Results 161 to 170 of about 123,231 (223)
Alveolar macrophages: development, respiratory homeostasis, signal pathways, diseases, and therapeutic opportunities: During embryonic development, fetal progenitors migrate to the developing lungs via a CX3CR1‐dependent mechanism to establish the TrAM pool.
Sihan Yang +4 more
wiley +1 more source
Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies
Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng +7 more
wiley +1 more source
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta +9 more
wiley +1 more source
ABSTRACT Introduction Allergic rhinitis (AR) and non‐allergic rhinitis (NAR) share overlapping symptoms but differ in pathophysiology and treatment. Current AR diagnosis relies on skin prick testing (SPT) and serum IgE quantification, both of which are complex.
Ke‐Zhang Zhu +4 more
wiley +1 more source
Plasma extracellular vesicles (EVs) from individuals with latent (LTB) or active tuberculosis (ATB) exhibit distinct proteomic compositions, reflecting the underlying immunometabolic states of each phase. In LTB, EVs are enriched in proteins associated with tissue remodeling and lipid metabolism, including TGFβ, APOA1, and APOE, which may participate ...
Eliud S.‐Peregrino +13 more
wiley +1 more source
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque +5 more
wiley +1 more source
Failed Mucosal Allostasis Distinguishes Murine IgG‐ From IgE‐Mediated Recurrent Severe Anaphylaxis
This study investigates IgE‐ and IgG‐mediated pathways in acute and recurrent anaphylaxis using a murine ASA‐PSA model, assessing barrier integrity, immune activation and tissue remodelling across pulmonary and intestinal compartments. Recurrent IgE‐ and IgG‐mediated anaphylaxis produces divergent mucosal outcomes despite comparable systemic severity ...
Abdurrahman Simsek +8 more
wiley +1 more source
Abstract The lungs have for a long time been recognised as having pharmacological significance as a specific organ to modulate the pharmacokinetics of endogenous substances needed to maintain homeostasis. The lungs are therefore the site of action of certain drugs that act on these homeostatic processes, resulting in systemic effects on the ...
Simon C. Pitchford
wiley +1 more source
Mast Cells in Host Defense Against Cutaneous Staphylococcus aureus Infection
Impact of S. aureus epicutaneous sensitization models on mast cell function in vivo. D. farinae and Staphylococcal enterotoxin B (SEB) activate Trpv1+ Tac1+ nociceptors to trigger the release of substance P (SP), which promotes mast cell degranulation through Mrgprb2. S.
Hannah Dychtenberg +3 more
wiley +1 more source
Daycare attendance, breastfeeding, and risk of asthma in the prospective MoBa and DIPP birth cohorts
The findings obtained in this study report inconsistent signals rather than systematic evidence that early daycare attendance modifies the effect of breastfeeding to protect against asthma. Abstract Background Daycare attendance and breastfeeding have been associated with asthma risk.
Susanna Tall +12 more
wiley +1 more source

