Results 91 to 100 of about 271,704 (310)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Muon-Nitrogen Quadrupolar Level Crossing Resonance in a Charge Transfer Salt. [PDF]

J Phys Chem C Nanomater Interfaces, 2022
Berlie A, Pratt FL, Huddart BM, Lancaster T, Cottrell SP.   +4 more
europepmc   +1 more source

KAJIAN KEBUTUHAN PERLINTASAN TIDAK SEBIDANG JALUR KERETA API DENGAN JALAN RAYA DI TITIK PERLINTASAN GANEFO KECAMATAN MRANGGEN

Teknika, 2018
The crossing railway line with the highway is quite a lot in several places in Indonesia, especially on the island of Java. This is a problem in itself because it considers this crossing to have a negative impact on users of land transportation. Moreover,
Bambang Sudarmanto
doaj   +1 more source

Level crossing system for regional railway [PDF]

, 2011
Tato práce se zabývá návrhem koncepce přejezdového zabezpečovacího zařízení pro regionální dráhu. První část práce definuje základní pojmy a požadavky na přejezdové zabezpečovací zařízení vycházející z platných norem, směrnic a požadavků provozovatele ...
Červený, Jindřich
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Preventing railway suicides through level crossing removal: a multiple-arm pre-post study design in Victoria, Australia. [PDF]

Soc Psychiatry Psychiatr Epidemiol, 2022
Clapperton A, Dwyer J, Spittal MJ, Roberts L, Pirkis J.   +4 more
europepmc   +1 more source

Analysis of Failures of Automatic Level Crossing Devices

Engineering Proceedings
The safety of automatic level crossing devices (ALDs) is of utmost importance due to the need to ensure safe passage through railway crossings—accidents must not be allowed.
Emiliya Dimitrova, Vasil Dimitrov, Dragomira Dimitrova   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Modelling of Signal - Level Crossing System

Advances in Electrical and Electronic Engineering, 2006
The author presents an object-oriented model of a railway level-crossing system created for the purpose of functional requirements specification. Unified Modelling Language (UML), version 1.4, which enables specification, visualisation, construction and ...
Daniel Novak
doaj