Results 61 to 70 of about 43,716 (281)

COVID-19-associated leukoencephalopathy in the absence of severe hypoxia with subsequent improvement: a case report

BMC Infectious Diseases, 2022
Background Several cases of coronavirus disease 2019 (COVID-19)-associated leukoencephalopathy have been reported. Although most cases involve hypoxia, the pathophysiological mechanism and neurologic outcomes of COVID-19-associated leukoencephalopathy ...
Hiroki Kojima, Naoya Sakamoto, Atsushi Kosaka, Masayoshi Kobayashi, Mitsuo Amemiya, Takuya Washino, Yusuke Kuwahara, Takuto Ishida, Mayu Hikone, Satoshi Miike, Tatsunori Oyabu, Sentaro Iwabuchi, Fukumi Nakamura-Uchiyama   +12 more
doaj   +1 more source

Leukoencephalopathy hypomyelination with brainstem and spinal cord involvement and leg spasticity caused by DARS1 mutations

Frontiers in Genetics, 2023
Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL), caused by aspartyl-tRNA synthetase (DARS1) gene mutations, is extremely rare, with only a few cases reported worldwide; thus, reports on HBSL treatment are few. In this
Jingyi Zhu, Xiaomin Guo, Ningjing Ran, Jingtao Liang, Fuyou Liu, Junyan Liu, Rongyu Wang, Lianyan Jiang, Dongdong Yang, Meijun Liu   +9 more
doaj   +1 more source

NIHSS Scores in Ischemic Small Vessel Disease: A Study in CADASIL [PDF]

, 2012
Background: The National Institutes of Health Stroke Scale (NIHSS) is widely used to measure neurological deficits, evaluate the effectiveness of treatment and predict outcome in acute ischemic stroke.
Allili, Nassira, Chabriat, Hugues, Dichgans, Martin, Duering, Marco, Herve, Dominique, Jouvent, Eric, Yao, Ming   +6 more
core   +1 more source

Long‐term risk and characteristics of cerebrovascular events after upper body radiotherapy among childhood cancer survivors in the DCCSS‐LATER cohort

International Journal of Cancer, Volume 156, Issue 10, Page 1858-1872, 15 May 2025.
What's new? Due to the nature of cancer treatments, childhood cancer survivors have an increased risk of serious adverse events later in life. Here, the authors examined the incidence of cerebrovascular events (CVEs) among childhood cancer survivors who had received upper body radiotherapy.
Lisanne C. Verbruggen, Judith L. Kok, Leontien C. M. Kremer, Geert O. Janssens, Paul J. Nederkoorn, Adriaan Penson, A. Birgitta Versluijs, Andrica C. H. de Vries, Ardine M. J. Reedijk, Dorine Bresters, Eelco W. Hoving, Eline van Dulmen‐den Broeder, Jacqueline J. Loonen, Judith de Bont, Joyce Wilbers, Marloes Louwerens, Margriet van der Heiden‐van der Loo, Marry M. van den Heuvel‐Eibrink, Saskia M. F. Pluijm, Sebastian J. C. M. M. Neggers, Wim J. E. Tissing, Yvo B. W. E. M. Roos, Cécile M. Ronckers, Jop C. Teepen, Helena J. H. van der Pal, on behalf of the DCCSS‐LATER consortium, Jaap den Hartogh, Floor van Leeuwen, Irma van Dijk   +28 more
wiley   +1 more source

Reduced myelin contributes to cognitive impairment in patients with monogenic small vessel disease [PDF]

Alzheimers Dement
Abstract INTRODUCTION Myelin is pivotal for signal transfer and thus cognition. Cerebral small vessel disease (cSVD) is primarily associated with white matter (WM) lesions and diffusion changes; however, myelin alterations and related cognitive impairments in cSVD remain unclear.
Denecke J, Dewenter A, Lee J, Franzmeier N, Valentim C, Kopczak A, Dichgans M, Pirpamer L, Gesierich B, Duering M, Ewers M.   +10 more
europepmc   +2 more sources

A clinical review on megalencephaly: A large brain as a possible sign of cerebral impairment. [PDF]

, 2017
Megalencephaly and macrocephaly present with a head circumference measurement 2 standard deviations above the age-related mean. However, even if pathologic events resulting in both megalencephaly and macrocephaly may coexist, a distinction between these ...
Corsello G, Falsaperla R, Parano E, Pavone P, Praticò AD, Rizzo R, Ruggieri M   +6 more
core   +1 more source

A homozygous mutation of alanyl‐transfer RNA synthetase 2 in a patient of adult‐onset leukodystrophy: A case report and literature review

Brain and Behavior, 2019
Introduction Leukodystrophy is a group of hereditary leukoencephalopathies predominantly affecting the white matter. Multiple genes and mutations have been reported to be associated with this disorder.
Jian‐Yong Wang, Song‐Fang Chen, Hong‐Qiu Zhang, Meng‐Yan Wang, Jian‐Hong Zhu, Xiong Zhang   +5 more
doaj   +1 more source

Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus [PDF]

, 2016
Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects.
Attarbaschi, Andishe, Barzilai, Shlomit, Escherich, Gabriele, Frandsen, Thomas Leth, Halsey, Christina, Hough, Rachael, Jeha, Sima, Kato, Motohiro, Liang, Der-Cherng, Mikkelsen, Torben Stamm, Moricke, Anja, Niinimaki, Riitta, Piette, Caroline, Putti, Maria Caterina, Raetz, Elizabeth, Schmiegelow, Kjeld, Silverman, Lewis B., Skinner, Roderick, Tuckuviene, Ruta, van der Sluis, Inge, Zapotocka, Ester   +20 more
core   +2 more sources

The Primary Microglial Leukodystrophies: A Review [PDF]

, 2022
Primary microglial leukodystrophy or leukoencephalopathy are disorders in which a genetic defect linked to microglia causes cerebral white matter damage.
Ferrer, Isidro (Ferrer Abizanda)
core   +1 more source

Long‐Read Sequencing: The Third Generation of Diagnostic Testing for Dystonia

Movement Disorders, EarlyView.
Abstract Long‐read sequencing methodologies provide powerful capacity to identify all types of genomic variations in a single test. Long‐read platforms such as Oxford Nanopore and PacBio have the potential to revolutionize molecular diagnostics by reaching unparalleled accuracies in genetic discovery and long‐range phasing.
Thomas Wirth, Kishore R. Kumar, Michael Zech   +2 more
wiley   +1 more source