Results 1 to 10 of about 62,526 (160)
Lymphopenia, Lymphopenia-Induced Proliferation, and Autoimmunity [PDF]
International Journal of Molecular Sciences, 2021 Immune homeostasis is a tightly regulated system that is critical for defense against invasion by foreign pathogens and protection from self-reactivity for the survival of an individual. How the defects in this system might result in autoimmunity is discussed in this review. Reduced lymphocyte number, termed lymphopenia, can mediate lymphopenia-induced
Ting-Ting Sheu, Bor-Luen Chiang
exaly +3 more sources
Clinical Impact of Fingolimod-Associated Lymphopenia in Multiple Sclerosis: A Real-World Cohort Study [PDF]
MedicinaBackground and Objectives: Fingolimod, a sphingosine-1-phosphate receptor modulator, is an effective disease-modifying therapy for relapsing forms of multiple sclerosis (MS).
Murat Yeniçeri +6 more
doaj +2 more sources
Lymphopenia in hospitalized patients and its relationship with severity of illness and mortality
PLoS ONE, 2021 BackgroundLymphopenia is associated with various pathologies such as sepsis, burns, trauma, general anesthesia and major surgeries. All these pathologies are clinically expressed by the so-called Systemic Inflammatory Response Syndrome which does not ...
Carmen Cuellar +2 more
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Lymphopenia Caused by Virus Infections and the Mechanisms Beyond
Viruses, 2021 Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune responses and impact the clinical course of acute viral infections ...
Zhidong Zhang, Jing Guo, Meera Prajapati
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Possible Mechanisms of Lymphopenia in Severe Tuberculosis
Microorganisms, 2023 Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis). In lymphopenia, T cells are typically characterized by progressive loss and a decrease in their count results.
Fei Li, Yunjie Du, Dandan Chen
exaly +3 more sources
PLoS ONE, 2016 BackgroundThiopurines are known to cause lymphopenia (
Jonas Zeitz, Pascal Frei, Gerhard Rogler
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First-week absolute lymphocyte count dynamics and 28-day mortality in older adults with sepsis [PDF]
BMC Infectious DiseasesBackground Sepsis is a syndrome in which immune recovery is impaired and the clinical course becomes more severe, particularly in older patients. Although lymphopenia is an easily monitored indicator of sepsis-associated immune dysfunction, the clinical ...
Esra Yakışık Aktekin +4 more
doaj +2 more sources
PLoS ONE, 2020 The outbreak of SARS-CoV-2 began in December 2019 and rapidly became a pandemic. The present study investigated the significance of lymphopenia on disease severity.
Guangsen Zhang, Hongling Peng
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Lymphopenia in Esophageal Cancer: What Have We Learned?
Frontiers in Oncology, 2021 Lymphopenia caused by disease or treatment is frequent in patients with cancer, which seriously affects the prognosis of these patients. Immune checkpoint inhibitors (ICIs) have garnered attention as one of the most promising strategies for the treatment
Jia-Lin Wang +8 more
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Frontiers in Oncology, 2023 BackgroundSevere radiation-induced lymphopenia (RIL) in patients undergoing chemoradiotherapy (CRT) for non-small cell lung cancer (NSCLC) is associated with decreased immunotherapy efficacy and survival.
Peter S. N. van Rossum +9 more
doaj +1 more source