Results 71 to 80 of about 1,159,991 (294)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Method for a structured identification of suitable safety and securing systems for Level Crossings [PDF]

, 2009
Safety and securing systems for level crossing have a long life time. Once a system reaches a life time when it is no longer conform to applicable regulations, it has to be modernized or replaced.
Asbrock, Hartwig, Böhm, Thomas, Pelz, Markus   +2 more
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Evaluation Study of Level Crossings on Direct Crossing Routes (JPL) in Semarang City

Media Komunikasi Teknik Sipil
As a mass transportation system infrastructure, level crossings impact road users, including skidding, road damage, and accidents. Based on data from KAI DAOP 4 Semarang, there were 12 accidents at level crossings in 2023, while in 2024, the number ...
Anton Budiharjo, Fistirika Habibah, Frans Tohom   +2 more
doaj   +1 more source

Characteristic Feature of Self-Consistent Mean-Field in Level Crossing Region

, 2004
A shape change of the self-consistent mean-field induced by a configuration change is discussed within the conventional constrained Hartree-Fock (CHF) theory.
Audi, Bengtsson, Bengtsson, Bengtsson, Bengtsson, Berger, Berger, Berger, Dechargé, Dobaczewski, Dobaczewski, Dobaczewski, Dobaczewski, Egido, En-Guang Zhao, Flocard, Fumihiko Sakata, Girod, Gogny, Hackman, Hamamoto, Iwasawa, Laird, Langanke, Lu Guo, Molique, Nakatsukasa, Nazarewicz, Neergård, Patra, Petrovici, Satula, Tanaka, Tanaka, Toh, Toh, Woods   +36 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Level Crossing Analysis of Burgers Equation in 1+1 Dimensions

, 2006
We investigate the average frequency of positive slope $\nu_{\alpha}^{+}$, crossing the velocity field $u(x)- \bar u = \alpha$ in the Burgers equation.
A A Masoudi, A Bahraminasab, Bahraminasab A Sadegh Movahed M Nassiri S D Masoudi A A, Barabasi A-L, Gurbatov S N, H Rezazadeh, M Sadegh Movahed, Mathews J H, Newland D E, Rice S O, Rice S O, Risken H, Shahbazi F, Sreenivasan K R, Weinan E   +14 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Crossing statistics of laser light scattered through a nanofluid

, 2017
In this paper, we investigate the crossing statistics of speckle patterns formed in Fresnel diffraction region by a laser beam scattering through a nanofluid. We extend $zero-crossing$ statistics to assess dynamical properties of nanofluid.
Karimzadeh, R., Movahed, S. M. S., Pirlar, M. Arshadi, Razzaghi, D.   +3 more
core   +1 more source