Results 31 to 40 of about 88,412 (297)

Immunodeficiency in DiGeorge Syndrome and Options for Treating Cases with Complete Athymia. [PDF]

, 2013
The commonest association of thymic stromal deficiency resulting in T-cell immunodeficiency is the DiGeorge syndrome (DGS). This results from abnormal development of the third and fourth pharyngeal arches and is most commonly associated with a ...
Davies, EG
core   +2 more sources

Potential Determinants for Radiation-Induced Lymphopenia in Patients With Breast Cancer Using Interpretable Machine Learning Approach

Frontiers in Immunology, 2022
Radiation-induced lymphopenia is known for its survival significance in patients with breast cancer treated with radiation therapy. This study aimed to evaluate the impact of radiotherapy on lymphocytes by applying machine learning strategies.
Hao Yu, Fang Chen, Fang Chen, Ka-On Lam, Ka-On Lam, Li Yang, Yang Wang, Jian-Yue Jin, Aya EI Helali, Feng-Ming (Spring) Kong, Feng-Ming (Spring) Kong   +10 more
doaj   +1 more source

Predictors of Oncologic Outcome in Patients Receiving Phase I Investigational Therapy for Recurrent or Metastatic Cervical Cancer [PDF]

Journal of Immunotherapy and Precision Oncology, 2023
Introduction: We aimed to identify clinical, pathologic, and treatment factors that are predictive of response and survival in patients with cervical cancer referred to phase I clinical trials. Methods: Patients with cervical cancer who received at least
Ji Son, Heather Y. Lin, Siqing Fu, Amadeo B. Biter, Ecaterina E. Dumbrava, Daniel D. Karp, Aung Naing, Shubham Pant, Sarina A. Piha-Paul, Jordi Rodon, Vivek Subbiah, Apostolia M. Tsimberidou, Timothy A. Yap, Michael M. Frumovitz, Amir A. Jazaeri, Pedro T. Ramirez, Shannon N. Westin, Ying Yuan, Funda Meric-Bernstam, David S. Hong   +19 more
doaj   +1 more source

Lymphopenia and mortality among patients undergoing coronary angiography: Long-term follow-up study

Cardiology Journal, 2022
BACKGROUND: Lymphopenia is associated with adverse prognosis in chronic disease states that are related to immune dysregulation. We aimed to determine the association between lymphopenia and mortality in patients presenting to coronary angiography and ...
Barak Zafrir, Sliman Hussein, Ronen Jaffe, Ofra Barnett-Griness, Walid Saliba   +4 more
doaj   +1 more source

Evaluation of berberine pellet effect on clinical recovery time in COVID-19 outpatients: A pilot clinical trial [PDF]

Avicenna Journal of Phytomedicine, 2023
Objective: Severe disease onset of COVID-19 may result in alveolar injury and respiratory failure. Apoptosis and inflammation are the main causes of respiratory distress syndrome.
Soodabeh Omidvar Tehrani, Mahboobeh Ghasemzadeh Rahbardar, Kamran Shoorgashti, Mohammad Javad Dehghan Nayeri, Amir Hooshang Mohammadpour, Hossein Hosseinzadeh   +5 more
doaj   +1 more source

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF [PDF]

, 2019
The ubiquitin-editing enzyme A20 is a well-known regulator of immune cell function and homeostasis. In addition, A20 protects cells from death in an ill-defined manner.
Boon, Louis, De Prijck, Sofie, Deswarte, Kim, Fayazpour, Farzaneh, Janssens, Sophie, Lambrecht, Bart, Martens, Arne, Takahashi, Nozomi, Tavernier, Simon, van Helden, Mary, van Loo, Geert, Van Moorleghem, Justine, Vandenabeele, Peter, Vanheerswynghels, Manon, Vergote, Karl, Vetters, Jessica, Vivier, Eric, Wahlen, Sigrid   +17 more
core   +6 more sources

Effectiveness of delayed-release dimethyl fumarate on patient-reported outcomes and clinical measures in patients with relapsing-remitting multiple sclerosis in a real-world clinical setting: PROTEC. [PDF]

, 2019
Ensaio clínico PROTEC, Protocolo nº 109MS408Abstract BACKGROUND: Patient-reported outcomes (PRO) and clinical outcomes give a broad assessment of relapsing-remitting multiple sclerosis (RRMS) disease.
Berger, T, Brambilla, L, Brochet, B, Giacomini, PS, Montalbán, X, Salgado, Salgado, AV, e outros   +5 more
core   +1 more source

Evaluation of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Covid-19 Patients Treated with Tocilizumab Due to Cytokine Storm

Genel Tıp Dergisi, 2023
Background/Aims: There is a significant increase in proinflammatory cytokine levels in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients entering cytokine storm.
Serkan Yavuz, Cengiz Burnik, Mehmet Mermer, Faysal Duksal   +3 more
doaj   +1 more source

Profound lymphopenia and bacteraemia

Internal Medicine Journal, 2006
AbstractBacteraemia often carries a poor prognosis despite prompt antibiotic therapy and is associated with late morbidity and mortality that is difficult to explain. Here, we describe perisistent B‐ and T‐ cell lymphopenia in a cohort of patients with Gram‐positive and Gram‐negative bacteraemia.
Hawkins, Carolyn, Collignon, Peter, Adams, D N, Bowden, Francis, Cook, Matthew   +4 more
openaire   +3 more sources

Gut microbiota composition as a candidate risk factor for dimethyl fumarate-induced lymphopenia in multiple sclerosis

Gut Microbes, 2022
Mounting evidence points towards a pivotal role of gut microbiota in multiple sclerosis (MS) pathophysiology. Yet, whether disease-modifying treatments alter microbiota composition and whether microbiota shape treatment response and side-effects remain ...
Martin Diebold, Marco Meola, Srinithi Purushothaman, Lena K Siewert, Elisabeth Pössnecker, Tim Roloff, Raija LP Lindberg, Jens Kuhle, Ludwig Kappos, Tobias Derfuss, Adrian Egli, Anne-Katrin Pröbstel   +11 more
doaj   +1 more source