Results 1 to 10 of about 60,422 (244)

Lymphopenia, Lymphopenia-Induced Proliferation, and Autoimmunity [PDF]

International Journal of Molecular Sciences, 2021
Immune homeostasis is a tightly regulated system that is critical for defense against invasion by foreign pathogens and protection from self-reactivity for the survival of an individual. How the defects in this system might result in autoimmunity is discussed in this review. Reduced lymphocyte number, termed lymphopenia, can mediate lymphopenia-induced
Ting-Ting Sheu, Bor-Luen Chiang, Chiang Bor-Luen   +2 more
exaly   +3 more sources

Lymphopenia in hospitalized patients and its relationship with severity of illness and mortality

PLoS ONE, 2021
BackgroundLymphopenia is associated with various pathologies such as sepsis, burns, trauma, general anesthesia and major surgeries. All these pathologies are clinically expressed by the so-called Systemic Inflammatory Response Syndrome which does not ...
Carmen Cuéllar, Juan CARLOS Andreu-Ballester   +1 more
exaly   +2 more sources

Lymphopenia Caused by Virus Infections and the Mechanisms Beyond

Viruses, 2021
Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune responses and impact the clinical course of acute viral infections ...
Zhidong Zhang, Jing Guo, Meera Prajapati   +2 more
exaly   +3 more sources

Impact of baseline lymphopenia on prognosis of patients with septic shock [PDF]

BMC Infectious Diseases
Background Sepsis is defined as life-threatening organ dysfunction due to a dysregulated host response to infection. Lymphocytes play an important role in sepsis, but little is known about the comparisons of different lymphopenia and non-lymphopenia ...
Yuan-Yuan Li, Yan Chen, Shan Li, Wei Jiang, Xiao-Yun Hu, Chun-Yao Wang, Run Dong, Li Weng, Jin-Min Peng, Bin Du   +9 more
doaj   +2 more sources

Possible Mechanisms of Lymphopenia in Severe Tuberculosis

Microorganisms, 2023
Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis). In lymphopenia, T cells are typically characterized by progressive loss and a decrease in their count results.
Fei Li, Yunjie Du, Dandan Chen
exaly   +3 more sources

The Impact of Azathioprine-Associated Lymphopenia on the Onset of Opportunistic Infections in Patients with Inflammatory Bowel Disease

PLoS ONE, 2016
BackgroundThiopurines are known to cause lymphopenia (
Jonas Zeitz, Gerhard Rogler, Michael Scharl   +2 more
exaly   +3 more sources

Lymphopenia predicted illness severity and recovery in patients with COVID-19: A single-center, retrospective study

PLoS ONE, 2020
The outbreak of SARS-CoV-2 began in December 2019 and rapidly became a pandemic. The present study investigated the significance of lymphopenia on disease severity.
Guangsen Zhang, Hongling Peng
exaly   +4 more sources

Lymphopenia in Esophageal Cancer: What Have We Learned?

Frontiers in Oncology, 2021
Lymphopenia caused by disease or treatment is frequent in patients with cancer, which seriously affects the prognosis of these patients. Immune checkpoint inhibitors (ICIs) have garnered attention as one of the most promising strategies for the treatment
Jia-Lin Wang, Jia-Lin Wang, Rong Ma, Wei Kong, Wei Kong, Ren Zhao, Ren Zhao, Yan-Yang Wang, Yan-Yang Wang   +8 more
doaj   +1 more source

A Systematic Review and Meta-analysis of the Impact of Radiation-Related Lymphopenia on Outcomes in High-Grade Gliomas

South Asian Journal of Cancer, 2022
Supriya Mallick Introduction Malignant gliomas are the most common primary malignant brain tumors and are typically treated with maximal safe surgical resection followed by chemoradiation.
Supriya Mallick, Anjali V.R, Prashanth Giridhar, Rituraj Upadhyay, Byung-Kyu Kim, Amrish Sharma, Hagar Elghazawy, Thiraviyam Elumalai, Vinod Solipuram, Cheng En Hsieh, Courtney Hentz, Abhishek A. Solanki, Jing Li, Dennis Pai Chan, Emily Ness, Bhanu Prasad Venkatesulu, David R. Grosshans   +16 more
doaj   +1 more source

Severe radiation-induced lymphopenia during concurrent chemoradiotherapy for stage III non-small cell lung cancer: external validation of two prediction models

Frontiers in Oncology, 2023
BackgroundSevere radiation-induced lymphopenia (RIL) in patients undergoing chemoradiotherapy (CRT) for non-small cell lung cancer (NSCLC) is associated with decreased immunotherapy efficacy and survival.
Peter S. N. van Rossum, Peter S. N. van Rossum, Celia Juan-Cruz, Barbara Stam, Maddalena M. G. Rossi, Steven H. Lin, Azadeh Abravan, Azadeh Abravan, José S. A. Belderbos, Jan-Jakob Sonke   +9 more
doaj   +1 more source