Results 1 to 10 of about 7,125 (253)

Leukapheresis and Hyperleukocytosis, Past and Future

International Journal of General Medicine, 2021
Dongdong Zhang,1 Yufan Zhu,2 Yanxia Jin,3 Natasha Mupeta Kaweme,3 Youhong Dong1 1Department of Oncology, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Xiangyang, Hubei, 441000, People’s Republic of China; 2Orthopedics department ...
Dongdong Zhang, Natasha Mupeta Kaweme, Youhong Dong   +2 more
exaly   +7 more sources

Hyperleukocytosis and Leukostasis in Acute Myeloid Leukemia: Can a Better Understanding of the Underlying Molecular Pathophysiology Lead to Novel Treatments?

Cells, 2020
Up to 18% of patients with acute myeloid leukemia (AML) present with a white blood cell (WBC) count of greater than 100,000/µL, a condition that is frequently referred to as hyperleukocytosis.
Jan Philipp Bewersdorf, Amer M Zeidan
exaly   +4 more sources

A young adult patient with Philadelphia positive acute lymphoblastic leukemia presenting with extreme hyperleukocytosis [PDF]

Clinical Case Reports
Key Clinical Message Extreme hyperleukocytosis (Leukocyte count >200 × 109/L) in an adolescent young adult (AYA) patient with B‐ALL could result in mild symptoms of leukostasis.
Gulten Tikit, Elif Yucesu, Aliye Serpil Sarıfakıoglu, Imdat Dilek, Sule Mine Bakanay   +4 more
doaj   +3 more sources

Hyperleukocytosis in Childhood Acute Leukemia: Early Complications and Survival Outcomes

Cancers, 2023
Simple Summary Hyperleukocytosis (WBC > 100 × 109/L) has been associated with unfavorable outcomes. Few studies have focused on childhood acute leukemia with hyperleukocytosis in developing countries, where the treatment outcomes remain poorer than in ...
Sirinthip Kittivisuit, Pornpun Sripornsawan, Natsaruth Songthawee   +2 more
exaly   +2 more sources

Comparison of early mortality between leukapheresis and non-leukapheresis in adult acute myeloid leukemia patients with hyperleukocytosis: a systematic review and meta-analysis

Hematology, 2022
Objectives One of the treatment modalities that can be used for hyperleukocytosis is leukapheresis. However, the result of studies showing the benefit of early mortality through the use of leukapheresis versus no leukapheresis is still inconclusive ...
Ikhwan Rinaldi, Noorwati Sutandyo, Kevin Winston   +2 more
doaj   +2 more sources

Transient hyperleukocytosis in one of the extreme preterm twins: A case report with review of literature

Indian Pediatrics Case Reports, 2023
Background: Although physiological leukocytosis is known in premature neonates, hyperleukocytosis (total leukocyte count more than 100 × 103 /μL) is rarely seen.
Mathews E Kuriakose, Shanu Chandran, Abdul Tawab   +2 more
doaj   +2 more sources

Leukapheresis in Pediatric Acute Leukemia with Hyperleukocytosis: A Single-Center Experience

Children, 2022
Hyperleukocytosis in pediatric acute leukemia is associated with increased morbidity and mortality and at present there is no consensus on the use of leukapheresis (LPH) for its management.
Sandra Renee Jones, April Rahrig, Amanda J. Saraf   +2 more
doaj   +2 more sources

Clinical characteristics and outcomes of children with newly diagnosed acute myeloid leukemia and hyperleukocytosis managed with different cytoreductive methods

Cancer, 2023
Hyperleukocytosis in patients with acute myeloid leukemia (AML) has been associated with worse outcomes. For cytoreduction, leukapheresis has been used but its clinical utility is unknown, and low‐dose cytarabine (LD‐cytarabine) is used as an alternative
Stanley B Pounds, Jesse Smith, Clifford M Takemoto   +2 more
exaly   +2 more sources

Case Report: Chronic myeloid leukemia in a 13-year-old—a rare pediatric case of extreme hyperleukocytosis in chronic phase [PDF]

Frontiers in Medicine
Pediatric Chronic Myeloid Leukemia (CML), a rare hematologic malignancy, accounts for only 2–3% of cases of leukemia in pediatric patients. The case presented here is of a previously healthy 13-year-old male, who came to the emergency department with ...
Mohammad Asees, Toleen Abdalhaq, Johnny Amer   +2 more
doaj   +2 more sources

Molecular profiling of patients with cytogenetically normal acute myeloid leukemia and hyperleukocytosis

Cancer, 2022
Acute myeloid leukemia (AML) with initial hyperleukocytosis is associated with high early mortality and a poor prognosis. The aims of this study were to delineate the underlying molecular landscape in the largest cytogenetic risk group, cytogenetically ...
Friederike Pastore, Alessandro Pastore, Stefan K Bohlander   +2 more
exaly   +2 more sources