoencephalopathy

2012
The white matter of the brain is vulnerable to a wide variety of toxins. Leukoencephalopathy is being increasingly recognized in a number of different patient populations. The detection of early and subtle toxin effects has been facilitated by the advent of magnetic resonance imaging, which offers better resolution of white matter than other ...
openaire   +2 more sources