Results 171 to 180 of about 4,419 (217)

Hyperleukocytosis, leukostasis and leukapheresis: Practice management

Blood Reviews, 2012
Hyperleukocytosis, arbitrarily defined in acute leukemia as a white blood cell count greater than 100,000/mL, often is associated with increased morbidity and mortality in patients with leukemic processes. It can induce leukostasis, tumor lysis syndrome and disseminated intravascular coagulopathy and has significant prognostic implications with or ...
Chezi Ganzel, Jacob M Rowe
exaly   +3 more sources

Leukostasis in adult acute hyperleukocytic leukemia: a clinician's digest [PDF]

Hematological Oncology, 2016
AbstractLeukostasis is a poorly understood and life‐threatening complication of acute hyperleukocytic leukemia. The incidence of hyperleukocytosis and leukostasis differs among various subtypes of leukemias. While the pathophysiology of leukostasis is not fully understood, recent research has elucidated many novel pathways that may have therapeutic ...
Aibek E Mirrakhimov
exaly   +3 more sources

Hyperleukocytosis and Leukostasis

2021
Patients with hematologic malignancies can develop a life-threatening hyperleukocytosis causing leukostasis, a hyperviscous state that results in decreased organ perfusion and potential complications such as disseminated intravascular coagulation, tumor lysis syndrome, and multiorgan failure. It may also be referred to as “blast crisis” as the elevated
Sharleen Yuan, Samantha J. Yarmis, Kami M. Hu   +2 more
openaire   +1 more source

Pulmonary leukostasis mimicking pulmonary embolism

Leukemia Research, 2000
We report a case of a 32-year-old woman who presented with shortness of breath and pleuritic chest pain, and mismatched perfusion defects on a ventilation-perfusion scan suspicious for pulmonary embolism. However, subsequent data revealed the diagnosis of acute myelogenous leukemia with hyperleukocytosis and associated pulmonary leukostasis ...
D A, Kaminsky, C G, Hurwitz, J I, Olmstead   +2 more
openaire   +2 more sources

Leukostasis: A phenomenon of prolymphocytic leukemia

American Journal of Hematology, 1989
AbstractWe are reporting a case of a patient with prolymphoctic leukemia complicated by fatal leukostasis. Multiple leukemic thrombi and leukoaggregales were demonstrated on postmortem examination in both the brain and lungs. This represents the first report pathologically documenting leukostasis in a chronic lymphoid malignancy.
A M, Megaludis, A, Winkelstein, Z R, Zeigler, T R, Miller   +3 more
openaire   +2 more sources

Pulmonary leukostasis: radiologic-pathologic study.

Radiology, 1987
The terminal chest radiographs of ten patients with pulmonary leukostasis were correlated with the autopsy findings. In six patients, no abnormalities attributable to leukostasis were seen on chest radiographs. In four patients, diffuse alveolar consolidations were caused by alveolar edema following leukostasis.
M A, van Buchem, J H, Wondergem, L J, Kool, J, te Velde, P M, Kluin, P J, Bode, D L, Busscher   +6 more
openaire   +2 more sources

Cerebrovascular nodules in a patient with leukostasis

Transfusion, 2002
A 68-year-old man was admitted to the hospital with an uncategorized, Philadelphia chromosome-negative myeloproliferative disorder associated with leukocytosis, anemia and thrombocytopenia. His WBC count on admission was 290,000 per mm 3 , and oral hydroxyurea was started on Day 2 in hospital, when the WBC count was 392,000 per mm 3 . On Day 3, the WBC
Xavier, Ortin, Joan, Cid, Andreu, Llorente, Tomas, Sempere, Arantxa, Ugarriza   +4 more
openaire   +2 more sources

RESPIRATORY FAILURE DUE TO LEUKOSTASIS IN LEUKAEMIA

Medical Journal of Australia, 1981
A case is presented in which leukostasis, which followed splenectomy for chronic granulocytic leukaemia in metamorphosis, was associated with respiratory failure. The pathophysiology and predisposing factors are discussed.
T, Frost, J P, Isbister, R B, Ravich
openaire   +2 more sources

Hyperleukocytosis and leukostasis: management of a medical emergency

Expert Review of Hematology, 2016
Hyperleukocytosis is defined as a white blood cell count greater than 100,000/mL in patients affected by acute leukemia and often it is associated with increased morbidity and mortality, that can be up to 40% if unrecognized. Areas covered: Risk factors include younger age, myelomonocytic or monocytic/monoblastic morphology, microgranular variant of ...
Giammarco, Sabrina, Chiusolo, Patrizia, Piccirillo, Nicola, Di Giovanni, Alessia, Metafuni, Elisabetta, Laurenti, Luca, Sica, Simona, Pagano, Livio   +7 more
openaire   +3 more sources

Endothelial Activation Antigens in Pulmonary Leukostasis in Leukemia

Acta Haematologica, 1993
Adhesion between leukemic cells and the vascular endothelium has been suggested to play a role in the development of leukostasis in myelocytic leukemia. To define the role of adhesion molecules on the surface of endothelial cells in leukostasis, we used immunohistochemistry to study the expression of endothelial leukocyte adhesion molecule-1 (ELAM-1 ...
M A, van Buchem, P C, Hogendoorn, J A, Bruijn, P M, Kluin   +3 more
openaire   +2 more sources