Results 201 to 210 of about 82,211 (293)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Clinical Features and Factors Associated with Disease Severity in Acute Chikungunya Fever: A Retrospective Analysis. [PDF]

Infect Drug Resist
Lin H, Xie S, Li K, Chen Z, Wang Y.
europepmc   +1 more source

Host Transcriptomics and Culture‐Independent Testing for the Management of Febrile Neutropenia: Data From an Observational Study Conducted in a Bone Marrow Transplant Unit

European Journal of Haematology, Volume 116, Issue 5, Page 625-634, May 2026.
ABSTRACT Background Managing febrile neutropenia is challenging due to the limited sensitivity of blood culture (BC) and the lack of tools differentiating infectious from non‐infectious fever. T2 magnetic resonance (T2MR) is a culture‐independent system detecting bacteria (T2Bacteria) and yeasts (T2Candida); SeptiCyte RAPID is a host response assay ...
Anna Maria Peri, Andrea S. Henden, Ricky Nelles, Mark D. Chatfield, Patrick N. A. Harris, Glen Kennedy, David L. Paterson   +6 more
wiley   +1 more source

Durvalumab–Tremelimumab in Advanced Hepatocellular Carcinoma: Real‐World Data From the LOR‐HCC (Lombardy Real‐World HCC Group)

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background and Aim Dual immune checkpoint blockade with tremelimumab plus durvalumab (STRIDE) is an established first‐line therapy for unresectable hepatocellular carcinoma (uHCC); however, real‐world evidence on its safety, toxicity kinetics and liver function dynamics remains limited.
Andrea Casadei‐Gardini, Lorenzo Canova, Federica Tosi, Silvia Camera, Elisa Bocchero, Pietro Pozzoni, Martina Torchio, Salvatore Corallo, Daniela Costantino, Annamaria Stagno, Giulia Grizzi, Rita Gengarle, Gianluca Tomasello, Nasim Ansarin, Mariangela Bruccoleri, Katia Bencardino, Mara Persano, Martina Pino, Alessia Riva, Sara Vavassori, Lorenzo Argiento, Chiara Mazzarelli, Massimo De Giorgio, Elena Rota Caremoli, Margherita Rimini, Tiziana Pressiani, Lorenza Rimassa, Massimo Iavarone   +27 more
wiley   +1 more source

Gene therapy via CRISPR/Cas9-mediated Cxcr4 disease allele inactivation reverses leukopenia in WHIM mice. [PDF]

J Clin Invest
Gao JL, Li Z, Calderon-Perez R, Pavek A, Kim L, McDermott DH, Murphy PM.   +6 more
europepmc   +1 more source

Clinical Patterns of Osteoarticular, Bone Marrow and Urogenital Paracoccidioidomycosis

Mycoses, Volume 69, Issue 5, May 2026.
ABSTRACT Background Paracoccidioidomycosis (PCM) is an endemic systemic mycosis in Latin America, classically characterized by pulmonary, mucosal and lymphatic involvement. Extrapulmonary manifestations affecting uncommon organs remain poorly characterized and may contribute to diagnostic delay and adverse outcomes. Methods We conducted a retrospective
Wdson Luis Lima Kruschewsky, Mariane Cappellini Stricagnolo, Mônica Scarpelli Martinelli Vidal, Gil Benard, Vítor Falcão de Oliveira, Tiago Alexandre Cocio, Adriana Satie Gonçalves Kono Magri, Marcello Mihailenko Chaves Magri   +7 more
wiley   +1 more source

Incidence and sex-related risk factors of linezolid-associated adverse drug reactions identified through electronic health records. [PDF]

Transl Clin Pharmacol
Baek S, Oh J, Yoon S, Yoon S, Chung JY.
europepmc   +1 more source

Clinical use of immunosuppressants [PDF]

, 2005
Fung, JJ, Schonder, KS, Starzl, TE, Weber, RJ   +3 more
core  

Evaluation of Serum Ferritin Levels and Their Correlation With Clinical Outcomes in Dengue Virus Infection in a Population of Older Adults

Tropical Medicine &International Health, Volume 31, Issue 5, Page 651-656, May 2026.
ABSTRACT Objectives Prior studies have associated elevated ferritin levels with worse dengue outcomes but data from older adults remain limited. The aim of this study is to evaluate the serum ferritin levels and their correlation with disease severity in a population of older adults.
Sacha Orberg Temer, Thaís Guimarães, Augusto Yamaguti, João Silva de Mendonça   +3 more
wiley   +1 more source

Sacituzumab govitecan in patients with metastatic breast cancer: pooled safety analysis of data from patients in North America, Europe, and Asia. [PDF]

ESMO Open
Rugo HS, Tolaney SM, Cortés J, Marmé F, de Azambuja E, Xu B, Sohn J, Naito Y, Valdez T, Gary D, Zhu J, Lai C, Bardia A.   +12 more
europepmc   +1 more source